The invention discloses a spicy sesame peanut paste. The spicy sesame peanut paste is characterized in that the spicy sesame peanut paste is prepared from the raw materials of, by mass: 60 parts of peanut kernels, 15 parts of sesame, 8 parts of medlar, 8 parts of peach kernels, 4 parts of dry red peppers, 30 parts of soybean oil, 5 parts of sesame oil, 1 part of white granulated sugar, 5 parts of ginger, 5 parts of garlic, 10 parts of Sichuan peppers, 4 parts of salt, and 2 parts of monosodium glutamate. A preparation method of the spicy sesame peanut paste comprises the steps that: the sugar is added into soybean oil; the oil temperature is increased to 60-80 DEG C; the mixture is decocted for 2-3min; when the oil temperature is 100 DEG C, ginger, garlic, and the like are added; bake-dried peanut kernels are soaked in well-boiled Sichuan pepper water; the peanut kernels are dried by baking by using a slow fire; the sesame and peach kernels are stir-fried by using a slow fire, until a fragrance is generated; the sesame and peach kernels are prepared into coarse particles; the dry red peppers are well infused by using boiling water; the red peppers are dried by dipping, and is mixed with warm soybean oil; the red peppers are fried by using a slow fire, until a fragrance is generated; the Sichuan peppers are fried by using warm oil and a slow fire, until a fragrance is generated; the peanut kernels, peppers, Sichuan peppers, and salt are crushed into coarse particles; the coarse particles are decocted with the primer obtained by mixing for 5min; sesame oil is added to the mixture, and the mixture is decocted for 2min; and the mixture is fetched, and then filled.