The invention discloses a medical corrosion-resistance high-toughness 3D printing material which is prepared from the raw materials of ABS resin, SAN resin, butadiene rubber, chloroprene rubber, epoxy acrylic resin, polymethyl methacrylate, polycarbonate, polyolefin elastomer, sulphur, sulfur dichloride, chlorinated paraffin, dimethicone, zinc borate, isocyanate, nano graphite, carbon black, barite powder, nano aluminum hydroxide, polyphosphoric acid, nano silicon dioxide, mica powder, talcum powder, a silane coupling agent KH-560, sodium metaborate, pentaerythritol, polylactic acid, polycaprolactone, sodium stearate, sodium dodecyl benzene sulfonate, an antioxidant, a degassing agent, dimethicone, an anticorrosion additive, a modified filler and a toughening and modifying agent. The 3D printing material disclosed by the invention has excellent corrosion resistance and toughness.