The invention discloses an electronic equipment safe cleaning device. The electronic equipment safe cleaning device comprises a box body, a transport mechanism, an opening-closing mechanism, an air blowing mechanism, a dust collecting and discharging mechanism and monitoring equipment; the opening-closing mechanism, the air blowing mechanism and the monitoring equipment are arranged on the box body in a supported manner, and the dust collecting and discharging mechanism is located at the left end of the box body and communicates with an inner cavity of the box body; the transport mechanism comprises a cross beam, supporting beams, cross beam lifting mechanisms, a walking mechanism, a lifting and rotating mechanism and a clamping mechanism, the cross beam and the supporting beams are slidably connected through the cross beam lifting mechanisms, the walking mechanism and the lifting and rotating mechanism are arranged on the cross beam in a supported manner, and the clamping mechanism is installed at the lower end of the lifting and rotating mechanism. By means of the electronic equipment safe cleaning device, the problems of cleaning, collecting and discharging of dust can be solved, harmless safety protection on working personnel is achieved, and safety of electronic equipment is also protected.