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121 results about "Carbamate esters" patented technology

Substituted piperidine carbamates

Novel substituted piperidine carbamates, pharmaceutical compositions comprising them and use thereof in the treatment and / or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and / or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.
Owner:NOVO NORDISK AS

Film-forming material, crosslinkers and coating compositions containing silane, methods for producing a coating composition and a coated substrate

Film-forming materials include resins and / or crosslinkers having a -Si(OR)3 group. Film-forming resins can include epoxy, acrylic, polyurethane, polycarbonate, polysiloxane, polyvinyl, polyether, aminoplast, and polyester resins. A process to produce a film-forming resin includes reacting various polymers to incorporate a pendent group comprising a -Si(OR)3 group. Crosslinkers for polymerizing a film-forming material include at least two functional groups reactive with a film-forming material and at least one pendent group comprising a -Si(OR)3 group. Functional groups reactive with a film-forming material include isocyanate, blocked isocyanate, uretdione, epoxide, hydroxyl, carboxyl, ester, ether, carbamate, aminoalkanol, aminoalkylether, amide, or amine groups. Film-forming resins and / or crosslinkers having a -Si(OR)3 group can be used in methods of producing coating compositions. Coating compositions can be used to coat a substrate, such as a metal substrate, by electrodeposition. Applied coatings containing the film-forming resins can be cured to form crosslinked films on substrates.
Owner:BASF COATINGS GMBH

Lubricant additive with antioxidant, antiwear and rustproof functions as well as preparation method and application thereof

The invention provides a lubricant additive with antioxidant, antiwear and rustproof functions. The lubricant additive with the antioxidant, antiwear and rustproof functions is mainly prepared from the following raw material components in parts by mass: 10-60 parts of alkylbenzene sulfonate, 30-60 parts of alkyl diphenylamine, 20-40 parts of isopropyl beta-(3,5-ditertbutyl-4-hydroxy phenyl) propionate, 10-30 parts of methylene-bis-alkyl dithiocarbamate, 10-30 parts of a sulfur-phosphorus-nitrogen type extreme pressure agent and 5-20 parts of a sulfurized calcium phenate type high temperature clearing agent. A preparation method of the lubricant additive with the antioxidant, antiwear and rustproof functions comprises the following steps: mixing all the raw materials and uniformly stirring, so that the lubricant additive with the antioxidant, antiwear and rustproof functions is obtained. The lubricant additive of the embodiment of the invention is well applied to engine lubricant, hydraulic oil, gear lubricant, steam turbine lubricant and compressor lubricant, is respectively excellent in the antioxidant, antiwear and rustproof aspects and also has excellent clearing function, functionality of the lubricant additive can not be reduced no matter at high temperature or low temperature, and some properties or a certain property of lubricant can be obviously improved.
Owner:锦州康泰润滑油添加剂有限公司

Substitued piperazine carbamates

Novel piperazines, pharmaceutical compositions comprising them and use thereof in the treatment and / or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and / or prevention of diseases and disorders in which modulation of lipolysis, such as decreased lipolysis is beneficial.
Owner:NOVO NORDISK AS

Beta-carboline-cycloenone derivative based on dual response to pH value and GSH and application thereof

The invention discloses a beta-carboline-cycloenone derivative with a structure as shown in a general formula which is described in the specification. According to the invention, an electron-donatinggroup is introduced into a proper part of beta-carboline, and the 3-site amino group of beta-carboline is connected with cycloenone having anti-tumor activity by utilizing a carbamate bond, so the novel beta-carboline-cycloenone derivative is designed and synthesized. The derivative realizes pH and GSH dual-response fluorescence imaging and diagnosis in a tumor microenvironment, and can selectively target to GSTpi highly-expressed in tumor tissue, so tumor cell proliferation can be significantly inhibited. Such a pH / GSH dual-response fluorescence and cancer-targeting treatment diagnosis and treatment drug provides a new choice for accurate diagnosis and targeting treatment of tumors, and broadens the application of multifunctional molecules in accurate medical treatment.
Owner:NANTONG UNIVERSITY

Anti-wear, anti-friction and anti-oxidant additive and energy-saving hydraulic oil containing same

InactiveCN108559583AGood anti-wear performanceExtend mechanical lifeAdditivesParaffin waxSpecific gravity
The invention discloses an anti-wear, anti-friction and anti-oxidant additive and energy-saving hydraulic oil containing the same. Zinc dialkyl thiosulfate, molybdenum phosphate, molybdenum dithiocarbamate, a boron nitrogen compound, borate, organic molybdenum, methylene bisdibutyl dithiocarbamate, polyisobutylene dibutyl diimide, 350N paraffin base oil, polyalphaolefin PAO8 and polyol ester are used as raw materials, and the specific gravity of each component is strictly controlled; the borate has good anti-wear performance, so that the service life of a machine can be prolonged by more thanone time, the bearing capacity is strong, and a sintering accident can be prevented; the friction coefficient is low, and the friction coefficient of oil prepared from a borate agent can be as low as0.05-0.06 at a room temperature; most of the conventional lubricating oil uses an oil-soluble liquid anti-wear agent, and solid anti-wear agents such as graphite, molybdenum disulfide and polytetrafluoroethylene can be applied only when particles thereof are small and stably dispersed in base oil of the lubricating oil; the anti-wear, anti-friction and anti-oxidant additive has very good anti-wearand friction-reducing effects.
Owner:SHANDONG YUANGEN CHEM TECH RES & DEV CO LTD

Polycationic gene carriers formed of endogenous amino group-bearing monomers

The present invention is directed to a design of and a method to synthesize polycations for gene (DNA and RNA) delivery. According to this design, the polycations (also said cationic polymers) are formed by polymerization of endogenous monomers bearing sufficient amino groups through degradable bonds with linker molecules or with themselves. The amino group-bearing monomers are those naturally existing in or nontoxic to human body. The linker molecules are those which are not only degradable to nontoxic fragments but also able to release the amino group-bearing monomers in their native state upon degradation. Some examples for the endogenous amino group-bearing monomers are spermine, spermidine, serine or N,N-dimethyl serine, and histidine. Examples for the degradable chemical bonds formed between the amino group-bearing monomers are carbamate, imine, amide, carbonate, and ester. In order to improve degradability or proton sponging effect, low pKa (<8) amino group(s) or other electron donating group(s) is incorporated in the linker between the two (or three) reactive groups for linking the amino group-bearing monomers. These polycationic carrier systems can be used for nano-encapsulation and transfection of gene materials.
Owner:BIOPHARM SOLUTIONS

Carbamates as HIV anti-viral agents

The present invention relates to carbamate derivatives having RNase H, polymerase and / or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.
Owner:WYETH

Preparation method of high-strength and high-toughness vinyl ester resin

The invention relates to a preparation method of high-strength and high-toughness vinyl ester resin. The preparation method comprises the following steps: firstly, reacting diisocyanate with polyether glycol to prepare an isocyanate-terminated polyurethane prepolymer (PUR), then reacting the polyurethane prepolymer (PUR) with hydroxyl of epoxy resin to obtain polyurethane block modified epoxy resin (UE), and finally, reacting with unsaturated monocarboxylic acid to obtain the polyurethane modified vinyl ester resin (VER). According to the preparation method disclosed by the invention, not only is a flexible polyether chain segment blocked into a resin structure, but also the functionality of the vinyl ester resin is increased due to the existence of a carbamate bond. Therefore, the high-strength and high-toughness vinyl ester resin is low in shrinkage rate and high in strength after being cured, the impact resistance is obviously improved, the comprehensive performance is good, the product is stable, and the reaction route is reasonable.
Owner:湖北海星瑞新材料科技有限公司

Rapid detection method special for pesticide residues of dichlorvos in fresh fruits and vegetables

The invention discloses a rapid detection method special for pesticide residues of dichlorvos in fresh fruits and vegetables, and belongs to the technical field of rapid detection of pesticide residues. Based on the specific inhibition effect of organophosphorus pesticides and carbamate pesticides on the activity of acetylcholin esterase (AChE, derived from duck blood extraction), the inhibition degree of AChE is detected by using an ultrahigh-sensitivity fluorescein fluorescent probe. When the addition amount of the dichlorvos in the detection system is the same, the weakened fluorescence intensity (I dichlorvos) of the dichlorvos is 100 times or more lower than that of other pesticides (I other pesticides), thereby showing that even if the content of the dichlorvos is 100 times lower than that of other pesticides, the residual quantity of the dichlorvos can be quantitatively detected. Through diluting a pesticide residue extraction liquid by 100 times, the influence of other pesticide residues on AChE is reduced, the pesticide residue range of specific detection of dichlorvos in fruits and vegetables is 0.02-1.2 mg / kg, the error rate R2 of a detection standard curve is greater than 0.99, and the standard addition recovery rate of the fresh fruits and vegetables reaches 71-86%.
Owner:DALIAN UNIV OF TECH

Process method for separating talc and chalcopyrite through three-step method and collecting agent used in process method

The invention provides a process method for separating talc and chalcopyrite through a three-step method and a collecting agent used in the process method. The method comprises the steps of carrying out ore grinding, carrying out first-step roughing, carrying out second-step concentration, and carrying out third-step table reselection and regrinding operation. The process method aims at separationof the talc and the chalcopyrite, the preferential copper separation technological process is adopted for the first time under the condition that a special-effect talc inhibitor is not added, and effective separation of the talc and the chalcopyrite is achieved. According to the process method, the collecting agent TB-1 formed by mixing isobutyl xanthate propionitrile ester, N-allyl-O-alkyl thiocarbamate and Spans type sorbitan ester is adopted to strengthen flotation of the chalcopyrite, the thickness of a foam layer is adjusted through the defoaming performance of the collecting agent TB-1,and the relative floating speed of the talc and the chalcopyrite is changed; and the flotation and reselection combined technological process is adopted, and effective separation of talc and chalcopyrite is achieved through three steps. The flotation reagent adopted in the process method has the characteristics of low toxicity or no toxicity, environment friendliness, good effect and the like, and an environment-friendly and high-efficiency process method for separating the talc and the chalcopyrite is provided.
Owner:安徽铜冠产业技术研究院有限责任公司
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