The invention belongs to the technical field of health care beverages and especially relates to an immunity and memory enhancing health care oral solution preparation method. The preparation method specifically comprises the following steps: (1) weighing raw materials; (2) smashing snakehead bone, performing high-pressure steam treatment, roasting, taking out, grinding and smashing in a superfinemode to obtain snakehead bone meal; (3) mixing and pulping fresh dandelion leaf, fresh carrot top and water, boiling by soft fire, continuing to boil by soft fire, adding purple glutinous rice and rhubarb rice while hot, evenly stirring, fermenting, boiling by soft fire, pulping, fermenting, performing hyperfiltration and taking filtrate to obtain fermented rice leaf juice; (4) adding snakehead bone meal, oriental paperbush flower extractive, orange peel extractive and carnation extractive into the fermented rice leaf juice, evenly stirring and homogenizing; (5) obtaining a finished product. The finished product has refreshing and slightly-sweet taste, has refreshing smell, has no stimulation, can effectively enhance the human body immunity, can promote intestinal tract health, can resistcancer, prevent cancer, inhibit tumor cell growth and protect the liver, can effectively relieve cold hands and feet, can enhance memory ability and can improve life quality.