The invention discloses a multifunctional pressure calibration device. The device comprises an upper computer, an electric pressure source, a pneumatic pressure controller, a PLC switch controller, agas-liquid isolator filter, a sealing cylinder, an electromagnetic shut-off valve, a filter, a detected meter interface, an electrical signal connection terminal, a multimeter, a direct-current powersupply, a hydraulic controller, an aviation oil sealing cylinder, an air pressure test stop valve, and a pneumatic spare part meter interface. All parts are connected by pressure pipelines and communication lines; the upper computer carries out system controlling; the electric pressure source generates the gas pressure needed by the system; the pneumatic pressure controller carries out low-range controlling and the hydraulic controller carries out high-pressure supplementing adjusting controlling; the gas pressure drives the sealing cylinder by the gas-liquid isolator filter, to carry out pressurizing on the detected meter interface; and the direct-current power supply provides an excitation power source for a detected pressure and the multimeter is used for carrying out outputting collection. According to the invention, the multifunctional pressure calibration device having advantages of simple operation and low cost is easy to implement and is capable of carrying out multi-medium, multi-range, multi-channel full-automatic calibration on different pressure testing devices.