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34 results about "Methylcarbamyl-PAF" patented technology
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Methylcarbamyl PAF C-8 is the C-8 analog of Methylcarbamyl PAF C-16.Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. 1,2 It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma. 1 In NRK-49 ...
Methylene carbamate linkers for use with targeted-drug conjugates
ActiveUS20160303254A1Pharmaceutical non-active ingredientsImmunological disordersCarbamateTargeting ligands
The present invention provides Lig-and-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.
Owner:SEAGEN INC
Acyloxymethylcarbamate prodrugs of oxazolidinones
The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria.
Owner:PHARMACIA & UPJOHN CO
Anti-mouse agent formula for cable insulation layers
InactiveCN104987663AProblems of preventing food damage from corroding wires and cablesInsulation layerMethylcyclopropane
The invention relates to an anti-mouse agent formula for cable insulation layers. The formula comprises, by mass, 30% of capsaicinoids or more, 30% of o-isopropylphenyl-n-methylcarbamate or alpha-cyano-3-phenoxy-benzyl-d-cis-2 or more, 30% of 2-dimethylcyclopropanecarboxylate or more, 1% of water or less and 5% of epoxy oil or more. Because irritant capsaicinoid extractives obtained from natural plants are adopted, the anti-mouse agent has the advantages of being nontoxic, environmentally friendly and free from traditional highly toxic pesticides, and the situation that PVC or PE wires and cables are seriously bitten or corroded by mice or termites when used in areas where mice or termites are rampant can be avoided.
Owner:FOSHAN YUEJIAXIN WIRE & CABLE
Method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate
InactiveUS20060122417A1High yieldHigh analytic purityCarbamic acid derivatives preparationOrganic compound preparationLeaving groupEthyl N-methylcarbamate
The compound of formula (III), optionally its alkaline salt, is reacted with a compound of formula VII, wherein X is a leaving group, resulting in (S)-rivastigmine of formula II, which is then optionally converted into (S)-rivastigmine hydrogentartrade of formula I.
![Method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate](https://images-eureka.patsnap.com/patent_img/5300f550-60cf-4b60-8972-67059df65250/US20060122417A1-20060608-C00001.png "Method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate")
![Method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate](https://images-eureka.patsnap.com/patent_img/5300f550-60cf-4b60-8972-67059df65250/US20060122417A1-20060608-C00002.png "Method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate")
![Method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate](https://images-eureka.patsnap.com/patent_img/5300f550-60cf-4b60-8972-67059df65250/US20060122417A1-20060608-C00003.png "Method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate")
Owner:ZENTIVA AS
Pesticide for preventing grape diseases and pests at young fruit stage and preparation method thereof
The invention discloses pesticide for preventing grape diseases and pests at the young fruit stage and a preparation method thereof. The pesticide is prepared from, by weight, fruits of cubeb litsea trees, n-hexane, concentrated sulfuric acid with the concentration being 95-98%, lemon grass oil, salicylic acid, validamycin, N,N-dimethyl carbamate, white carbon black micro powder, willow leaves, melia azedarach fruits, orange peel, ginger juice, betel nuts and a proper amount of water. At the young fruit stage of grapes, bacteroidal diseases are mainly prevented, the bactericidal performance of the pesticide is improved and can be effective for a long time, and the preventive effect can be achieved and is one main characteristic of the pesticide; meanwhile, plant type antibacterial materials are adopted for refining, biologically antibacterial substances are obtained, the using quantity of chemical poisonous substances is reduced, sedimentation of chemical toxicants is reduced, and planted grapes can be safe and hygienic.
Owner:六安市叶集区绿叶果木种植专业合作社
Immune detection method for residual aryl-N-methyl carbamate pesticide
InactiveCN101314618AImprove practicalityLarge analysis capacityImmunoglobulinsMaterial analysisBALB/cMethyl carbamate
The invention relates to a method for detecting the residual immunity of an aryl-N-methylcarbamates pesticide, and belongs to the biotechnology field. The method includes the steps as follows: a carrier protein is coupled with a general hapten (HA) of the aryl-N-methylcarbamates pesticide to obtain a complete antigen; by applying the hybridoma technique, the antigen immunized Balb / C mice are screened by adopting the ELISA method and subcloned by adopting the limiting dilution method to obtain the hybridoma cell strains capable of stably secreting the aryl-N-methylcarbamates pesticide; and monoclonal antibodies are prepared. Based on the monoclonal antibodies, four ELISA detection methods for detecting the residual immunity of the aryl-N-methylcarbamates pesticide are established. The method has high specificity, sensitivity and stability, and provides a quick, sensitive and specific technology for trace-detecting the aryl-N-methylcarbamates pesticides.
Owner:NANJING AGRICULTURAL UNIVERSITY
Cold-resistant flame-retardant rat-proof and termite-proof communication cable
InactiveCN105427953APrevent gnawingGuaranteed uptimeInsulated cablesCommunication cablesAntioxidantRare earth
The invention discloses a cold-resistant flame-retardant rat-proof and termite-proof communication cable. The cable comprises the following components by weight: 10-15 parts of silicone rubber, 15-20 parts of fluorinated silicone rubber, 10-15 parts of fluororubber, 3-7 parts of epoxy oil, 2-4 parts of a rare earth complex, 1-2 parts of lubricating oil, 5-15 parts of decabrominated dipheny ethane, 2-8 parts of antimonous oxide, 10-20 parts of traditional Chinese medicine extract, 2-5 parts of o-isopropylphenyl-n-methylcarbamate, 1-2 parts of paraffin, 0-5 parts of calcined clay and 1-3 parts of an antioxidant, wherein the traditional Chinese medicine extract is mixed extract of salvia japonica thunb., vervain, zanthoxylum bungeagum maxim and radix angelicae. The cable is good in cold resistance, high in tensile strength, easy to bend, convenient to construct and good in flame retardance; and the cable can be effectively prevented from being bitten by rodents, is good in rat-proof and termite-proof effects, is not cracked by frost under an outdoor low-temperature condition, ensures stable operation of communication lines, and avoids the phenomenon of an influence on operation of the communication lines caused by damage to the communication cable due to external environmental factors.
Owner:STATE GRID CORP OF CHINA +2
INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE)
ActiveUS20090068242A1Increase lethalityBiocideSilicon organic compoundsMethyl carbamateInsecticide-treated mosquito nets
The present invention includes insecticidal carbamates that are useful, for example, for the control of insects, such as mosquitoes, which can be used in applications where exposure to and / or contact with humans is likely. The insecticides of the present invention include phenyl N-methyl carbamates and compositions comprising them that exhibit species-selective inhibition of acetylcholinesterase (AChE) and are preferably toxic to mosquitoes but not humans. Of particular interest are compounds of Formula (I) and Formula (II):Compounds of Formula (I) and Formula (II) are especially suitable for insecticide treated nets and indoor residual spraying for mosquito control.
Owner:VIRGINIA TECH INTPROP INC
Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates
InactiveUS8420846B2High yieldReduce usageCarbamic acid derivatives preparationOrganic compound preparationMethyl carbamateRivastigmine
![Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates](https://images-eureka.patsnap.com/patent_img/b2a6d0b7-79a7-43d2-aac4-0d29d909ffd9/US08420846-20130416-C00001.png "Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates")
![Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates](https://images-eureka.patsnap.com/patent_img/b2a6d0b7-79a7-43d2-aac4-0d29d909ffd9/US08420846-20130416-C00002.png "Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates")
![Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates](https://images-eureka.patsnap.com/patent_img/b2a6d0b7-79a7-43d2-aac4-0d29d909ffd9/US08420846-20130416-C00003.png "Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates")
Owner:JUBILANT GENERICS
Anti-microbico elevator cable with automatic detection function
ActiveCN103065715AImprove anti-agingAvoid nibblingInsulated cablesInsulated conductorsFiberMethyl carbamate
The invention discloses an anti-microbico elevator cable with automatic detection function. The anti-microbico elevator cable with the automatic detection function comprises an outer sheath, a safety protective layer, an insulating layer and a combining cable core. The insulating layer, the safety protective layer and the outer sheath are coated outside the combining cable core in sequence. The outer sheath is composed of 98 percent of polrvinyl chloride and 2 percent of antibacterial agents. Sensing fibres are evenly arranged outside the insulating layer. The antibacterial agents is composed of the following materials of quality percentage: 32 percent of silver nitrate, 6.5 percent of cyclopropane carboxylic acid ester, 3.5 percent of zinc chloride, 30.5 percent of hydroxyl methoxy benzyl pelargonic acid and 27.5% percent of isopropyl phenyl methyl carbamate. According to the anti-microbico elevator cable with the automatic detection function, the structure of the cable is improved, thus service life of the cable is prolonged and damage to the cable of environment is reduced. Besides, the damaged location of the cable can be detected timely and accurately. The anti-microbico elevator cable with the automatic detection function is safe to use. Maintenance cost is reduced and human checking cost is reduced.
Owner:SICHER ELEVATOR
Compound insecticide containing fipronil and Etrofolan
InactiveCN100998330AImprove performanceExcellent performance and safetyBiocideAnimal repellantsFipronilLeafhopper
A composite insecticide instead of the high-poison organophosphorus insecticide for the rice borer, plant hopper, leafhopper, etc is composed of fipronil and isoprocarb in weight ratio of 1: (0.1-75).
Owner:江苏太湖地区农业科学研究所
Method for separating and measuring content of optical isomers in tartaric acid
PendingCN114062518AEasy to splitQuality improvementComponent separationAnalytical techniqueDimethyl carbamate
The invention relates to the technical field of chemical analysis, in particular to a method for separating and determining the content of optical isomers in tartaric acid. The invention provides a method for separating and determining the content of optical isomers in tartaric acid, which is carried out by using high performance liquid chromatography, and the analysis conditions are as follows: an amylose-tri [3, 5-dimethyl carbamate] derivative is used as a stationary phase; and L-tartaric acid and D-tartaric acid can be simply and quickly separated very well by taking n-hexane, isopropanol, tert-butyl alcohol and trifluoroacetic acid as mobile phases and performing isocratic elution, and the contents of the L-tartaric acid and the D-tartaric acid are measured.
Owner:WUHAN WUYAO PHARMA
High-voltage electrolyte adaptive to rapidly-chargeable lithium cobalt oxide battery and application of high-voltage electrolyte
ActiveCN113889667AInhibition of catalytic effectAvoid too thickSecondary cellsOrganic electrolytesElectrolytic agentMethyl carbamate
The invention discloses a high-voltage electrolyte adaptive to a rapidly-chargeable lithium cobalt oxide battery. The high-voltage electrolyte comprises a lithium salt, a non-aqueous organic solvent and an additive, and the additive comprises methyl 2-thienyl cyano carbon o dithioimino ester and methyl (difluorophosphoryl) methyl carbamate. The additive forms a layer of uniform and compact protective film with high ionic conductivity on the surface of the LiCoO2 material, so that dissolution of metal ions in a positive electrode material and collapse of the material structure are inhibited. A stable low-impedance SEI film in a partial inorganic form is formed on a negative electrode graphite interface, free migration and reduction of metal ions in the electrolyte can be inhibited, damage to the surface of the electrode is reduced; and through the synergistic effect of all the components in the electrolyte, the LiCoO2 positive electrode material and the graphite negative electrode lithium ion battery can have good cycle performance, fast charge performance and low-temperature performance under high voltage.
Owner:新乡华锐锂电新能源股份有限公司
Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate
Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate and salts thereof are disclosed. Methods of its use to treat diseases and disorders of the eye are also disclosed.
![Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate](https://images-eureka.patsnap.com/patent_img/04499071-dfa9-42e1-aa52-446414c741f2/US08735408-20140527-D00001.png "Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate")
![Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate](https://images-eureka.patsnap.com/patent_img/04499071-dfa9-42e1-aa52-446414c741f2/US08735408-20140527-D00002.png "Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate")
![Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate](https://images-eureka.patsnap.com/patent_img/04499071-dfa9-42e1-aa52-446414c741f2/US08735408-20140527-D00003.png "Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate")
Owner:LEXICON PHARM INC
Pesticide for phoenix tree
Owner:张媛媛
Method for detecting N-methyl carbamate pesticide residues
InactiveCN102749404BSensitive detectionDetection time savingComponent separationMethyl carbamatePesticide residue
Owner:TIANJIN SEA WATER DESALINATION & COMPLEX UTILIZATION INST STATE OCEANOGRAPHI
Pharmaceutical composition for diabetic nephropathy and its preparation and application
ActiveUS9161930B2Easy to usePrevent the rise of serum creatinineBiocideMetabolism disorderDiphenylmethaneNephrosis
The invention relates to application of 4,4′-diphenylmethane-bis(methyl) carbamates (DPMC) extracted and isolated from Cortex Mori and preparation of medicine for diabetic nephropathy. The pharmaceutical composition is made up of DPMC as active ingredient and the normal drug carriers, and the weight percentage of active ingredient is 0.1-99.5%. For the remarkable effect of prevention and cure for diabetic nephropathy and convenience for use, it will be a new facultative drug for patients.
Owner:GUANGZHOU CONSUN MEDICINE R & D CO LTD
Composition for controlling Macdunnoughia crassisigna Warren and application thereof
ActiveCN111466397ATrace high efficiencyStrong specificityBiocidePest attractantsMacaroeris nidicolensSexual Pheromones
The invention discloses a composition for controlling Macdunnoughia crassisigna Warren and application of the composition. The composition disclosed by the invention comprises a sex pheromone and a sex pheromone analogue of the Macdunnoughia crassisigna Warren, wherein the sex pheromone is cis-7-dodecenyl acetate, cis-9-tetradecenyl acetate and cis-11-hexadecen-1-ol; the sex pheromone analogue isone or more than one of cis-7-dodecenyl-N-methylcarbamate, cis-7-dodecenyl-N,N-dimethylcarbamate and cis-7-dodecenyl-N-methyl-N-ethylcarbamate; the mass ratio of the sex pheromone to the sex pheromoneanalogue is 1: (0.01-0.1). The composition provided by the invention can trap and kill male moths of Macdunnoughia crassisigna Warren more effectively, reduce the mating frequency and reduce the propagation rate, thereby achieving the purpose of efficiently controlling Macdunnoughia crassisigna Warren. The composition has the advantages of low consumption and environmental friendliness, can be accurately applied to insect condition prediction, mass trapping and mating interference, and has important meanings for comprehensive treatment of Macdunnoughia crassisigna Warren.
Owner:INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
Rat-bite-preventing special power pole tower formula
The invention relates to the technical field of power pole towers, and concretely discloses a rat-bite-preventing special power pole tower formula, which is prepared from the following raw materials in parts by weight: 100 parts of SG resin, 2 to 4 parts of tribasic lead sulfate, 35 to 45 parts of nanometer calcium carbonate, 0.5 to 1.5 parts of dibasic lead phosphite, 1 to 2 parts of DOP, 1 to 3parts of epoxidized soybean oil, 1 to 2 parts of metallic soap, 1.5 to 2 parts of triphenyl phosphite, 0.2 to 0.6 part of triazine-5UV-9, 0.3 to 0.8 part of polyethylene wax, 2 to 4 parts of ACR, 4 to6 parts of CPE, 3 to 5 parts of calcium carbonate, 0.7 to 1.5 parts of capsaicine, 2 to 6 parts of O-isopropylphenyl methyl carbamate and 1 to 2 parts of 2-dimethyl cyclopropane carboxylate. The formula provided by the invention overcomes the defects in the prior art; rat-repelling ingredients prepared from the capsaicine, the O-isopropylphenyl methyl carbamate and the 2-dimethyl cyclopropane carboxylate are added; nontoxicity and harmlessness are realized; the environment pollution cannot occur; for the best advantage, rat repelling effects can be achieved; the plastic power pole tower is prevented from being bit by rats.
Owner:HEFEI HAIYIN TOWER
Method for the preparation of pimavanserin base
Disclosed is a process for the synthesis of pimavanserin base with a high yield and purity, which comprises: a) converting tert-butyl-N-[(4-propan-2-yloxyphenyl)methyl]carbamate (Formula (I)) to 1-(isocyanatomethyl)-4-propan-2-yloxybenzene of formula (II) b) adding N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine (Formula (IV)) to the solution obtained in a) to give pimavanserin base, and c) purifying the pimavanserin base obtained in step b).
Owner:OLON
Double-solvent long-acting combined drug for killing parasites on body surfaces of livestock and poultry
InactiveCN109432077AAerosol deliveryPhosphorous compound active ingredientsDrugs solutionMethylcarbamic acid
The invention belongs to the technical field of design, research and development of veterinary drugs in the animal husbandry, and particularly discloses a double-solvent long-acting combined drug forkilling parasites on the body surfaces of livestock and poultry. The combined drug comprises the following components: 1.5%(w / v) of lambda-cyhalothrin, 6%(w / v) of 2-isopropoxybenzene-N-methylcarbamate, 0.2%(w / v) of phoxim, 84.8%(w / v) of food-grade white oil and the balance of a acetone substitute 15%(V / V); a preparation method thereof comprises the following steps: sequentially dissolving the lambda-cyhalothrin and the 2-isopropoxybenzene-N-methylcarbamate into the acetone substitute, and thoroughly stirring; adding the phoxim, and uniformly mixing; finally, with a mixture as a solute, dissolving again in the white oil; uniformly mixing the components in a mixer to obtain a combined drug solution with the concentration of 7.7%. The oil-type combined drug is insoluble in water, has very good adsorption performance, can form a difficultly removed drug film after being sprayed on the body surfaces of the livestock and poultry, slowly releases the drug effect, and can effectively kill theparasites on the body surfaces of the livestock and poultry.
Owner:VETERINARY INST XINJINAG ACADEMY OF ANIMAL SCI CLINIC MEDICAL SCI RES CENT XINJIANG ACADEMY OF ANIMAL HUSBANDRY SCI
Amino acid as well as preparation method and application thereof
ActiveCN114106034ARaw materials are cheap and easy to getShort stepsGroup 4/14 element organic compoundsOrganic compound preparationCarbamateOrganic synthesis
The invention provides amino acid as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: taking methyl cinnamate as a raw material, carrying out Sharpless asymmetric dihydroxylation on the methyl cinnamate and AD-mix-alpha to obtain a vicinal diol compound, esterifying paratoluensulfonyl chloride, introducing a tert-butyl dimethyl silyl ether protecting group, reacting with methyl-carbamate, and removing C-terminal methyl ester to dissociate carboxyl to obtain amino acid. Compared with the prior art, the method has the advantages that the raw materials are cheap and easy to obtain, the steps are short, and the overall yield is high; the used primary raw material methyl cinnamate is a commercial reagent easy to obtain and low in price; from methyl cinnamate, the N-methyl-3-hydroxyphenylalanine can be obtained by only five steps in the method disclosed by the invention, and the technical route is shorter; the total yield is close to 60% and is more than two times that of the prior art.
Owner:SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD +1
Compound insecticide containing fipronil and Etrofolan
InactiveCN100433979CImprove performanceExcellent performance and safetyBiocideAnimal repellantsLeafhopperFipronil
A composite insecticide instead of the high-poison organophosphorus insecticide for the rice borer, plant hopper, leafhopper, etc is composed of fipronil and isoprocarb in weight ratio of 1: (0.1-75).
Owner:江苏太湖地区农业科学研究所
Pesticide mixture capable of attracting insect pests and production method thereof
InactiveCN106614753AImprove insecticidal efficiencyBiocidePest attractantsAdditive ingredientMethylcarbamic acid
The invention discloses a pesticide mixture capable of attracting insect pests. Raw materials comprise the following components in parts by weight: 15-35 parts of dimethylcarbamate, 10-20 parts of amino oligosaccharin, 8-12 parts of pyrophosphate, 5-7 parts of fludioxonil, 10-20 parts of honey, 8-12 parts of sodium lignin sulfonate, 1-3 parts of hydroxymethyl cellulose, 4-6 parts of xanthan gum and 8-12 parts of tartaric acid. The pesticide mixture disclosed by the invention has the advantages that different insect pests can be killed by virtue of combination of multiple effective insecticidal ingredients, and the insect pests are attracted under the action of honey inside, so that the insecticidal efficiency is improved.
Owner:新昌县牛山农产品专业合作社
An antibacterial elevator cable with automatic detection
ActiveCN103065715BImprove anti-agingAvoid nibblingInsulated cablesInsulated conductorsFiberMethyl carbamate
The invention discloses an anti-microbico elevator cable with automatic detection function. The anti-microbico elevator cable with the automatic detection function comprises an outer sheath, a safety protective layer, an insulating layer and a combining cable core. The insulating layer, the safety protective layer and the outer sheath are coated outside the combining cable core in sequence. The outer sheath is composed of 98 percent of polrvinyl chloride and 2 percent of antibacterial agents. Sensing fibres are evenly arranged outside the insulating layer. The antibacterial agents is composed of the following materials of quality percentage: 32 percent of silver nitrate, 6.5 percent of cyclopropane carboxylic acid ester, 3.5 percent of zinc chloride, 30.5 percent of hydroxyl methoxy benzyl pelargonic acid and 27.5% percent of isopropyl phenyl methyl carbamate. According to the anti-microbico elevator cable with the automatic detection function, the structure of the cable is improved, thus service life of the cable is prolonged and damage to the cable of environment is reduced. Besides, the damaged location of the cable can be detected timely and accurately. The anti-microbico elevator cable with the automatic detection function is safe to use. Maintenance cost is reduced and human checking cost is reduced.
Owner:SICHER ELEVATOR
Synthesis method of dabigatran etexilate
InactiveCN114380797AThe synthetic route is simpleLow costOrganic chemistrySodium bicarbonateCarbamate
The invention relates to a synthetic method of dabigatran etexilate, which comprises the following steps: adding (Z)-hexyl (amino (4-aminophenyl) methylene) carbamate into a reaction flask filled with a solvent, dropwise adding a sodium hydroxide solution, heating for dissolving, separating liquid, and retaining an organic phase; adding sodium iodide, sodium bicarbonate, tetrabutylammonium bromide and 3-(1-(2-(chloromethyl)-1H-indole-5-yl) vinyl) (phenyl) amino) ethyl propionate into the organic phase, and performing liquid separation, cooling crystallization and centrifugation after the reaction is completed to obtain a dabigatran etexilate crude product; and refining the crude product of dabigatran etexilate to obtain a refined product of dabigatran etexilate. The synthesis route is simple, the cost is low, the amount of three wastes is small, the method is green and environment-friendly, the product purity is high, and the method is more suitable for large-scale industrial production; the molar yield of the obtained product is about 96%, the purity is about 99.8%, which is higher than 99.71% reported in the current literature, and the maximum single impurity is less than 0.1%, so that the requirements on next-step synthesis of the dabigatran etexilate mesylate are met.
Owner:山东诚汇双达药业有限公司
Synthesis method of AV-45 intermediate
ActiveCN111499570AReduce usageFew reaction stepsAmino preparation from aminesBulk chemical productionCarbamateTert butyl
The invention provides a synthesis method of an AV-45 intermediate. The synthesis method comprises the following steps: (1) carrying out an HECK reaction on tert-butyl-N-methyl-4-vinylphenyl carbamateand 2-bromo-5-iodopyridine to obtain an intermediate A; and (2) condensing the intermediate A and triethylene glycol to obtain a target compound, namely the AV-45 intermediate. According to the invention, a conventional synthesis method of (E)-tert-butyl-4-(2-(6-(2-(2-(2-hydroxyethyl)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate is improved; few reaction steps are included, and the useof reagents with pungent smell is avoided; and of the intermediate and the target compound prepared through the method can be direct purified through recrystallization, operation is simple, and yieldis high.
Owner:INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE)
ActiveUS8129428B2Increase lethalityBiocideSilicon organic compoundsMethyl carbamateInsecticide-treated mosquito nets
Owner:VIRGINIA TECH INTPROP INC
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