38 results about "Carbamate esters" patented technology

The invention discloses a dithiocarbamate monomer, a holographic recording medium, a preparation method and a related device, the structural general formula of the monomer is as shown in G1 and G2, R1 represents any one of hydrogen, halogen and C1-C4 alkyl, R3 represents any one of hydrogen, halogen and C1-C4 alkyl, A1 represents C1-C4 alkyl, A2 represents hydrogen or methyl, n is a positive integer, and n = 1-10. The dithiocarbamate monomer provided by the invention has high refractive index, and the holographic recording medium with high sensitivity, high diffraction efficiency and high refractive index modulation degree can be obtained by applying the dithiocarbamate monomer to preparation of the photopolymer holographic recording medium; holographic recording media can be used to prepare volume holographic gratings, holographic optical elements, and optical devices.

The invention discloses low-temperature cutinase CtCut derived from marine fungi and capable of efficiently degrading PU and PET plastics and application of the low-temperature cutinase CtCut. The amino acid sequence of the low-temperature cutinase CtCut is shown as SEQ ID NO. 2, and the nucleotide sequence of the low-temperature cutinase CtCut is shown as SEQ ID NO. 1. The CtCut can degrade various polyurethanes (PU) such as polyester type PU ImpranilTMDLN, polyether type PU foam and PBA-PU at the temperature of 35 DEG C, and also has a degradation effect on polyethylene glycol terephthalate (PET). The CtCut can efficiently break ester bonds in PET, ester bonds in a PU soft segment and carbamate bonds in a PU hard segment. The cutinase CtCut has substrate heterogeneity, can efficiently degrade PET (Polyethylene Terephthalate) and PU (Polyurethane) plastics, and can provide theoretical guidance and technical support for recycling various types of PU and mixed plastics in the future.

The present invention relates to carbamate compounds of formula (I), as further detailed herein, for use in inhibiting the SARM1 protein, as well as compositions comprising these compounds and methods of treatment by administration of the compounds and compositions.

The present invention relates to an emulsion formulation comprising thiencarbazone-methyl or a pesticide-acceptable salt thereof, one or more organic water-immiscible solvents, one or more organic water-miscible solvents selected from linear and cyclic carbamate esters, one or more emulsifiers, and one or more organic bases, wherein the formulation exhibits a pH of 5.5 to 9.

The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, ester, amide or carbamate thereof, or a salt of such an ester, amide or carbamate. The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy.

This invention belongs to the field of oil and gas well exploration and development technology, specifically relating to a high-temperature sealing thread grease for oil casing and its preparation method and application. The thread grease comprises the following components in parts by weight: 33-58 parts base grease, 10-40 parts magnetic fluid, 1-5 parts polyethylene glycol, 5-10 parts phosphate ester, 4-10 parts fumed silica, 3-18 parts graphite, 1-5 parts nano-molybdenum powder, 1-5 parts nano-copper powder, 6-12 parts zinc powder, 10-30 parts lead powder, 5-10 parts alkylphenol resin, 5-15 parts acrylic resin, 5-15 parts polytetrafluoroethylene, 10-18 parts diisocyanate, 10-18 parts polyurethane, 10-12 parts tetraethylene glycol dimethacrylate, and 6-11 parts nitrile rubber. This invention ensures good lubricity while maintaining excellent sealing performance under high-temperature conditions.

The following provides compounds represented by the following structures, or their tautomers, stereoisomers, hydrates, solvates, pharmaceutically acceptable salts, or prodrugs, which can be used as agonists of AT2R. JPEG2026529114000149.jpg5645

The invention relates to a calixarene filler-based composite gel electrolyte and an in-situ preparation method thereof. The in-situ preparation method comprises the following steps: S1, carrying out carbamic acid esterification addition reaction on PEO and IEM under the action of a catalyst to obtain PEO-IEM; and S2, mixing the PEO-IEM, acrylate, calixarene and the electrolyte, adding an initiator to initiate a free radical polymerization cross-linking reaction between the PEO-IEM and the acrylate, and forming a three-dimensional cross-linked network wrapping the electrolyte and calixarene to obtain the calixarene filler-based composite gel electrolyte. The lithium ion transference number and the ionic conductivity of the composite gel electrolyte can be remarkably improved, so that the electrolyte can still keep excellent long-term cycling stability under a high-load battery system, and a reliable electrolyte solution is provided for industrialization of high-safety and high-energy-density lithium metal batteries.

This invention provides spirocyclic compounds as inhibitors of KRASG12D mutants, including compounds, pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. The invention also provides pharmaceutical compositions comprising said compounds and their use in the treatment of cancer.

The invention provides easy-to-remove photocuring ink and a display ink removal repair method. The light-cured ink easy to remove comprises 10 to 60 parts of aliphatic epoxy resin; 1 to 10 parts of oxetane resin; 5 to 10 parts of carbon black; 10 to 30 parts of a small molecular ether ester organic solvent; 0.1 part to 0.5 part of a flatting agent; 0.1 to 1 part of a defoaming agent; 1-3 parts of a coupling agent; 0.1 to 2 parts of a photoinitiator; 0.1 to 0.5 part of a carbamate oxygen heterocyclic delayed curing agent; wherein the easy-to-remove photocuring ink is used for forming an easy-to-remove ink layer after illumination operation, so that the difficulty in manual removal is reduced. According to the light-cured ink, the carbamate oxygen heterocyclic delayed curing agent and the small molecular ether ester organic solvent are matched for use, so that the condition that the finally prepared ink layer meets the performance requirements of a display can still be ensured on the premise of reducing the use amount of the flatting agent; and it is also ensured that an operator can comprehensively, rapidly and traceless remove the poor easy-to-remove ink layer in a labor-saving mode.

This invention provides a lubricating oil and its application. The lubricating oil includes a base oil, detergent, antioxidant, dispersant, friction reducer, pour point depressant, and viscosity index improver. The friction reducer includes a carbamate and a phosphate ester as shown in Formula 1. The carbamate includes dibutyl dithiocarbamate, with a mass percentage of 0.2% to 0.5% for the dibutyl dithiocarbamate and a mass percentage of 0.1% to 0.3% for the phosphate ester. This lubricating oil possesses excellent high-temperature detergency, soot dispersibility, oxidation resistance, wear resistance, and low friction characteristics, and can simultaneously meet the lubrication requirements of engines and transmission systems, thus achieving standardization of oils used in engines and transmission systems.

The pharmaceutical composition for treating dementia, comprising a mephenesin analogue compound and / or a compound with a carbamate structure. A therapeutic drug that can fundamentally treat dementia without causing side effects, such as an increase / decrease in body weight, loss of appetite, sexual debility, and symptoms of withdrawal can be provided with the pharmaceutical composition defined in the present invention. Combining this pharmaceutical composition with other pharmaceutical compositions, including cholinesterase inhibitors, can provide the most certain treatment method according to the symptoms.

The invention provides a diesel engine lubricating oil composition and a preparation method thereof. The diesel engine lubricating oil composition of the present invention comprises: (A) a viscosity index improver; (B) a boronized ashless dispersant and / or a polyisobutylene succinate ashless dispersant; (C) sulfonate and / or sulfurized alkylphenate metal detergents; (D) zinc dialkyl dithiophosphate; (E) a dialkyl dithiocarbamate; (F) an amine type antioxidant; (G) a thiophenol ester type antioxidant; (H) lubricating base oil; wherein the viscosity index improver is a copolymer of methyl acrylic acid C8-C12 alkyl ester, methyl acrylic acid C13-C18 alkyl ester and N-vinyl imidazole. The diesel engine lubricating oil composition has excellent soot dispersion, wear resistance and high-temperature cleaning performance, and can meet the requirements of API CI-4, ACEA E4 and E7-grade high-performance diesel engine lubricating oil.

The invention relates to the technical field of medicinal chemistry, in particular to a preparation method of a lung-targeting tertiary amine modified honokiol derivative, which is characterized in that a series of novel derivatives are synthesized by introducing a tertiary amine ligand into honokiol molecules and adopting an ester bond, carbamate bond or ether bond covalent linkage mode. The water solubility and metabolic stability of honokiol are effectively improved, the in-vivo half-life period of honokiol is remarkably prolonged, the lung tissue targeting characteristic of the tertiary amine ligand is utilized, selective enrichment of the derivative in the lung is achieved, and the selectivity of the derivative in the lung is improved. Therefore, the technical problem that honokiol is difficult to reach and maintain an effective treatment concentration at a target site due to poor pharmacokinetic properties is solved. Wherein the ether bond connected derivative HM-16 shows excellent anti-tumor activity, good tolerance and prolonged in-lung residence time, and a potential candidate drug is provided for targeted therapy of lung cancer.

This invention belongs to the field of environmental science and relates to a method for the complete depolymerization of thermoplastic polyester polyurethane (PBA-PU) using a dual-enzyme approach. Specifically, PBA-PU is used as a substrate, and esterases PETase and Aes72 are added to initiate the depolymerization reaction. PETase hydrolyzes the ester bonds, while Aes72 primarily hydrolyzes the carbamate bonds. The two enzymes synergistically promote the complete depolymerization of PBA-PU. This invention utilizes a dual-enzyme approach to degrade PBA-PU, improving enzymatic hydrolysis efficiency while completely depolymerizing PBA-PU into the monomer MDA. The monomers generated after depolymerization can then be repolymerized or utilized for other high-value applications, thereby improving product utilization and enhancing the competitive advantage of enzymatic degradation of PBA-PU.

This invention discloses an antibacterial and deodorizing blackout roller blind and its preparation method, relating to the field of blackout roller blind technology. First, modified functional fillers are prepared by esterification of the hydroxyl groups on the surfaces of activated nano-silver and activated nano-titanium dioxide with 3-bromopropionic acid. These modified functional fillers are then melt-blended and spun with nylon to prepare a functional base fabric. The introduction of silver and titanium dioxide functional fillers endows the functional base fabric with antibacterial and deodorizing functions. Second, using isocyanate-terminated polyurethane prepolymer as a binder, the functional base fabric, the blackout layer, and the functional base fabric are bonded into a three-layer structure. Ethanolamine vapor is then introduced for curing to prepare the antibacterial and deodorizing blackout roller blind. The ethanolamine vapor can react with the halogenated hydrocarbons on the surface of the functional fillers to obtain amino-containing derivatives, further improving the antibacterial properties of the roller blind. It can also undergo a carbamate reaction with the isocyanate-terminated polyurethane prepolymer binder to form a three-dimensional network cross-linked structure, which is then cured, enhancing the bonding performance of the three-layer structure.

The invention relates to a fluorescence detection reagent for on-site rapid classification and identification of synthetic cannabinoid. According to the detection reagent, based on a steric hindrance engineering thermodynamic gating strategy, a fluorescent probe molecule tert-butyl (4-(2-(4-hydroxybutyl)-1, 3-dioxo-2, 3-dihydro-1H-benzo [de] isoquinoline-6-yl) phenyl) carbamate containing a specific steric hindrance group (Boc group) is designed and synthesized. And the probe forms a fluorescence quenching aggregate in a thermodynamic metastable state in a system. The aggregate constructs a specific energy threshold value, and only when the aggregate encounters synthetic cannabinoid of a high affinity category (simultaneously having a keto / ester head and a hydrophobic tail chain), dissociation of the aggregate is synergistically triggered through multiple non-covalent interaction, and a remarkable fluorescent lightening signal is generated. The response time is less than 1 s, the detection limit can reach the microgram level, and the method has the characteristics of simplicity and convenience in operation, strong anti-interference performance (no false positive), convenience in visual observation and the like. The problem that a traditional single-molecule probe is difficult to classify and identify synthetic cannabinoid in a complex matrix is solved, and powerful technical support is provided for on-site investigation of drugs.

The invention discloses a fireproof coating for a new energy automobile power battery pack and a preparation method of the fireproof coating, and relates to the technical field of fireproof coating preparation. Comprising the following raw materials: a functional agent A, a functional agent B, a flame retardant, acrylic acid-polyurethane copolymer resin, fluorine modified acrylate, polyurethane microspheres, a dispersing agent, an antioxidant, polyether modified polysiloxane, hollow glass beads, boron nitride, a coalescing agent and deionized water. The flame retardant is added, ammonium polyphosphate serves as an acid source to be decomposed to generate phosphoric acid, pentaerythritol is catalyzed to be dehydrated into carbon, melamine and urea release ammonia gas to support expansion of a carbon layer, a compact expanded carbon layer is formed, the defect that the carbon layer of a traditional flame-retardant system is loose is overcome, it is ensured that the flame-retardant effect is stable and consistent, and the fire-resistant time of the coating is remarkably prolonged; the added functional agent A and the added functional agent B can achieve a synergistic effect, so that the compatibility among inorganic components is enhanced, and the heat insulation layer is prevented from collapsing at a high temperature.

The present invention relates to compounds that are cyclic carbamate and urea benzo-morpholine and benzo-thiomopoline derivatives of general formula (I) that inhibit the JAK family (JAK1, JAK2, JAK3 and TYK2) of non-receptor tyrosine protein kinases, methods for preparing the compounds, pharmaceutical compositions comprising the compounds, and therapeutic use thereof. The compounds of the present invention may be useful in the treatment of diseases or conditions associated with dysregulation of JAK family non-receptor kinases, particularly in the treatment of various inflammatory diseases including asthma, COPD, and other respiratory diseases.

The invention discloses a preparation method and application of a reactive diluent containing a dynamic intercalated urethane bond. The preparation method comprises the following steps: removing moisture from a monomer containing acetoacetate bonds and double bonds and polyether amine; adding polyether amine into the dehydrated monomer containing the acetoacetate bond and the double bond while stirring in a closed environment, and reacting for 2-4 hours at the temperature of 20-25 DEG C; and adding an excessive amount of water absorbent into the obtained product, and carrying out suction filtration to obtain the reactive diluent containing the dynamic intercalated carbamate bond. The obtained reactive diluent is low in viscosity, rich in raw material source, free of heating in the production process, capable of being generated through a one-step method, simple in process, low in cost and suitable for industrial production. The UV-LED (Ultraviolet-Light Emitting Diode) light-cured resin prepared by applying the active diluent containing the dynamic intercalated urethane bond has good degradability, mechanical property and reprocessing property.

This invention belongs to the field of photocurable polymer materials technology, specifically relating to a high-strength, wear-resistant resin composition and artificial nails. The composition comprises the following components in the indicated proportions: 100 parts by weight of modified polyurethane acrylate, 50-150 parts by weight of reactive diluent monomer, and 1-10 parts by weight of photoinitiator. The modified polyurethane acrylate is obtained by first-step carbamate reaction of cyclohexanehexyl alcohol with alicyclic or aromatic diisocyanate to obtain an isocyanate-terminated oligomer, followed by a second-step carbamate reaction with (meth)acrylate hydroxyl ester, resulting in a hexafunctional polyurethane acrylate with a clustered dispersion structure. Compared to conventional multifunctional polyurethane acrylates, the resulting composition exhibits higher photocuring efficiency, and the artificial nails prepared after curing have higher strength and wear resistance.

The present invention includes a novel class of MDMA carbamates that can be activated in vivo as prodrugs. The MDMA prodrugs of the invention are enzymatically cleaved in vivo and produce alcohols of low toxicity that are well tolerated and metabolized in humans.

The application belongs to the field of road engineering and discloses a composite high-performance cement-based grouting material for local disease repair excited by carbamate, which is characterized in that the adding amount of each component is as follows in terms of weight fraction: cement 45-50 parts; water 20-25 parts; composite polyurethane 2.0-2.5 parts; nano-silica ash 0.9-1.0 parts; fine sand 2.3-2.5 parts; water reducing agent 0.2-0.25 parts; and defoaming agent 0.2-0.25 parts. The application also discloses a preparation method. The application has the following main beneficial effects: the hydration reaction and hydration speed are improved, and the formation of early strength is promoted; the strength and interfacial bonding strength after hardening, the toughness and stability of the grouting material are improved, the bubble content in the grouting material is reduced, the brittle fracture of the road surface is effectively reduced, the cement mortar breaking strength is increased, the mixing is carried out at normal temperature, the required energy consumption is low, no waste gas is discharged, the strength after hardening is high, and the adaptability is good.

The invention relates to a catalyst composition. More specifically, the present invention relates to catalyst compositions comprising at least one alkyl bridge. The catalyst of the present invention has been demonstrated to provide higher filterability than a non-bridged catalyst when used in an ester reaction, and lower extractability than a non-bridged catalyst when used in a urethane reaction. The catalyst is expected to have the same catalytic activity for all ester bonds, carbamate bonds, silicone, siloxane and organic tin.

The invention belongs to the technical field of new dosage forms of pharmaceutical preparations and targeted delivery, and relates to a composite preparation of nanoparticles and inulin gel based on metabolic enzyme related icaritin prodrugs or pharmaceutically acceptable salts thereof, and a preparation method and application thereof. According to the invention, an icaritin carbamate prodrug or a pharmaceutically acceptable salt thereof is prepared into PLGA nanoparticles to improve the solubility of the icaritin carbamate prodrug, and the nanoparticles are embedded into inulin gel to construct an oral colon-targeted drug delivery system. And a new strategy and choice are provided for delivery of insoluble drugs and efficient treatment of inflammatory bowel diseases and complications thereof.

The invention relates to the technical field of functional finishing agents, and discloses a synthetic method and application of a polyester modified organic silicon functional finishing agent for terylene, and the synthetic method comprises the following steps: (1) synthesizing polyester modified organic silicon through ester exchange condensation polymerization; (2) carrying out end-capping modification on polyurethane; (3) emulsifying; from the perspective of the overall technical scheme, the matching of the components and the process control form a tight synergistic effect: the polyester chain segment provides a stable adhesion basis for the functional layer, and ensures that all functional groups do not fall off; the core is endowed with soft and smooth hand feeling by the organic silicon chain segment, and basic wearing comfort is met; the carbamate group reinforces the binding force and supplements the functions of stiffness, elasticity and perspiration at the same time, so that'softness without collapse and smoothness without stuffiness' are realized; and the polyester fabric has the comprehensive hand feeling of smoothness, softness, softness and elasticity at the same time.