The invention relates to a complex network optimization estimation method with stochastic coupling. The invention solves the problem that the existing state estimation method can not simultaneously process a stochastic occurrence coupling complex network with measurement loss phenomenon and inaccurate occurrence probability, As a result, the accuracy of estimation performance is low, as well as has the problem of low estimation performance accuracy when transmission data loss, transmission failure and coupling node failing to receive other node information occure at the same time. The processis as follows: 1. The dynamic model of stochastic coupling delay complex network is established; 2, state estimation of the dynamic model under the event-triggered protocol is carried out; 3, sigma i,k+1 | k is calculated; 4, Ki , k+1 are calculated; 5, xi,k+1|k=1 is obtained to judge whether k+1 equals to M, if k+1 < M, 6 is executed, otherwise the process is ended; 6, sigma i, k+1 | k+1 is calculated; k=k+1, 2 is executed until k+1=M is satisfied. The invention is used in the field of complex network optimization estimation.