The invention discloses a multi-physical coupling method in transient calculation of a pressurized water reactor. The method comprises the following steps of 1, for a multi-group space-time neutron kinetics equation, obtaining neutron-flux density and delayed-neutron precursor density of a prediction step by using a fully-implicit backward difference method; 2, obtaining a shape function of the prediction step through a normalization condition, linearly interpolating the shape function in a medium time step, and by solving an amplitude function equation on a small time step, finally obtaining neutron-flux density on the medium time step, thereby obtaining power and delayed-neutron precursor density; and 3, performing fuel temperature calculation and coolant temperature calculation through the power in the medium time step, realizing feedback through a nuclear reaction cross section, and realizing coupling with neutronics calculation. When the neutronics calculation is performed by using an improved quasi-static method of prediction and correction, heat engineering calculation and delayed-neutron precursor density calculation are performed on the proper time step to realize efficient coupling.