The invention discloses a novel high-temperature alloy heat-resistant stainless steel bolt and a production process thereof. The bolt comprises the components of, by mass, no more than 0.08% of C, no more than 1.00% of Si, no more than 2.00% of Mn, no more than 0.035% of P, no more than 0.030% of S, 24.0-27.0% of Ni, 13.5-16.0% of Cr, 1.90-2.23% of Ti, no more than 0.35% of Al, no more than 0.10-1.50% of Mo, and balance of Fe and unavoidable impurities. The production process comprises that the raw materials are subjected to the steps of solid smelting, cold heading molding, re-crystallization and annealing, stress-removing tempering, hexagon-head cutting and wire rolling, washing, stabilization treatment, and aging treatment. With the process, the bolt has the advantages of high strength, high relaxation-resistance, low notch sensitivity, certain endurance strength, good oxidation resistance, and the like.