The invention provides an automatic liquid injection type vacuum edge bonding machine, comprising a cylinder, a work chamber and a worktable arranged in the work chamber, wherein a transition bin is arranged on one end of the work chamber, a rotary operating panel is arranged on the other end of the work chamber, and a conveyor belt and a feeding platform are arranged on the table top of the worktable. The automatic liquid injection type vacuum edge bonding machine further comprises a feeding mechanical arm, a liquid injection mechanism, a first degassing standing box, a second degassing standing box, a third degassing standing box and a vacuumizing edge bonding mechanism, which are arranged right above the conveyor belt and are connected in sequence. The automatic liquid injection type vacuum edge bonding machine provided by the invention is completely sealed by a high-performance sealing pad, and an inlet dehumidifying device is further arranged, thus the low temperature and low humidity environment in the machine and the process requirements in the liquid injection process are ensured, the operation automation degree is high, the machine operation is simple, only one operator is needed in the whole production process to manually feed and discharge materials, and the intermediate processes are all automatically finished by machines, therefore, the production efficiency is improved and influence of the complicated intermediate processes to the product quality is reduced.