The invention discloses a manufacturing method of low-alloy wear-resistance steel. The manufacturing method comprises the following steps of A, preparing, B, smelting, wherein a smelting furnace is vacuumized, and prepared materials are put in a vacuum smelting furnace for smelting; C, pouring; D, cooling, wherein after being subjected to air cooling, castings are subjected to water cooling, and acondensing device is adopted for condensing; E, annealing, wherein the castings are subjected to heating and heat preservation after being grinded, then temperature rising and heat preservation are conducted, and afterwards, quick water cooling is conducted; F, quenching, wherein the castings are heated, quenched, and timely tempered after being quenched. The manufacturing method has the following advantages that the content of carbon and the proportion of chromium to nickel to carbon are reasonably limited, other material components with a proper proportion are selected, and smelting is conducted after vacuumizing; so that the dissolving uniformity of a solution of the steel is good, cooling is conducted after casting, and the low-alloy wear-resistance steel is stepwise cooled in three modes after being poured; the casting quality is guaranteed, a manufactured protection plate has high hardness, tenacity, wear resistance, shock resistance and other performance, and meets all requirements for the mechanical performance in a shot blasting process, and the service life is prolonged.