81 results about "Carbamate esters" patented technology

The invention discloses a preparation method of a starch-polyvinyl alcohol-based room temperature curing wood adhesive for plywood, and belongs to the technical field of wood adhesives. At present, wood adhesives mainly come from petrochemical resources and mostly need hot-pressing curing, the invention provides the preparation method of the wood adhesive with starch and polyvinyl alcohol as main materials, and heat-free bonding can be achieved. The preparation method comprises the following steps: firstly, reacting corn starch with isocyanate to obtain carbamic acid esterified starch, then adding a polyvinyl alcohol aqueous solution, uniformly stirring to obtain a starch-polyvinyl alcohol-based room-temperature curing wood adhesive, uniformly coating a wood veneer with the starch-polyvinyl alcohol-based room-temperature curing wood adhesive, forming an odd-layer plate blank according to the principle that the fiber directions of adjacent layers are vertical, and then carrying out cold press molding to obtain the wood veneer. The starch-polyvinyl alcohol-based room temperature curing plywood can be obtained. The prepared starch-polyvinyl alcohol-based room temperature curing plywood has the advantages of being easy to prepare, high in bonding strength, good in water resistance, free of formaldehyde, free of hot pressing and the like, and has a good market popularization prospect.

The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for in vivo therapeutic applications. The lipids of the present invention are characterized as particularly hydrolytically and alcoholytically stable, while maintaining their biological activity.

The invention relates to the field of coatings, in particular to a solvent-free epoxy coating for a drinking water tank and a preparation method thereof.The solvent-free epoxy coating is prepared from a component A and a component B. The component A comprises 40-60 parts of epoxy resin, 5-20 parts of reactive diluent, 0.3-0.5 part of dispersing agent, 0.1-0.8 part of defoaming agent, 0.6-1.2 parts of thixotropic agent, 20-35 parts of pigment and 10-20 parts of filler; the epoxy resin comprises bisphenol A epoxy vinyl ester resin and hydrogenated bisphenol A resin; the active diluent comprises a cardanol-based active diluent and 4-epoxy isoeugenol; the dispersing agent comprises a polymeric dispersing agent and polyurethane acrylate porous microspheres; the component B comprises a modified alicyclic amine curing agent and cardanol carbamate, and the mass ratio of the modified alicyclic amine curing agent to the cardanol carbamate is (1.8-5): 1; the amine value of the modified alicyclic amine curing agent is 360 to 420 mgKOH / g. The solvent-free epoxy coating for the drinking water tank is non-toxic, has relatively strong adhesive force, water resistance, flexibility and antibacterial property and relatively long service life, and is suitable for various drinking water tanks.

The invention discloses a dithiocarbamate monomer, a holographic recording medium, a preparation method and a related device, the structural general formula of the monomer is as shown in G1 and G2, R1 represents any one of hydrogen, halogen and C1-C4 alkyl, R3 represents any one of hydrogen, halogen and C1-C4 alkyl, A1 represents C1-C4 alkyl, A2 represents hydrogen or methyl, n is a positive integer, and n = 1-10. The dithiocarbamate monomer provided by the invention has high refractive index, and the holographic recording medium with high sensitivity, high diffraction efficiency and high refractive index modulation degree can be obtained by applying the dithiocarbamate monomer to preparation of the photopolymer holographic recording medium; holographic recording media can be used to prepare volume holographic gratings, holographic optical elements, and optical devices.

The invention provides a synthetic method and application of pure water-based acrylic resin. The preparation method comprises the following steps: firstly, esterifying acrylic acid and fatty alcohol to prepare an acrylate monomer with a flexible chain segment and hydrophilic-hydrophobic balance; then, acrylic ester and diethanol amine are subjected to aminolysis to generate a hydroxyl-containing acrylamide derivative, hydroxyl and trimethylolpropane ester exchange is carried out to form a branched node, and the crosslinking potential of a molecular chain is increased; the hydroxyl group and the isocyanate group are combined to generate a carbamate hard segment and construct a hyperbranched skeleton, and meanwhile, double bonds are reserved for subsequent free radical polymerization; and finally, copolymerizing the flexible monomer, the hyperbranched hard-segment monomer and hydroxyethyl acrylate to form the composite resin containing high-density hydroxyl groups, wherein the soft and hard segments of the composite resin are microphase-separated. The pure water-based acrylic resin prepared by the invention has excellent adhesive force, weather resistance, solvent resistance and the like, is applied to baking varnish, effectively improves the performance of the baking varnish, and has the characteristics of being green and environment-friendly.

This invention relates to carbamate compounds of Formula (I), as further detailed herein, which are used for inhibition of SARM1 proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

The invention discloses a carbamate compound, lipid nanoparticles constructed by the carbamate compound, a pharmaceutical composition and application of the carbamate compound. A lipid nanoparticle carrier constructed by the series of cationic amino lipid compounds (formula I) can deliver mRNA to the spleen in a targeted manner on the premise of ensuring high efficiency and low toxicity, so that the immune response is effectively stimulated, the curative effect is remarkably improved, and the cationic amino lipid compound has important clinical application significance in cancer treatment.

The invention discloses a fluorescent nanosensor based on the Strecker-like method for synthesizing isoindole and combining cadmium telluride quantum dots and its application, which is a composite system composed of 2,3-naphthalene dicarboxaldehyde and potassium sulfite as probe solutions and combined with cadmium telluride quantum dots. Cadmium telluride quantum dots are used as a fluorescence source to emit bright red fluorescence, 2,3-naphthalene dicarboxaldehyde and potassium sulfite are open-type probe solutions, and the addition of carbamate pesticides interacts with 2,3-naphthalene dicarboxaldehyde and potassium sulfite to synthesize an isoindole derivative to emit green fluorescence, thereby realizing the detection of carbamate pesticides based on the ratio fluorescence principle. The nanosensor relies on the fluorescence open-type response detection signal, presenting a significant change from bright red to green fluorescence, having a good visualization effect, and having high sensitivity, good selectivity, strong anti-interference ability, and low detection limit.

The invention discloses low-temperature cutinase CtCut derived from marine fungi and capable of efficiently degrading PU and PET plastics and application of the low-temperature cutinase CtCut. The amino acid sequence of the low-temperature cutinase CtCut is shown as SEQ ID NO. 2, and the nucleotide sequence of the low-temperature cutinase CtCut is shown as SEQ ID NO. 1. The CtCut can degrade various polyurethanes (PU) such as polyester type PU ImpranilTMDLN, polyether type PU foam and PBA-PU at the temperature of 35 DEG C, and also has a degradation effect on polyethylene glycol terephthalate (PET). The CtCut can efficiently break ester bonds in PET, ester bonds in a PU soft segment and carbamate bonds in a PU hard segment. The cutinase CtCut has substrate heterogeneity, can efficiently degrade PET (Polyethylene Terephthalate) and PU (Polyurethane) plastics, and can provide theoretical guidance and technical support for recycling various types of PU and mixed plastics in the future.

The present disclosure is concerned with substituted cyclopropyl carbamate and cyclopropyl sulfonamide compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of various cancers such as, for example, cancers comprising cells that express at least one Sox 2 stem cell marker. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present invention relates to carbamate compounds of formula (I), as further detailed herein, for use in inhibiting the SARM1 protein, as well as compositions comprising these compounds and methods of treatment by administration of the compounds and compositions.

The present invention relates to an emulsion formulation comprising thiencarbazone-methyl or a pesticide-acceptable salt thereof, one or more organic water-immiscible solvents, one or more organic water-miscible solvents selected from linear and cyclic carbamate esters, one or more emulsifiers, and one or more organic bases, wherein the formulation exhibits a pH of 5.5 to 9.

The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, ester, amide or carbamate thereof, or a salt of such an ester, amide or carbamate. The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy.

This invention belongs to the field of oil and gas well exploration and development technology, specifically relating to a high-temperature sealing thread grease for oil casing and its preparation method and application. The thread grease comprises the following components in parts by weight: 33-58 parts base grease, 10-40 parts magnetic fluid, 1-5 parts polyethylene glycol, 5-10 parts phosphate ester, 4-10 parts fumed silica, 3-18 parts graphite, 1-5 parts nano-molybdenum powder, 1-5 parts nano-copper powder, 6-12 parts zinc powder, 10-30 parts lead powder, 5-10 parts alkylphenol resin, 5-15 parts acrylic resin, 5-15 parts polytetrafluoroethylene, 10-18 parts diisocyanate, 10-18 parts polyurethane, 10-12 parts tetraethylene glycol dimethacrylate, and 6-11 parts nitrile rubber. This invention ensures good lubricity while maintaining excellent sealing performance under high-temperature conditions.

The invention discloses a diesel engine lubricating oil composition and a preparation method thereof, and the diesel engine lubricating oil composition comprises the following components by mass: 5.0%-7.5% of a high temperature detergent, 2.5%-5.4% of a bis-succinimide dispersant, 0.5%-2.0% of a zinc dialkyl dithiophosphate antioxidant preservative, 0.5%-1.5% of an auxiliary antioxidant, 0.5%-1.5% of a 2, 3-dihydro-2, 3, 4-trimethyl-1, 3-pentanediol monoisobutyrate, 0.5%-1.5% of a 2, 3, 4-trimethyl-1, 3-pentanediol monoisobutyrate, 0.5 The lubricating oil composition is prepared by uniformly stirring the following components in percentage by weight: 0.5 to 2.0 percent of 2, 2-dimethyl-7-benzofuryl-A-N-carbamate, 0.2 to 0.5 percent of pour point depressant, 0.0015 to 0.0050 percent of methyl silicone oil anti-foaming agent and the balance of catalytic hydrogenation base oil at the temperature of between 60 and 70 DEG C. The lubricating oil composition can be prepared by uniformly stirring the components at the temperature of between 60 and 70 DEG C. According to the diesel engine oil composition, various components are reasonably compounded, so that mutual inhibition of marine diesel engine oil water separation property, additive washing resistance, detergency and dispersibility, oxidation resistance, wear resistance and the like is solved, and the oil change period of an oil product is greatly prolonged.

The invention belongs to the technical field of lithium ion battery energy storage materials, and particularly relates to a boron ester bond / hydrogen bond synergistic self-repairing polymer electrolyte as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, jointly dissolving fluoroalcohol, allyl isocyanate, polycaprolactone glycol and a first initiator in an electrolyte, carrying out nucleophilic addition reaction to obtain an intermediate solution containing a carbamate group, then adding lithium salt into the intermediate solution containing the carbamate group, and carrying out polymerization reaction to obtain the lithium ion battery. The preparation method comprises the following steps: adding a boron ester monomer and a first initiator, uniformly mixing, adding a boric acid ester monomer and a second initiator, carrying out an addition reaction to form a self-repairing precursor solution, heating the self-repairing precursor solution, and carrying out in-situ polymerization to obtain the boron ester bond / hydrogen bond synergistic self-repairing polymer electrolyte. The boron ester bond / hydrogen bond synergistic self-repairing polymer electrolyte prepared by the invention can repair cracks or electrode deformation generated in a circulation process, contains rich fluorine elements, and can improve an electrochemical window of a self-repairing solid electrolyte.

The present invention provides a thyroid hormone receptor β (TRβ) agonist compound, a preparation method and an application thereof. The compound and the pharmaceutically acceptable salts, esters, amides or carbamates, as well as isomers, racemates, prodrugs, co-crystallized complexes or solvates of the compound can be used as thyroid hormone receptor β agonists, and the prepared thyroid hormone receptor β agonist has a good activation effect on wild-type and mutant thyroid hormone receptor β, has a weak effect or basically no effect on thyroid hormone receptor α (TRα) and prolyl hydroxylase (PHD2) targets, and has good selectivity. Therefore, the compound can be used in the prevention or treatment of thyroid hormone receptor β-mediated related diseases.

The invention belongs to the field of gene engineering, and particularly relates to a PU hydrolase UMG-SP1 mutant with high catalytic activity and application thereof. The amino acids at the 126, 173, 202, 364, 302, 172, 178, 89, 129, 298, 79 and 201 sites in the amino acid sequence of the PU depolymerases as shown in SEQ ID NO: 1 are mutated by using structural analysis and site-specific mutagenesis technologies to obtain a plurality of mutants, and the mutants with improved catalytic activity are obtained. Experiments prove that the PU depolymerization mutants improve the degradation capacity of PU plastic by promoting the hydrolysis efficiency of carbamate bonds in PU, and an important degrading enzyme element is provided for developing an efficient and environment-friendly PU plastic enzymatic degradation technology.

The present invention relates to a method for treating or preventing obesity in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds. The invention further relates to methods for reducing body weight and / or reducing food intake in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.

The invention provides an isophorone dicarbamate refining and purifying device and a purifying method. The device sequentially comprises a flash tank, a filter, a solvent separating tower, a carbonyl esterifying agent separating tower, a cooler, a phase separating tank, a centrifugal machine I, a washing kettle, a washing water separating tank, a centrifugal machine II and a drying machine which are communicated with one another, according to the purification method, an intermediate IPDC mixed solution is sequentially subjected to the procedures of flash evaporation, filtration, solvent separation, carbonyl esterification agent separation, cooling, liquid phase separation, washing, drying and the like through the purification device, high-purity refined IPDC is obtained, industrial continuous production can be achieved, the product purity is high, the purification efficiency is high, and the cost is low.

The following provides compounds represented by the following structures, or their tautomers, stereoisomers, hydrates, solvates, pharmaceutically acceptable salts, or prodrugs, which can be used as agonists of AT2R. JPEG2026529114000149.jpg5645

The invention discloses an anticorrosive coating for a dam panel and a preparation process of the anticorrosive coating, and belongs to the technical field of surface treatment and coatings. The anticorrosive paint is prepared from the following raw materials: 30 to 45 parts of isophorone diisocyanate modified epoxy resin, 15 to 24 parts of carbamate modified epoxy vinyl ester resin, 25 to 35 parts of VITEL copolyester resin, 3 to 8 parts of a curing agent, 20 to 30 parts of pigment and filler, 1 to 3 parts of a functional auxiliary agent and a sufficient amount of a solvent. A coating composite resin system is constructed by adopting various resins and corresponding modification treatment, the high-performance anti-corrosion coating is finally prepared, the high-performance anti-corrosion coating has high cohesiveness and excellent weather resistance, chemical corrosion resistance and durability stability, the anti-corrosion requirement of a dam panel water level amplitude variation area can be met, the service life of the dam panel water level amplitude variation area is prolonged, the maintenance cost is reduced, and the service life of the dam panel water level amplitude variation area is prolonged. And the safety and the stability of the water conservancy project are effectively ensured.

The invention relates to a calixarene filler-based composite gel electrolyte and an in-situ preparation method thereof. The in-situ preparation method comprises the following steps: S1, carrying out carbamic acid esterification addition reaction on PEO and IEM under the action of a catalyst to obtain PEO-IEM; and S2, mixing the PEO-IEM, acrylate, calixarene and the electrolyte, adding an initiator to initiate a free radical polymerization cross-linking reaction between the PEO-IEM and the acrylate, and forming a three-dimensional cross-linked network wrapping the electrolyte and calixarene to obtain the calixarene filler-based composite gel electrolyte. The lithium ion transference number and the ionic conductivity of the composite gel electrolyte can be remarkably improved, so that the electrolyte can still keep excellent long-term cycling stability under a high-load battery system, and a reliable electrolyte solution is provided for industrialization of high-safety and high-energy-density lithium metal batteries.

The present invention discloses a lead-zinc ore zinc collector and its preparation method and application. The lead-zinc ore zinc collector is calculated by weight and includes: 50 to 90 parts of N, N-dialkyl dithiocarbamate, 8 to 35 parts of alkyl dithiophosphate thioether ester, 2 to 6 parts of octanol, and 3 to 12 parts of non-polar oil; the non-polar oil includes one or two of kerosene and diesel. The present invention uses N, N-dialkyl dithiocarbamate, alkyl dithiophosphate thioether ester, octanol and non-polar oil as raw materials, and prepares the lead-zinc ore zinc collector by regulating the amount of each raw material, especially regulating the ratio of octanol and non-polar oil, thereby improving the flotation effect and zinc grade of zinc in the ore. In addition, the preparation method of the lead-zinc ore zinc collector has the advantages of simple operation, low cost, short production cycle, etc., and can realize industrial large-scale production, thereby promoting the development of the zinc ore dressing industry.

This invention provides spirocyclic compounds as inhibitors of KRASG12D mutants, including compounds, pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. The invention also provides pharmaceutical compositions comprising said compounds and their use in the treatment of cancer.

An enzymatic method for the production of an L-glufosinate P-alkyl ester can be performed. This method is characterized by reacting an L-glufosinate P-alkyl ester carbamoylate to give the corresponding L-glufosinate P-alkyl ester. This is catalyzed by a carbamoylase. The L-glufosinate P-alkyl ester carbamoylate employed may be obtained by a reaction from the corresponding L-glufosinate hydantoin P-alkyl ester. This is catalyzed by a hydantoinase, preferably an L-enantioselective hydantoinase. In a second aspect, an enzymatic method for enantioselective production of an L-glufosinate P-alkyl ester from a mixture MIIIA of L- and D-glufosinate P-alkyl ester hydantoins can be performed. The L-glufosinate P-alkyl ester obtained in the methods according to the first or second aspect of the invention may be saponified to give L-glufosinate.

The invention provides easy-to-remove photocuring ink and a display ink removal repair method. The light-cured ink easy to remove comprises 10 to 60 parts of aliphatic epoxy resin; 1 to 10 parts of oxetane resin; 5 to 10 parts of carbon black; 10 to 30 parts of a small molecular ether ester organic solvent; 0.1 part to 0.5 part of a flatting agent; 0.1 to 1 part of a defoaming agent; 1-3 parts of a coupling agent; 0.1 to 2 parts of a photoinitiator; 0.1 to 0.5 part of a carbamate oxygen heterocyclic delayed curing agent; wherein the easy-to-remove photocuring ink is used for forming an easy-to-remove ink layer after illumination operation, so that the difficulty in manual removal is reduced. According to the light-cured ink, the carbamate oxygen heterocyclic delayed curing agent and the small molecular ether ester organic solvent are matched for use, so that the condition that the finally prepared ink layer meets the performance requirements of a display can still be ensured on the premise of reducing the use amount of the flatting agent; and it is also ensured that an operator can comprehensively, rapidly and traceless remove the poor easy-to-remove ink layer in a labor-saving mode.

The present invention relates to the technical field of molecular imaging probes, and more specifically to a fluorescent probe targeting the estrogen receptor, a preparation method, and applications thereof. The fluorescent probe targeting the estrogen receptor is composed of a fluorescein ester, an estrogen receptor recognition group, raloxifene, and an alkane chain. The preparation method comprises the following steps: Step S1, hydrolyzing or hydrogenolyzing the carbamate of raw material I to synthesize an amino intermediate II; Step S2, condensing the amino intermediate II with FITC to obtain a fluorescent probe targeting the estrogen receptor III. The fluorescent probe targeting the estrogen receptor in the present invention can avoid the effects of short emission wavelength and low signal-to-noise ratio during probe application, and can be better used to promote the clinical application of the fluorescent probe targeting the estrogen receptor.