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68 results about "Chemical computing" patented technology

Chemical computing is an unconventional approach to computation that uses a "soup" where data is represented by different concentrations of chemicals. Chemcial computing can be used to solve a range of problems. Chemical computers can exploit several different kinds of reaction to carry out the computation.

Synthesis of macrocyclic tetraamido-N ligands

New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an alpha or beta amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the alpha or beta amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.
Owner:CARNEGIE MELLON UNIV

Polyalkylene oxide polyquaternary ammonium biocides

ActiveUS20100158853A1High activityAmeliorating and reducing undesirable attributeBiocideOrganic active ingredientsHalogenMedicinal chemistry
Disclosed are polyquaternary ammonium polymers containing polyalkylene oxide groups according to formula (I) wherein [A]x, [B]y and [C]z are poly(alkylene oxides) each independently selected from the group consisting of poly(ethylene oxide), poly(propylene oxide), and poly(butylene oxide); Z is selected from the group consisting of —CH2CH═CHCH2—, —CH2CH2CH2CH2—, —CH2—C≡C—CH2—, —CH2CH2—O—CH2CH2—, —CH2—N(CH2CH2)2N—CH2—, —CH2CH(OH)CH(OH)CH2— and —CH2—C6H4—CH2—; R is —(CR1R2)mCR3R4— wherein m is an integer from 0 to 3 and R1, R2, R3 and R4 are independently selected from the group consisting of H, CH3 and CH2CH3; n is an integer from 1 to 30; x is either 0 or an integer from 2 to 20; y is an integer from 2 to 20; z is either 0 or an integer from 2 to 20; R′ is a branched or unbranched alkyl group having from 1 to 3 carbon atoms and is optionally substituted by one or two hydroxyl groups; Q1 and Q2 are independently selected from the group consisting of —CH2CH═CHCH2—X, —CH2C≡C—CH2—X, —N(R′)2, —N(R′)3, —N(R′)(R″), and —N(R′)2(R″), wherein X is a halogen atom and R″ is a benzyl group; and a stoichiometric amount of a pharmaceutically acceptable anion. Also disclosed are suitable methods of making the polymers, and methods of using the polymers.
Owner:ALCON INC

Method for producing crude sodium L-ascorbate by recovering crude vitamin C mother liquor

The invention discloses a method for producing crude sodium L-ascorbate by recovering crude vitamin C mother liquor. The method comprises the steps of: destaining crude vitamin C mother liquor through a macroporous adsorption resin, concentrating, crystallizing and centrifuging a destaining solution to obtain a crude vitamin C mother liquor recovered product, crushing and drying the mother liquor recovered product through a micro powder drying machine, performing esterification reaction with methanol, controlling the burdening ratio of mother liquor recovered product (weight) to methanol (volume) in the esterification reaction of 1: 7, reacting for 4 hours, wherein the esterification reaction temperature at the first hour is 68 DEG C, the esterification reaction temperature at the second hour is 60 DEG C, the esterification reaction temperature at the third hour is 55 DEG C and the esterification reaction temperature at the fourth hour is 50 DEG C, adding sodium bicarbonate with stoichiometric amount to perform conversion reaction to obtain intermediate crude sodium L-ascorbate, and then changing over to the production process of normal vitamin C. The production yield and quality of the crude sodium L-ascorbate are improved, the problem of the accumulation of a mother liquor recovered product is solved, and the production process is simplified.
Owner:DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD

Method for analyzing metabolites flux using converging ratio determinant and split ratio determinant

The present invention relates to a method for analyzing metabolic flux using CRD and SRD. Specifically, the method comprising: selecting a specific target organism, constructing the metabolic network model of the selected organism, identifying the correlations between specific metabolic fluxes in the metabolic network model, defining the correlation ratios as CRD and SRD, determining the correlation ratios of the metabolic fluxes through the experiment for measuring metabolic flux ratios, modifying a stoichiometric matrix with the determined CRD, SRD and correlation ratios, and applying the modified stoichiometric matrix of the metabolic network model for linear programming. According to the inventice method, the correlation between influent / effluent metabolic fluxes with respect to specific metabolites in target organisms (including E. coli), the genome-scale metabolic network model of which was constructed, can be determined as relative ratio using useful information obtained from various experiments, including a growth experiment using a radioactive isotope-labeled carbon source and an assay for measuring enzymatic reaction. Thus, limit values from various experiments can be effectively applied, so that internal metabolic flux can be quantified and analyzed in a more accurate and rapid manner.
Owner:KOREA ADVANCED INST OF SCI & TECH
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