The invention proposes a mixed-culture method for macrobrachium nipponense and pseudorasbora parva. The method comprises the following steps: 1) selecting a pond; 2) disinfecting the pond: putting water with a depth of 0.5-1m into the empty pond obtained in the step 1), throwing quick lime for disinfection, planting aquatic plants, hanging a decomposed microbial organic fertilizer at the edge of the pond, placing a shielding substance, and adjusting the water temperature, dissolved oxygen and pH value of the pond to obtain a cultivation pond; 3) throwing young macrobrachium nipponense and fry;and 4) performing breeding management: from a first week to a seventh week, performing feeding for 2 times every day, wherein boiled primary feed is thrown; and after an eighth week, performing feeding according to a water temperature, wherein traditional Chinese medicine feed is thrown, improving the water quality every 3-5 days, and throwing young grass carps and bellamya quadrata. The culturemethod provided by the invention fully utilizes culture resources, maintains the water quality, reduces small trash fishes in the fish pond, enriches the product structure of aquatic animals, reducesthe risk of production, greatly improves the utilization ratio of the feed, and increases the yield of the aquatic animals.