The invention discloses peony health-care wine and a making method thereof. The preparation method of the peony health-care wine comprises the steps that wheat, corn, broomcorn millet, sweet potatoes, common yam rhizomes, radix puerariae, great burdock, radix paeoniae alba and cortex moutan are mixed and fermented, and fermentation liquor is obtained; peony flowers and paeonia lactiflora flowers are added for distillation, and a peony flower distillation wine fluid is obtained; peony flower petals, paeonia lactiflora flower petals, manyflower solomonseal rhizomes, poria cocos and fructus lycii are added, soaking is conducted for a period of time, filtering is conducted, and the peony health-care wine is obtained. The peony health-care wine is rich in fragrance of the flowers, mellow, delicious, rich in nutrition, strong in fragrance of the flowers, fragrant, sweet and golden yellow and transparent in color and luster, the peony flowers are matched with the paeonia lactiflora flowers, common yam rhizomes, radix puerariae, great burdock, radix paeoniae alba and cortex moutan, the effects of promoting blood circulation to remove meridian obstruction, invigorating the spleen to benefit the kidney, calming liver, improving eyesight, eliminating toxicity, keeping young, preventing senility, nourishing and strengthening a human body and the like are achieved, the degree of ordinary baijiu is greatly improved, the taste is improved, and the peony health-care wine is good for body health.