The invention discloses a high-performance multi-alloy wear-resistant ball, and a preparation process and a thermal treatment method thereof. The high-performance multi-alloy wear-resistant ball consists of the following components in percentage by weight: 2.0 to 2.6% of C, less than or equal to 1.0% of Si, 1.6 to 2.0% of Mn, more than or equal to 27% of Cr, 0.05 to 0.15% of Re, less than or equal to 0.05% of P, less than or equal to 0.05% of S, less than or equal to 0.3% of Mo, 0.1 to 0.3% of Ni, 0.05 to 0.08% of Al and the balance of Fe. When the high-performance multi-alloy wear-resistant ball is prepared, a metal mold sand coating process is adopted for formation, the thickness of a sand coating layer is controlled to be 1.5 mm to 3.5 mm, and the diameter of the wear-resistant ball is controlled to be phi 50 mm to phi 130 mm. According to the high-performance multi-alloy wear-resistant ball, and the preparation method and the thermal treatment method thereof, the high-performance multi-alloy wear-resistant ball obtained by adjusting the contents of C, Si, Mn, Cr, Re, P, S, Mo, Ni and Al elements, controlling the thickness of the sand coating layer in a preparation process and adjusting the thermal treatment method process in a thermal treatment process has high mechanical properties, strong impact toughness and small unit wear.