A diatomaceous earth breathing brick with a high humidifying harm-reduction function and a production method thereof are disclosed, through improvement of a formula, slurry with excellent performances can be prepared, a molding material is prepared by a spray granulation process, and the molding problem is overcome. The formula comprises, (wt%), 80%-90% of diatomaceous earth; 4%-14% of clay; 0.5%-1.5% of talc; 0.5%-1% of a ceramic body enhancer; 1%-2% of a ceramic sintering aid agent; 0.5%-1% of a superplasticizer; 0.5%-1.5% of nano titanium dioxide and 0.5%-1.5% of tourmaline powder. The production method is as follows: the raw materials are prepared into the slurry by adding of water, and by spray granulation, material distribution, molding and firing, the diatomaceous earth breathing brick with the high humidifying harm-reduction function is obtained. Compared with the prior art, the formula and the molding process are improved, the use amount of the diatomaceous earth is significantly increased, body cracking, deformation, stratification and other phenomena caused by inappropriate moisture content of raw materials, uneven material distribution and excessive local stress of a green body can be avoided, and the diatomaceous earth breathing brick has a higher humidifying harm-reduction function.