33results about How to "Atomic economy" patented technology

The invention discloses a method for synthesizing a quindoline derivative by visible light catalysis. The method uses metal salt to synthesize the quindoline derivative through photocatalysis. According to the invention, extra photosensitizer is not required, cheap transition metal salt and secondary amine enable in-situ coordination to generate a compound which is taken as a photocatalyst, oxygen in air is taken as a terminal oxidizing agent, so that oxidation coupling of secondary amine and an indole derivative can be realized through a photochemical method, and the quindoline derivative enables one-step synthesis. The whole synthesis reaction has the advantages of mild condition, high efficiency, simple operation and atom economy.

The invention belongs to the field of chemical synthesis, and relates to a method for preparing a compound zolpidem. The invention provides an effective new method for preparing zolpidem by a trimaceral serially reaction. The method for preparing the zolpidem provided by the invention has the advantages that the reaction step is short, the condition is moderate, atom economy and environmentally friendly are achieved, the yield is high, the cost is low, industrialized production is applicable, and the defects in the prior art that the synthetic route is long and the cost is high are overcome.

The invention discloses a method for preparing an aniline derivative through visible light catalysis of acyl migration. The method comprises the following step: (1) adding enamine and alcohol into an organic solvent to obtain a solution A; (2) adding a photosensitizer into the solution A to obtain a solution B; and (3) in an air or oxygen atmosphere, irradiating the solution B with visible light to obtain a 1,2-acyl migrated aniline derivative. An acyl functional group in a substrate undergoes a 1,2-migration reaction under visible light catalysis; acyl-substituted, ester-substituted, arylamino-substituted and alkyl-substituted quaternary carbon compounds are synthesized at one step through a photochemical method, the whole synthesis reaction is mild in condition, operation is easy, and atom economy is realized; oxygen in the air is converted into an oxygen-containing functional group; and LED (Light-Emitting Diode) blue light or green light is taken as a visible light source, and operation is easy.

The invention provides an industrial production method of a furan derivative. The industrial production method is characterized in that a compound A and a cyanide are subjected to an addition reaction, and an oxidation reaction and a hydrolysis reaction are performed to obtain the target furan derivative. According to the present invention, the production method is simple and different from the complex production way and the stringent production conditions in the prior art; the synthesis of the target product can be achieved through the one step; and the production process and the synthesis route are optimized, such that the advantages of less side reaction, convenient post-treatment and mild production condition during the production process are provided, and the method is suitable for the industrial production mode.

The invention discloses a preparation method of brivaracetam, which adopts cheap and accessible hydrogen as a hydrogen source, can implement asymmetric preparation of brivaracetam in a catalytic system with rhodium (I) as a metal center, and has the advantages of mild reaction conditions, simplicity, controllability, high yield, high enantioselectivity, environment friendliness, favorable atom economy, low cost and the like. In addition, the invention also provides the brivaracetam compound prepared by the method.

The invention discloses a method for preparing clioquinol and diiodohydroxyquinoline by a one-pot method, and effectively solves the following problems: (1) the problem that the proportion of isomers in a reaction product is too high due to the fact that hydroxyl is an ortho-/para-positioning group and the purification difficulty is increased when no guiding group exists and C5 halogenation is performed firstly and then C7 iodination is performed is solved; and (2) the problem of low yield (66%) of the first-step C7-site iodination reaction when no guiding group exists and C7 iodination is performed firstly and then C5 halogenation is performed is solved, and the total yield is only about 60% although a C5-site halogenation product can be obtained subsequently. The method effectively overcomes the ubiquitous defects of poor atom economy, harsh reaction conditions, tedious post-treatment steps and the like in the two methods, and is suitable for industrial production. The invention provides an efficient synthesis method for preparing the clioquinol and diiodohydroxyquinoline, and the method has the characteristics of greenness, environmental protection, atom economy, simplicity in operation, easiness in amplification and the like.

The invention discloses a carbon dioxide-based polycarbonate containing an abb structure and a synthesis method thereof, under the action of a difunctional organic boron catalyst, carbon dioxide and alkylene oxide as shown in a formula I are subjected to a copolymerization reaction, the carbon dioxide is used as a structural unit a, the alkylene oxide is subjected to ring opening to serve as a structural unit b to be inserted into a polymer chain, and the carbon dioxide-based polycarbonate containing the abb structure is obtained. Copolymerizing to form carbon dioxide-based polycarbonate containing an abb structure as shown in a formula II; the ab structural unit represents a carbonate unit formed by ring-opening copolymerization of carbon dioxide and one alkylene oxide, the abb structural unit is formed by ring-opening copolymerization of carbon dioxide and two alkylene oxides in sequence, and the bbb structural unit represents an ether unit formed by ring-opening auto-polymerization of alkylene oxides; the molar fraction of the abb structure is 1%-100%. The composition of the polycarbonate can be selectively regulated and controlled by changing one or more reaction conditions such as the catalyst structure, the ratio of the catalyst to the epoxyalkane, the reaction temperature, the carbon dioxide pressure and the reaction time, and the possibility of composition and application of the polycarbonate is widened.

The invention discloses a 2-substituted methylene dihydrobenzo[d]thiazole derivative and a synthesis method thereof. According to the method, an N-alkyl/N-aryl thioamide derivative as shown in a formula (1) is used as a raw material and undergoes intramolecular alkene-thiol interconversion and then further undergoes C-S coupling dehydrogenation coupling reaction in series in an organic solvent inthe presence of an oxidant and a catalyst under mild reaction conditions so as to obtain the 2-substituted methylene dihydrobenzo[d]thiazole derivative. The synthesis method of the 2-substituted methylene dihydrobenzo[d]thiazole derivative has the advantages of mild conditions, economic atomic steps, high yield and the like through condition control, has high chemical selectivity and regioselectivity, and has wide application prospects. The invention also discloses application of the 2-substituted methylene dihydrobenzo[d]thiazole derivative in medicine and material science.

The invention discloses a synthesis method of a 2-hydroxy-indole-3-ketone compound, which comprises the steps of by taking N-(2-acetylphenyl) pyridineamide and a derivative thereof as raw materials, cuprous iodide and other copper salts as catalysts and acetic acid and the like as additives, reacting at the temperature of 80-110 DEG C in an oxygen atmosphere to obtain the 2-hydroxy-indole-3-ketone compound. The method has the characteristics of good substrate applicability, atom economy, easiness in operation, avoidance of substrate preparation, low reagent cost, cost saving, mild reaction conditions, one-step synthesis, high yield and the like, and a new strategy is provided for synthesis of the 2-hydroxy-indole-3-ketone compound.

The invention discloses a method for co-treating electroplating waste residues and chromium-containing heavy metal ion waste liquid. According to the method, the electroplating waste residues of an electroplating factory are used as a mineralizer of a chrome tanning waste liquid of a tanning factory, oxides and hydroxides in the electroplating waste residues adsorb chromium ions and are mineralized and converted into chromium-containing hydrotalcite, the obtained chromium-containing hydrotalcite has an ultra-stable mineralization effect, the chromium ions are not prone to being dissolved out, and secondary pollution cannot be caused. By means of the method, the environmental pollution problem caused by the chrome tanning waste liquid can be effectively solved, recycling of the electroplating waste residues is achieved, the filtered supernate can be used for the follow-up leather pickling procedure, the mineralized solid product can effectively adsorb organic dyes such as Congo red and Evans blue, and the green route of treating waste with waste is achieved. The method is mild in reaction condition, simple and convenient to operate, simple in process, free of alkali, economical in atom, low in cost and capable of being applied to electroplate factories and leather factories on a large scale.

The invention belongs to the technical field of catalysis, and discloses a preparation method of a molybdenum oxide catalyst with a hydrotalcite-like structure and application thereof in the synthesis of methacrylic acid from isobutyraldehyde. Ammonium molybdate, zinc salt and aluminum salt are used as raw materials to prepare the catalyst which has a hydrotalcite-like structure and contains molybdenum oxide, and according to the characteristics of methacrylic acid products, isobutyraldehyde is adsorbed by empty holes in an alumina-zinc oxide carrier to increase the trend of generation of carbonyl carbocations; and by combining the oxygen activation capability of molybdenum oxide and the oxyphilic characteristic of zinc oxide, the adsorbed oxygen is activated into single atoms, then the activated oxygen attacks carbocations, and finally methacrylic acid is generated. According to the method disclosed by the invention, high-selectivity methacrylic acid can be produced by oxidizing isobutyraldehyde in the continuous reactor by utilizing a synergistic effect between components in hydrotalcite and molybdenum oxide. The catalyst prepared by the method is low in cost, high in activity and good in stability, and has a very good industrial prospect.