The invention belongs to the technical field of building material preparation, and particularly relates to a preparation method of a high-strength thermal insulation material. The preparation method comprises the following steps: firstly, grinding and mixing vermiculite and montmorillonite, then putting the obtained mixture into an ethylene glycol solution after the grinding, mixing to prepare a dispersion, dropwise adding an alkali liquor into the dispersion, heating and stirring at high temperature to obtain an alkaline reaction solution, adding ramie into the alkaline reaction solution, carrying out oil bath heating treatment, adding acetic acid, mixing to obtain a to-be-reacted solution, adding ammonium persulfate for reaction, reacting at high temperature and high pressure to obtain aheat treatment product, performing suction filtration on the heat treatment product, washing, performing high-temperature sintering to prepare a modified thermal insulation agent, mixing the modifiedthermal insulation agent, stearic acid and other materials, performing hot pressing, freezing, soaking in acetone, and drying to obtain the high-strength thermal insulation material. The thermal insulation material prepared through the method is good in thermal insulation performance, good in mechanical strength and not prone to deformation and damage and has wide application prospects.