The invention belongs to the technical field of wastewater treatment, and particularly relates to a process for treating high-salt and high-concentration organic wastewater, which comprises the following steps of: S1, evaporation and concentration, S2, wastewater neutralization, S3, flocculent precipitation, S4, organic matter decomposition, S5, steam-water separation and S6, saline-water separation. According to the method, the existing high-salt and high-concentration organic wastewater treatment process flow is simplified, so that the wastewater treatment capacity is reduced, the treatment difficulty is reduced, and the wastewater treatment cost is remarkably reduced; and meanwhile, the problem that the quality of solid salt is reduced due to enrichment of high-salt-containing organic matters is solved, the whole process of removing the organic matters through evaporation desalination is continuously operated, the quality of the solid salt is improved, and the method can be widely applied to desalination treatment of high-salt wastewater in various industries.