The invention belongs to the field of medicine, and particularly relates to a yang locking wine and a preparation method thereof, wherein the yang locking wine has effects of blood circulation activating, blood stasis dissipating, liver and kidney nourishing, liver pacifying and liver yang suppressing. The technical problem solved by the present invention is to provide a drug composition with effects of blood circulation activating, blood stasis dissipating, liver and kidney nourishing, liver pacifying and liver yang suppressing, wherein the drug composition is prepared from the following bulk drugs by weight: 2-5 parts of maca, 0.5-2 parts of Chinese wolfberry, 0.5-2 parts of Tianshan Mountain chrysanthemum, 0.5-1 part of brassica campestris male flower, 0.5-1 part of tuber onion seed, 0.5-1 part of alpinia oxyphylla, 0.5-2 parts of polygonatum sibiricum, and 1-5 parts of honey, wherein the main drug maca acts on heart, liver and kidney, and has effects of kidney yang nourishing, heart and liver tonifying, yang assisting, and body fluid regeneration, and the Tianshan Mountain chrysanthemum with effects of blood circulation activating and yang moistening, the alpinia oxyphylla, the polygonatum sibiricum, the tuber onion seed with effects of kidney invigorating and yang assisting, and the brassica campestris bee pollen powder are assistedly used, such that the drug composition of the present invention has effects of blood circulation activating, blood stasis dissipating, liver and kidney nourishing, liver pacifying, liver yang suppressing, yin nourishing, dryness-syndrome moisturizing, refreshing and qi benefitting, and is suitable for sub-healthy men.