The invention relates to an anti-fatigue traditional Chinese medicine composition tablet and a preparation method thereof. The traditional Chinese medicine composition tablet takes mutton, semen cuscutae, herba epimedii, rhizoma curculiginis, herba cistanche, glossy privet fruits, fructus schisandrae, fructus alpiniae oxyphyllae, fructus rubi, rhizoma drynariae, herba taxilli, prepared rehmannia roots, rhizoma polygonati, caulis dendrobii, radix ginseng, cornu cervi pantotrichum, radix astragali, radix codcnopsitis pilosulas, cortex phellodendri, fructus lycii and the like as primary medicines, and takes radix puerariae, poria, fructus jujubae, pericarpium citri tangerinae, fructus amomi, rhizoma atractylodis, rhizoma atractylodis macrocephalae, fructus tritici levis, arillus longan, rhizoma zingiberis and the like as auxiliary medicines. By pharmacological interaction between the primary medicines, the anti-fatigue traditional Chinese medicine composition tablet has the medicinal effects of tonifying the kidney and strengthening essence, nourishing the liver and improving eyesight, tonifying the spleen and benefiting the lung, and soothing the nerves and promoting intelligence, and can effectively relieve fatigue symptoms; and according to the preparation method of the traditional Chinese medicine composition tablet, the traditional Chinese medicine composition tablet is prepared through the ways of crushing, extracting, concentrating, granulating, tabletting and the like, and is easily absorbed by a human body, the good medicine effects of all the primary medicines are fully exerted, and then the purpose of relieving fatigue symptoms is accelerated.