The invention discloses a chiral diphosphine ligand based on a ferrocene framework and application thereof to asymmetric hydrogenation and correlated reactions. The novel chiral diphosphine ligand possesses a structure shown as a general formula I. In the general formula I, R1 is methyl, phenyl, t-butyl, hydroxyl and the like, R2 is ethyl, phenyl, cyclohexyl, p-mehtylphenyl, t-butyl, 3,5-dimethylphenyl, 3,5-di-t-butylphenyl, 3,5-di-t-butyl-4-methoxyphenyl, 2,6-dimethoxyphenyl, 2,6-dimethylphenyl and anthryl, and the bridging group between two phosphorus atoms is phenyl, naphthyl, alkyl and the like. Also, the invention discloses synthesis of the novel chiral diphosphine ligand and application of the chiral diphosphine ligand to prepare chiral medicines ibuprofen, naproxen and the like.