63 results about "Carbamate esters" patented technology

The invention discloses a dithiocarbamate monomer, a holographic recording medium, a preparation method and a related device, the structural general formula of the monomer is as shown in G1 and G2, R1 represents any one of hydrogen, halogen and C1-C4 alkyl, R3 represents any one of hydrogen, halogen and C1-C4 alkyl, A1 represents C1-C4 alkyl, A2 represents hydrogen or methyl, n is a positive integer, and n = 1-10. The dithiocarbamate monomer provided by the invention has high refractive index, and the holographic recording medium with high sensitivity, high diffraction efficiency and high refractive index modulation degree can be obtained by applying the dithiocarbamate monomer to preparation of the photopolymer holographic recording medium; holographic recording media can be used to prepare volume holographic gratings, holographic optical elements, and optical devices.

The invention provides a synthetic method and application of pure water-based acrylic resin. The preparation method comprises the following steps: firstly, esterifying acrylic acid and fatty alcohol to prepare an acrylate monomer with a flexible chain segment and hydrophilic-hydrophobic balance; then, acrylic ester and diethanol amine are subjected to aminolysis to generate a hydroxyl-containing acrylamide derivative, hydroxyl and trimethylolpropane ester exchange is carried out to form a branched node, and the crosslinking potential of a molecular chain is increased; the hydroxyl group and the isocyanate group are combined to generate a carbamate hard segment and construct a hyperbranched skeleton, and meanwhile, double bonds are reserved for subsequent free radical polymerization; and finally, copolymerizing the flexible monomer, the hyperbranched hard-segment monomer and hydroxyethyl acrylate to form the composite resin containing high-density hydroxyl groups, wherein the soft and hard segments of the composite resin are microphase-separated. The pure water-based acrylic resin prepared by the invention has excellent adhesive force, weather resistance, solvent resistance and the like, is applied to baking varnish, effectively improves the performance of the baking varnish, and has the characteristics of being green and environment-friendly.

The invention discloses a carbamate compound, lipid nanoparticles constructed by the carbamate compound, a pharmaceutical composition and application of the carbamate compound. A lipid nanoparticle carrier constructed by the series of cationic amino lipid compounds (formula I) can deliver mRNA to the spleen in a targeted manner on the premise of ensuring high efficiency and low toxicity, so that the immune response is effectively stimulated, the curative effect is remarkably improved, and the cationic amino lipid compound has important clinical application significance in cancer treatment.

The invention discloses low-temperature cutinase CtCut derived from marine fungi and capable of efficiently degrading PU and PET plastics and application of the low-temperature cutinase CtCut. The amino acid sequence of the low-temperature cutinase CtCut is shown as SEQ ID NO. 2, and the nucleotide sequence of the low-temperature cutinase CtCut is shown as SEQ ID NO. 1. The CtCut can degrade various polyurethanes (PU) such as polyester type PU ImpranilTMDLN, polyether type PU foam and PBA-PU at the temperature of 35 DEG C, and also has a degradation effect on polyethylene glycol terephthalate (PET). The CtCut can efficiently break ester bonds in PET, ester bonds in a PU soft segment and carbamate bonds in a PU hard segment. The cutinase CtCut has substrate heterogeneity, can efficiently degrade PET (Polyethylene Terephthalate) and PU (Polyurethane) plastics, and can provide theoretical guidance and technical support for recycling various types of PU and mixed plastics in the future.

The present disclosure is concerned with substituted cyclopropyl carbamate and cyclopropyl sulfonamide compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of various cancers such as, for example, cancers comprising cells that express at least one Sox 2 stem cell marker. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present invention relates to carbamate compounds of formula (I), as further detailed herein, for use in inhibiting the SARM1 protein, as well as compositions comprising these compounds and methods of treatment by administration of the compounds and compositions.

The present invention relates to an emulsion formulation comprising thiencarbazone-methyl or a pesticide-acceptable salt thereof, one or more organic water-immiscible solvents, one or more organic water-miscible solvents selected from linear and cyclic carbamate esters, one or more emulsifiers, and one or more organic bases, wherein the formulation exhibits a pH of 5.5 to 9.

The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, ester, amide or carbamate thereof, or a salt of such an ester, amide or carbamate. The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy.

This invention belongs to the field of oil and gas well exploration and development technology, specifically relating to a high-temperature sealing thread grease for oil casing and its preparation method and application. The thread grease comprises the following components in parts by weight: 33-58 parts base grease, 10-40 parts magnetic fluid, 1-5 parts polyethylene glycol, 5-10 parts phosphate ester, 4-10 parts fumed silica, 3-18 parts graphite, 1-5 parts nano-molybdenum powder, 1-5 parts nano-copper powder, 6-12 parts zinc powder, 10-30 parts lead powder, 5-10 parts alkylphenol resin, 5-15 parts acrylic resin, 5-15 parts polytetrafluoroethylene, 10-18 parts diisocyanate, 10-18 parts polyurethane, 10-12 parts tetraethylene glycol dimethacrylate, and 6-11 parts nitrile rubber. This invention ensures good lubricity while maintaining excellent sealing performance under high-temperature conditions.

The invention belongs to the technical field of lithium ion battery energy storage materials, and particularly relates to a boron ester bond / hydrogen bond synergistic self-repairing polymer electrolyte as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, jointly dissolving fluoroalcohol, allyl isocyanate, polycaprolactone glycol and a first initiator in an electrolyte, carrying out nucleophilic addition reaction to obtain an intermediate solution containing a carbamate group, then adding lithium salt into the intermediate solution containing the carbamate group, and carrying out polymerization reaction to obtain the lithium ion battery. The preparation method comprises the following steps: adding a boron ester monomer and a first initiator, uniformly mixing, adding a boric acid ester monomer and a second initiator, carrying out an addition reaction to form a self-repairing precursor solution, heating the self-repairing precursor solution, and carrying out in-situ polymerization to obtain the boron ester bond / hydrogen bond synergistic self-repairing polymer electrolyte. The boron ester bond / hydrogen bond synergistic self-repairing polymer electrolyte prepared by the invention can repair cracks or electrode deformation generated in a circulation process, contains rich fluorine elements, and can improve an electrochemical window of a self-repairing solid electrolyte.

The invention belongs to the field of gene engineering, and particularly relates to a PU hydrolase UMG-SP1 mutant with high catalytic activity and application thereof. The amino acids at the 126, 173, 202, 364, 302, 172, 178, 89, 129, 298, 79 and 201 sites in the amino acid sequence of the PU depolymerases as shown in SEQ ID NO: 1 are mutated by using structural analysis and site-specific mutagenesis technologies to obtain a plurality of mutants, and the mutants with improved catalytic activity are obtained. Experiments prove that the PU depolymerization mutants improve the degradation capacity of PU plastic by promoting the hydrolysis efficiency of carbamate bonds in PU, and an important degrading enzyme element is provided for developing an efficient and environment-friendly PU plastic enzymatic degradation technology.

The following provides compounds represented by the following structures, or their tautomers, stereoisomers, hydrates, solvates, pharmaceutically acceptable salts, or prodrugs, which can be used as agonists of AT2R. JPEG2026529114000149.jpg5645

The invention relates to a calixarene filler-based composite gel electrolyte and an in-situ preparation method thereof. The in-situ preparation method comprises the following steps: S1, carrying out carbamic acid esterification addition reaction on PEO and IEM under the action of a catalyst to obtain PEO-IEM; and S2, mixing the PEO-IEM, acrylate, calixarene and the electrolyte, adding an initiator to initiate a free radical polymerization cross-linking reaction between the PEO-IEM and the acrylate, and forming a three-dimensional cross-linked network wrapping the electrolyte and calixarene to obtain the calixarene filler-based composite gel electrolyte. The lithium ion transference number and the ionic conductivity of the composite gel electrolyte can be remarkably improved, so that the electrolyte can still keep excellent long-term cycling stability under a high-load battery system, and a reliable electrolyte solution is provided for industrialization of high-safety and high-energy-density lithium metal batteries.

The present invention discloses a lead-zinc ore zinc collector and its preparation method and application. The lead-zinc ore zinc collector is calculated by weight and includes: 50 to 90 parts of N, N-dialkyl dithiocarbamate, 8 to 35 parts of alkyl dithiophosphate thioether ester, 2 to 6 parts of octanol, and 3 to 12 parts of non-polar oil; the non-polar oil includes one or two of kerosene and diesel. The present invention uses N, N-dialkyl dithiocarbamate, alkyl dithiophosphate thioether ester, octanol and non-polar oil as raw materials, and prepares the lead-zinc ore zinc collector by regulating the amount of each raw material, especially regulating the ratio of octanol and non-polar oil, thereby improving the flotation effect and zinc grade of zinc in the ore. In addition, the preparation method of the lead-zinc ore zinc collector has the advantages of simple operation, low cost, short production cycle, etc., and can realize industrial large-scale production, thereby promoting the development of the zinc ore dressing industry.

This invention provides spirocyclic compounds as inhibitors of KRASG12D mutants, including compounds, pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. The invention also provides pharmaceutical compositions comprising said compounds and their use in the treatment of cancer.

An enzymatic method for the production of an L-glufosinate P-alkyl ester can be performed. This method is characterized by reacting an L-glufosinate P-alkyl ester carbamoylate to give the corresponding L-glufosinate P-alkyl ester. This is catalyzed by a carbamoylase. The L-glufosinate P-alkyl ester carbamoylate employed may be obtained by a reaction from the corresponding L-glufosinate hydantoin P-alkyl ester. This is catalyzed by a hydantoinase, preferably an L-enantioselective hydantoinase. In a second aspect, an enzymatic method for enantioselective production of an L-glufosinate P-alkyl ester from a mixture MIIIA of L- and D-glufosinate P-alkyl ester hydantoins can be performed. The L-glufosinate P-alkyl ester obtained in the methods according to the first or second aspect of the invention may be saponified to give L-glufosinate.

The invention provides easy-to-remove photocuring ink and a display ink removal repair method. The light-cured ink easy to remove comprises 10 to 60 parts of aliphatic epoxy resin; 1 to 10 parts of oxetane resin; 5 to 10 parts of carbon black; 10 to 30 parts of a small molecular ether ester organic solvent; 0.1 part to 0.5 part of a flatting agent; 0.1 to 1 part of a defoaming agent; 1-3 parts of a coupling agent; 0.1 to 2 parts of a photoinitiator; 0.1 to 0.5 part of a carbamate oxygen heterocyclic delayed curing agent; wherein the easy-to-remove photocuring ink is used for forming an easy-to-remove ink layer after illumination operation, so that the difficulty in manual removal is reduced. According to the light-cured ink, the carbamate oxygen heterocyclic delayed curing agent and the small molecular ether ester organic solvent are matched for use, so that the condition that the finally prepared ink layer meets the performance requirements of a display can still be ensured on the premise of reducing the use amount of the flatting agent; and it is also ensured that an operator can comprehensively, rapidly and traceless remove the poor easy-to-remove ink layer in a labor-saving mode.

The present invention relates to the technical field of molecular imaging probes, and more specifically to a fluorescent probe targeting the estrogen receptor, a preparation method, and applications thereof. The fluorescent probe targeting the estrogen receptor is composed of a fluorescein ester, an estrogen receptor recognition group, raloxifene, and an alkane chain. The preparation method comprises the following steps: Step S1, hydrolyzing or hydrogenolyzing the carbamate of raw material I to synthesize an amino intermediate II; Step S2, condensing the amino intermediate II with FITC to obtain a fluorescent probe targeting the estrogen receptor III. The fluorescent probe targeting the estrogen receptor in the present invention can avoid the effects of short emission wavelength and low signal-to-noise ratio during probe application, and can be better used to promote the clinical application of the fluorescent probe targeting the estrogen receptor.

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

This invention provides a lubricating oil and its application. The lubricating oil includes a base oil, detergent, antioxidant, dispersant, friction reducer, pour point depressant, and viscosity index improver. The friction reducer includes a carbamate and a phosphate ester as shown in Formula 1. The carbamate includes dibutyl dithiocarbamate, with a mass percentage of 0.2% to 0.5% for the dibutyl dithiocarbamate and a mass percentage of 0.1% to 0.3% for the phosphate ester. This lubricating oil possesses excellent high-temperature detergency, soot dispersibility, oxidation resistance, wear resistance, and low friction characteristics, and can simultaneously meet the lubrication requirements of engines and transmission systems, thus achieving standardization of oils used in engines and transmission systems.

The pharmaceutical composition for treating dementia, comprising a mephenesin analogue compound and / or a compound with a carbamate structure. A therapeutic drug that can fundamentally treat dementia without causing side effects, such as an increase / decrease in body weight, loss of appetite, sexual debility, and symptoms of withdrawal can be provided with the pharmaceutical composition defined in the present invention. Combining this pharmaceutical composition with other pharmaceutical compositions, including cholinesterase inhibitors, can provide the most certain treatment method according to the symptoms.

The invention provides a diesel engine lubricating oil composition and a preparation method thereof. The diesel engine lubricating oil composition of the present invention comprises: (A) a viscosity index improver; (B) a boronized ashless dispersant and / or a polyisobutylene succinate ashless dispersant; (C) sulfonate and / or sulfurized alkylphenate metal detergents; (D) zinc dialkyl dithiophosphate; (E) a dialkyl dithiocarbamate; (F) an amine type antioxidant; (G) a thiophenol ester type antioxidant; (H) lubricating base oil; wherein the viscosity index improver is a copolymer of methyl acrylic acid C8-C12 alkyl ester, methyl acrylic acid C13-C18 alkyl ester and N-vinyl imidazole. The diesel engine lubricating oil composition has excellent soot dispersion, wear resistance and high-temperature cleaning performance, and can meet the requirements of API CI-4, ACEA E4 and E7-grade high-performance diesel engine lubricating oil.

The invention relates to the technical field of medicinal chemistry, in particular to a preparation method of a lung-targeting tertiary amine modified honokiol derivative, which is characterized in that a series of novel derivatives are synthesized by introducing a tertiary amine ligand into honokiol molecules and adopting an ester bond, carbamate bond or ether bond covalent linkage mode. The water solubility and metabolic stability of honokiol are effectively improved, the in-vivo half-life period of honokiol is remarkably prolonged, the lung tissue targeting characteristic of the tertiary amine ligand is utilized, selective enrichment of the derivative in the lung is achieved, and the selectivity of the derivative in the lung is improved. Therefore, the technical problem that honokiol is difficult to reach and maintain an effective treatment concentration at a target site due to poor pharmacokinetic properties is solved. Wherein the ether bond connected derivative HM-16 shows excellent anti-tumor activity, good tolerance and prolonged in-lung residence time, and a potential candidate drug is provided for targeted therapy of lung cancer.

This invention belongs to the field of environmental science and relates to a method for the complete depolymerization of thermoplastic polyester polyurethane (PBA-PU) using a dual-enzyme approach. Specifically, PBA-PU is used as a substrate, and esterases PETase and Aes72 are added to initiate the depolymerization reaction. PETase hydrolyzes the ester bonds, while Aes72 primarily hydrolyzes the carbamate bonds. The two enzymes synergistically promote the complete depolymerization of PBA-PU. This invention utilizes a dual-enzyme approach to degrade PBA-PU, improving enzymatic hydrolysis efficiency while completely depolymerizing PBA-PU into the monomer MDA. The monomers generated after depolymerization can then be repolymerized or utilized for other high-value applications, thereby improving product utilization and enhancing the competitive advantage of enzymatic degradation of PBA-PU.

The application relates to a cyclic icariin amino acid ester prodrug and a salt thereof, and belongs to the technical field of medicines, and particularly relates to a cyclic icariin amino acid ester prodrug formed between cyclic icariin and amino acids, a pharmaceutically acceptable salt thereof, and preparation and application thereof. Specifically, the application combines the structural characteristics of cyclic icariin and the inherent advantages of prodrugs, covalently combines amino acids with a 3-hydroxyl group in the structure of cyclic icariin to form a series of cyclic icariin amino acid ester prodrugs. The compound can significantly improve the water solubility, permeability and metabolic stability of cyclic icariin, improve the bioavailability of the medicine, and better exert an anti-tumor effect.

This invention discloses an antibacterial and deodorizing blackout roller blind and its preparation method, relating to the field of blackout roller blind technology. First, modified functional fillers are prepared by esterification of the hydroxyl groups on the surfaces of activated nano-silver and activated nano-titanium dioxide with 3-bromopropionic acid. These modified functional fillers are then melt-blended and spun with nylon to prepare a functional base fabric. The introduction of silver and titanium dioxide functional fillers endows the functional base fabric with antibacterial and deodorizing functions. Second, using isocyanate-terminated polyurethane prepolymer as a binder, the functional base fabric, the blackout layer, and the functional base fabric are bonded into a three-layer structure. Ethanolamine vapor is then introduced for curing to prepare the antibacterial and deodorizing blackout roller blind. The ethanolamine vapor can react with the halogenated hydrocarbons on the surface of the functional fillers to obtain amino-containing derivatives, further improving the antibacterial properties of the roller blind. It can also undergo a carbamate reaction with the isocyanate-terminated polyurethane prepolymer binder to form a three-dimensional network cross-linked structure, which is then cured, enhancing the bonding performance of the three-layer structure.

The invention relates to a fluorescence detection reagent for on-site rapid classification and identification of synthetic cannabinoid. According to the detection reagent, based on a steric hindrance engineering thermodynamic gating strategy, a fluorescent probe molecule tert-butyl (4-(2-(4-hydroxybutyl)-1, 3-dioxo-2, 3-dihydro-1H-benzo [de] isoquinoline-6-yl) phenyl) carbamate containing a specific steric hindrance group (Boc group) is designed and synthesized. And the probe forms a fluorescence quenching aggregate in a thermodynamic metastable state in a system. The aggregate constructs a specific energy threshold value, and only when the aggregate encounters synthetic cannabinoid of a high affinity category (simultaneously having a keto / ester head and a hydrophobic tail chain), dissociation of the aggregate is synergistically triggered through multiple non-covalent interaction, and a remarkable fluorescent lightening signal is generated. The response time is less than 1 s, the detection limit can reach the microgram level, and the method has the characteristics of simplicity and convenience in operation, strong anti-interference performance (no false positive), convenience in visual observation and the like. The problem that a traditional single-molecule probe is difficult to classify and identify synthetic cannabinoid in a complex matrix is solved, and powerful technical support is provided for on-site investigation of drugs.

The present invention discloses a diesel engine lubricating oil composition and a preparation method thereof. The composition comprises the following components, measured by mass percentage: 5.0% to 7.5% of a high-temperature detergent, 2.5% to 5.4% of a bis-succinimide dispersant, 0.5% to 2.0% of a zinc dialkyl dithiophosphate antioxidant and preservative, 0.5% to 1.5% of an auxiliary antioxidant, 0.5% to 2.0% of 2,3-dihydro-2,2-dimethyl-7-benzofuranyl-methyl-N-ylcarbamate, 0.2% to 0.5% of a pour point depressant, 0.0015% to 0.0050% of a methyl silicone oil antifoaming agent, and the balance being a catalytic hydrogenation base oil. The lubricating oil composition is prepared by uniformly stirring the above components at 60 to 70° C. The present invention solves the mutual inhibition between the water separation property of ship diesel engine oil, the water washability of additives, and the detergency, dispersibility, antioxidant properties, and wear resistance, by rationally compounding the various components, thereby greatly extending the oil change cycle of the oil product.

RA1 for use in the treatment of diseases or conditions in which activation of the AT2 receptor is desired or required, but inhibition of CYP is undesirable. 1 , R 2 , R 3 , R 4 , R 5 and Z is as defined herein. Such compounds are particularly useful in the treatment of autoimmune and / or fibrotic diseases, including interstitial lung diseases, such as idiopathic pulmonary fibrosis and sarcoidosis. [Formula 1] JPEG2023518474000016.jpg87170