33 results about "Methylcarbamyl-PAF" patented technology

The present invention provides Lig-and-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.

The invention relates to an anti-mouse agent formula for cable insulation layers. The formula comprises, by mass, 30% of capsaicinoids or more, 30% of o-isopropylphenyl-n-methylcarbamate or alpha-cyano-3-phenoxy-benzyl-d-cis-2 or more, 30% of 2-dimethylcyclopropanecarboxylate or more, 1% of water or less and 5% of epoxy oil or more. Because irritant capsaicinoid extractives obtained from natural plants are adopted, the anti-mouse agent has the advantages of being nontoxic, environmentally friendly and free from traditional highly toxic pesticides, and the situation that PVC or PE wires and cables are seriously bitten or corroded by mice or termites when used in areas where mice or termites are rampant can be avoided.

The compound of formula (III), optionally its alkaline salt, is reacted with a compound of formula VII, wherein X is a leaving group, resulting in (S)-rivastigmine of formula II, which is then optionally converted into (S)-rivastigmine hydrogentartrade of formula I.

The invention discloses a cold-resistant flame-retardant rat-proof and termite-proof communication cable. The cable comprises the following components by weight: 10-15 parts of silicone rubber, 15-20 parts of fluorinated silicone rubber, 10-15 parts of fluororubber, 3-7 parts of epoxy oil, 2-4 parts of a rare earth complex, 1-2 parts of lubricating oil, 5-15 parts of decabrominated dipheny ethane, 2-8 parts of antimonous oxide, 10-20 parts of traditional Chinese medicine extract, 2-5 parts of o-isopropylphenyl-n-methylcarbamate, 1-2 parts of paraffin, 0-5 parts of calcined clay and 1-3 parts of an antioxidant, wherein the traditional Chinese medicine extract is mixed extract of salvia japonica thunb., vervain, zanthoxylum bungeagum maxim and radix angelicae. The cable is good in cold resistance, high in tensile strength, easy to bend, convenient to construct and good in flame retardance; and the cable can be effectively prevented from being bitten by rodents, is good in rat-proof and termite-proof effects, is not cracked by frost under an outdoor low-temperature condition, ensures stable operation of communication lines, and avoids the phenomenon of an influence on operation of the communication lines caused by damage to the communication cable due to external environmental factors.

The invention discloses an anti-microbico elevator cable with automatic detection function. The anti-microbico elevator cable with the automatic detection function comprises an outer sheath, a safety protective layer, an insulating layer and a combining cable core. The insulating layer, the safety protective layer and the outer sheath are coated outside the combining cable core in sequence. The outer sheath is composed of 98 percent of polrvinyl chloride and 2 percent of antibacterial agents. Sensing fibres are evenly arranged outside the insulating layer. The antibacterial agents is composed of the following materials of quality percentage: 32 percent of silver nitrate, 6.5 percent of cyclopropane carboxylic acid ester, 3.5 percent of zinc chloride, 30.5 percent of hydroxyl methoxy benzyl pelargonic acid and 27.5% percent of isopropyl phenyl methyl carbamate. According to the anti-microbico elevator cable with the automatic detection function, the structure of the cable is improved, thus service life of the cable is prolonged and damage to the cable of environment is reduced. Besides, the damaged location of the cable can be detected timely and accurately. The anti-microbico elevator cable with the automatic detection function is safe to use. Maintenance cost is reduced and human checking cost is reduced.

The invention relates to the technical field of chemical analysis, in particular to a method for separating and determining the content of optical isomers in tartaric acid. The invention provides a method for separating and determining the content of optical isomers in tartaric acid, which is carried out by using high performance liquid chromatography, and the analysis conditions are as follows: an amylose-tri [3, 5-dimethyl carbamate] derivative is used as a stationary phase; and L-tartaric acid and D-tartaric acid can be simply and quickly separated very well by taking n-hexane, isopropanol, tert-butyl alcohol and trifluoroacetic acid as mobile phases and performing isocratic elution, and the contents of the L-tartaric acid and the D-tartaric acid are measured.

The invention discloses a high-voltage electrolyte adaptive to a rapidly-chargeable lithium cobalt oxide battery. The high-voltage electrolyte comprises a lithium salt, a non-aqueous organic solvent and an additive, and the additive comprises methyl 2-thienyl cyano carbon o dithioimino ester and methyl (difluorophosphoryl) methyl carbamate. The additive forms a layer of uniform and compact protective film with high ionic conductivity on the surface of the LiCoO2 material, so that dissolution of metal ions in a positive electrode material and collapse of the material structure are inhibited. A stable low-impedance SEI film in a partial inorganic form is formed on a negative electrode graphite interface, free migration and reduction of metal ions in the electrolyte can be inhibited, damage to the surface of the electrode is reduced; and through the synergistic effect of all the components in the electrolyte, the LiCoO2 positive electrode material and the graphite negative electrode lithium ion battery can have good cycle performance, fast charge performance and low-temperature performance under high voltage.

The invention discloses a method for detecting N-methyl carbamate pesticide residues. The method includes treating a water sample by means of extracting solid in advance; preparing a series of mixed methanol standard solutions of the N-methyl carbamate pesticide residues; analyzing the standard solutions by an ultra-fast chromatographic ultraviolet detector, and drawing a standard curve by using mass concentrations of the standard solutions as horizontal coordinates and peak areas of the standard solutions as vertical coordinates to obtain a standard curvilinear regression equation; and analyzing the water sample to be analyzed by the ultra-fast chromatographic ultraviolet detector and respectively computing mass concentrations of the N-methyl carbamate pesticide residues in the water sample to be analyzed according to the peak areas. By the aid of the method, a gap in the technology for detecting the N-methyl carbamate pesticide residues in environmental water is filled, mass concentrations of trace metolcarb, isoprocarb, diethofencarb and fenobucarb can be obtained simultaneously by one-step detection, and the method has the advantages of simplicity, capability of saving time, sensitivity and high efficiency. In addition, the ultra-fast liquid chromatographic ultraviolet detection method is universal and is popularized and applied easily.

The invention discloses a composition for controlling Macdunnoughia crassisigna Warren and application of the composition. The composition disclosed by the invention comprises a sex pheromone and a sex pheromone analogue of the Macdunnoughia crassisigna Warren, wherein the sex pheromone is cis-7-dodecenyl acetate, cis-9-tetradecenyl acetate and cis-11-hexadecen-1-ol; the sex pheromone analogue isone or more than one of cis-7-dodecenyl-N-methylcarbamate, cis-7-dodecenyl-N,N-dimethylcarbamate and cis-7-dodecenyl-N-methyl-N-ethylcarbamate; the mass ratio of the sex pheromone to the sex pheromoneanalogue is 1: (0.01-0.1). The composition provided by the invention can trap and kill male moths of Macdunnoughia crassisigna Warren more effectively, reduce the mating frequency and reduce the propagation rate, thereby achieving the purpose of efficiently controlling Macdunnoughia crassisigna Warren. The composition has the advantages of low consumption and environmental friendliness, can be accurately applied to insect condition prediction, mass trapping and mating interference, and has important meanings for comprehensive treatment of Macdunnoughia crassisigna Warren.

The invention relates to the technical field of power pole towers, and concretely discloses a rat-bite-preventing special power pole tower formula, which is prepared from the following raw materials in parts by weight: 100 parts of SG resin, 2 to 4 parts of tribasic lead sulfate, 35 to 45 parts of nanometer calcium carbonate, 0.5 to 1.5 parts of dibasic lead phosphite, 1 to 2 parts of DOP, 1 to 3parts of epoxidized soybean oil, 1 to 2 parts of metallic soap, 1.5 to 2 parts of triphenyl phosphite, 0.2 to 0.6 part of triazine-5UV-9, 0.3 to 0.8 part of polyethylene wax, 2 to 4 parts of ACR, 4 to6 parts of CPE, 3 to 5 parts of calcium carbonate, 0.7 to 1.5 parts of capsaicine, 2 to 6 parts of O-isopropylphenyl methyl carbamate and 1 to 2 parts of 2-dimethyl cyclopropane carboxylate. The formula provided by the invention overcomes the defects in the prior art; rat-repelling ingredients prepared from the capsaicine, the O-isopropylphenyl methyl carbamate and the 2-dimethyl cyclopropane carboxylate are added; nontoxicity and harmlessness are realized; the environment pollution cannot occur; for the best advantage, rat repelling effects can be achieved; the plastic power pole tower is prevented from being bit by rats.

The invention provides amino acid as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: taking methyl cinnamate as a raw material, carrying out Sharpless asymmetric dihydroxylation on the methyl cinnamate and AD-mix-alpha to obtain a vicinal diol compound, esterifying paratoluensulfonyl chloride, introducing a tert-butyl dimethyl silyl ether protecting group, reacting with methyl-carbamate, and removing C-terminal methyl ester to dissociate carboxyl to obtain amino acid. Compared with the prior art, the method has the advantages that the raw materials are cheap and easy to obtain, the steps are short, and the overall yield is high; the used primary raw material methyl cinnamate is a commercial reagent easy to obtain and low in price; from methyl cinnamate, the N-methyl-3-hydroxyphenylalanine can be obtained by only five steps in the method disclosed by the invention, and the technical route is shorter; the total yield is close to 60% and is more than two times that of the prior art.

The invention discloses a pesticide mixture capable of attracting insect pests. Raw materials comprise the following components in parts by weight: 15-35 parts of dimethylcarbamate, 10-20 parts of amino oligosaccharin, 8-12 parts of pyrophosphate, 5-7 parts of fludioxonil, 10-20 parts of honey, 8-12 parts of sodium lignin sulfonate, 1-3 parts of hydroxymethyl cellulose, 4-6 parts of xanthan gum and 8-12 parts of tartaric acid. The pesticide mixture disclosed by the invention has the advantages that different insect pests can be killed by virtue of combination of multiple effective insecticidal ingredients, and the insect pests are attracted under the action of honey inside, so that the insecticidal efficiency is improved.

The present invention relates to a method for purifying (1S)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL by distilling a reaction mixture which comprises between 25 and 99% by weight of (IS)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL.

The invention provides a synthesis method of an AV-45 intermediate. The synthesis method comprises the following steps: (1) carrying out an HECK reaction on tert-butyl-N-methyl-4-vinylphenyl carbamateand 2-bromo-5-iodopyridine to obtain an intermediate A; and (2) condensing the intermediate A and triethylene glycol to obtain a target compound, namely the AV-45 intermediate. According to the invention, a conventional synthesis method of (E)-tert-butyl-4-(2-(6-(2-(2-(2-hydroxyethyl)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate is improved; few reaction steps are included, and the useof reagents with pungent smell is avoided; and of the intermediate and the target compound prepared through the method can be direct purified through recrystallization, operation is simple, and yieldis high.