The invention discloses a TPU sheath material for charging cables as well as preparation and application of the TPU sheath material. According to the technical scheme, thermoplastic polyurethane (TPU)is adopted as a matrix, a modifier, a compatilizer, a halogen-free flame retardant, a flame retardant synergist, a lubricant, an antioxidant and a rat-proof agent are added, all the components are matched with one another to achieve a synergistic effect, so that the cable sheath material can ensure the original good processability and elasticity of thermoplastic polyurethane (TPU) and has good mechanical properties, heat resistance, low temperature resistance, wear resistance, chemical liquid resistance, water resistance and flame retardancy, the cracking resistance of the TPU sheath materialis also significantly improved, and the material is effectively prevented from being bitten by rats and has an excellent surface matte effect.