The invention relates to hemodialysis water production equipment with a main machine capable of being thermally disinfected. The hemodialysis water production equipment comprises a raw water pump, a quartz sand filter, an activated carbon filter, a softening filter, a precision filter, a first heater, a balancer, a first-stage high-pressure pump, a first-stage reverse osmosis membrane system, a second-stage high-pressure pump, a second-stage reverse osmosis membrane system, a second heater, a hot disinfection water tank, a circulating pipeline and a ward pipeline. According to the hemodialysis water production equipment , a sanitary reverse osmosis membrane element capable of performing thermal disinfection is adopted, two heaters consisting of a plurality of electric heating rods are additionally arranged in the equipment to heat water flow in a pipeline, and hot water at 85-90 DEG C is adopted to perform thermal disinfection or chemical disinfection on a reverse osmosis system pipeline and a reverse osmosis membrane; through temperature compensation, an electric heater heats the water flow in the pipeline by 10-15 DEG C, so that the problem that the water yield of the reverse osmosis system is reduced due to too low temperature of tap water in winter is also solved; the host pipeline microbial and bacterial breeding problem is solved; and a new type of valve is adopted in an equipment pipeline, the mute effect is achieved, and the problem that equipment noise is large is solved.