The present invention discloses a method for mechanical pulping with a cotton stalk, and the method is realized by the following steps that the method includes material preparation, dust removal and wire division, cooking, spraying, high concentration grinding, cleaning, black liquid removal, intermediate concentration grinding, screening and condensation, wherein, the dust removal and the wire division also include a first dust removal and wire division and a second dust removal and wire division, which are used to remove sand dust, impurity and core in the stalk completely. In the steps of material preparation, dust removal and wire division of the present invention, sufficient pretreatment is done for the cotton stalk to make fiber of the cotton stalk is fully grinded and refined. In the cooking, less chemical agent is added, which facilitates sewage treatment. The method in the present invention is more applicable for pulping of the cotton stalk, which realizes material preparation of the total cotton stalk, high pulping rate of the cotton stalk, the paper quality is improved and chemical composition in the waste liquid is low which is easy for treatment. The technology is optimized, and the power consumption and the production cost are reduced.