73 results about "Tert-Amyl alcohol" patented technology

The invention discloses a method of using lipase to catalyze and synthesize glucose-6-laurate on line. The method comprises the following steps: taking glucose and vinyl laurate as raw materials according to molar ratio of 1:8-12, taking 0.5-1.0 g of lipase Lipozyme TLIM as a catalyst, taking tert-amyl alcohol and DMSO (dimethyl sulfoxide) mixed solvent as a reaction solvent, uniformly filling the lipase Lipozyme TLIM into a reaction channel of a microfluidic channel reactor, wherein the inner diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4 mm, and the reaction channel is 0.5-1.0 m long, continuously introducing the raw materials and the reaction solvent into the reaction channel to perform acylation reaction, controlling the temperature of acylation reaction to be 40-55 DEG C, and keeping the acylation reaction for 15-35 min, on line collecting reaction liquid, and conventionally post-processing the reaction liquid to obtain glucose-6-laurate. The method has the advantages of short reaction time, high selectivity and high yield.

The invention discloses a method for on-line synthesizing glucose-6-acetate catalyzed by lipase. According to the method, glucose and vinyl acetate with a molar ratio being 1 : 16-22 are used as raw materials; 0.5-1.0 g of the lipase (Lipozyme TLIM) is used as a catalyst and a mixed solvent formed by tert-amyl alcohol and DMSO is used as a reaction solvent. The lipase (Lipozyme TLIM) is uniformly filled in a reaction channel of a microfluidic channel reactor, wherein the inner diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4 mm, and the length of the reaction channel is 0.5-1.0 m; the raw materials and the reaction solvent are continuously introduced into the reaction channel for an acylation reaction, wherein the temperature of the acylation reaction is controlled at 40-55 DEG C and the time of the acylation reaction is 15-35 min; a reaction liquid is collected on-line; and the glucose-6-acetate is obtained after the reaction liquid is subjected to conventional post-treatment. The method provided by the invention has the advantages of short reaction time, high selectivity and high yield.

The invention discloses a method for on-line synthesizing sucrose-6-palmitate catalyzed by a lipase. According to the method, sucrose and vinyl palmitate with a molar ratio being 1 : 3-8 are used as raw materials; 0.5-0.8 g of the lipase (Lipozyme TLIM) lipase is used as a catalyst and a mixed solvent formed by tert-amyl alcohol and DMSO is used as a reaction solvent. The lipase (Lipozyme TLIM) is uniformly filled in a reaction channel of a microfluidic channel reactor, wherein the inner diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4 mm, the length of the reaction channel is 0.5-1.0 m; the raw materials and the reaction solvent are continuously introduced into the reaction channel driven by an injection pump for an acylation reaction, wherein a temperature of the acylation reaction is controlled at 40-55 DEG C and the time of the acylation reaction is 20-40 min; a reaction liquid is collected on-line; and the sucrose-6-palmitate is obtained after the reaction liquid is subjected to conventional post-treatment. The method provided by the invention has the advantages of short reaction time, high selectivity and high yield.

The invention discloses a method for online synthesizing 5'-O-palmitoyl uridine in a lipozyme catalysis mode .The method includes the steps that dimethyl sulfoxide and tert-amyl alcohol with the volume ratio of 1:(8-16) serve as a reaction solvent, uridine and palmitic acid vinyl ester with the molar ratio of 1:(5-13) serve as raw materials, 0.5 g to 1.0 g of lipozyme TLIM serves as a catalyst, the raw materials and the reaction solvent are placed into an injector, a reaction channel of a microfluidics channel reactor is evenly filled with the lipozyme TLIM, and the raw materials and the reaction solvents are continuously led into a reaction channel device under pushing of an injection pump for an acylation reaction, wherein the inner diameter of the reaction channel of the microfluidics channel reactor is 0.8 mm to 2.4 mm, the length of the reaction channel is 0.5 m to 1.0 m, the temperature of the acylation reaction is controlled to be 15 DEG C to 50 DEG C, the concentration of the uridine in the reaction system is 0.03 mmol / mL to 0.07 mmol / mL, and the time of the acylation reaction is 20 min to 35 min; reacted liquid is online collected through a product collector and subjected to conventional aftertreatment, and the 5'-O-palmitoyl uridine is obtained .The method has the advantages of being short in reaction time and high in selectivity and yield.

The invention discloses a method for 5'-O-ethylene adipyl uridine online synthesis through lipase catalysis. The method comprises the steps that dimethyl sulfoxide and tert-amyl alcohol serve as reactive solvents, uridine and adipic acid divinyl ester serve as raw materials, and 0.5-1.0 g of a lipase, namely Lipozyme TLIM, serves as a catalyst, wherein the volume ratio of the dimethyl sulfoxide to the tert-amyl alcohol is 1:(8-16), and the molar ratio of the uridine to the adipic acid divinyl ester is 1:(5-13). The raw materials and the reactive solvents are placed into an injector, and a reaction passage of a microfluidic passage reactor is uniformly filled with the lipase, namely the Lipozyme TLIM. Under pushing of an injection pump, the raw materials and the reactive solvents are continuously pumped into the reaction passage for acylation reaction. The inner diameter of the reaction passage of the microfluidic passage reactor is 0.8-2.4 mm, the length of the reaction passage is 0.5-1.0 m, the acylation reaction temperature is controlled to be 15-50 DEG C, and the acylation reaction time is 20-35 min. Through a product collector, reactive solution online collection is conducted, and after a reactive solution is subjected to conventional after-treatment, 5'-O-ethylene adipyl uridine is obtained. The method for 5'-O-ethylene adipyl uridine online synthesis through lipase catalysis has the advantages that the reaction time is short, the selectivity is high, and the productive rate is high.

The invention discloses a method for synthesizing N-(5-sucrose ester valeryl)mexiletine online by lipozyme catalysis. The method takes N-(5-vinyl ester valeryl)mexiletine and sucrose as raw materials according to the amount of substance ratio of 1 to (1 to 10), dimethyl sulfoxide (DMSO) and tert-amyl alcohol as reaction solvents and lipozyme TL IM as a catalyst, and comprises the following steps: putting the raw materials and the reaction solvents into an injector; uniformly filling the lipozyme TL IM into a reaction channel of a micro-fluidic channel reactor; continuously introducing the raw materials and the reaction solvents into a reaction channel device under the pushing of the injector and carrying out esterification reaction, wherein the inner diameter of the reaction channel of the micro-fluidic channel reactor is 0.8mm to 2.4mm and the length of the reaction channel is 0.5m to 1.0m; controlling the reaction temperature to 20 DEG C to 60 DEG C and the reaction time to 20min to 40min; collecting a reaction solution online through a product collector and carrying out conventional post-treatment on the reaction solution to obtain the N-(5-sucrose ester valeryl)mexiletine. The method disclosed by the invention has the advantages of short reaction time, high selectivity and high yield.

The invention discloses a lipozyme-catalyzed on-line synthesizing method for 5'-O-ethylene hexanedioyl-5-methyluridine. The lipozyme-catalyzed on-line synthesizing method comprises the following steps that dimethyl sulfoxide and tert-amyl alcohol with the volume ratio being 1:8-16 are taken as a reaction solvent, 5-methyluridine and adipic acid divinyl ester with the molar ration being 1:5-13 are taken as raw materials, 0.5-1.0 gram of lipozyme TLIM is taken as a catalyst, the raw materials and the reaction solvent are placed in a syringe, a reaction channel of a microfluidic channel reactor is evenly filled with the lipozyme TLIM, the raw materials and the reaction solvent are continuously injected into the reaction channel for acylation reaction under driving of an injection pump, the inner diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4 mm, the length of the reaction channel is 0.5-1.0 m; and the temperature of the acylation reaction is controlled to be at 15-50 DEG C, the time for the acylation reaction is 20-35 minutes, a reaction solution is collected on line by a product collector, and the 5'-O-ethylene hexanedioyl-5-methyluridine is obtained after conventional treatment is conducted on the reaction solution. The lipozyme-catalyzed on-line synthesizing method has the advantages of being short in reaction time, high in selectivity and high in yield.

The invention discloses a manufacturing method of granular sodium tert-pentoxide, which comprises the following steps: taking metal sodium, tert-amyl alcohol and inert organic solvent as raw materials, pouring the tert-amyl alcohol and the inert solvent into a reaction kettle, further pouring the metal sodium into the reaction kettle, carrying out reflux reaction for 8-40h under the protection of nitrogen, evaporating the tert-amyl alcohol under normal pressure, decompressing to minus 0.08-minus 0.098MPa after the tert-amyl alcohol is completely evaporated, evaporating the residual inert organic solvent, then regulating the stirring rate of the reaction kettle to 10-80 turns / minute, decompressing and evaporating the inert organic solvent, cooling a remaining granular sodium tert-pentoxide product in the kettle to below 40 DEG C, and finally obtaining the required granular sodium tert-pentoxide. The manufacturing method can carry out production by utilizing general chemical equipment, the operation conditions are mild, the production process is simple, the used raw materials are convenient and easy to obtain, the product quality is stable and reliable, and the shelf life of the product can be effectively prolonged.