39results about How to "Suitable for a wide range of substrates" patented technology

The invention relates to an asymmetric hydrogenation synthetic method of a chiral aromatic amine compound of iridium-catalyzed imine with high steric hindrance. The catalyst adopted is a catalyst generated by in-situ reaction of a 1, 5-cyclooctadiene iridium chloride dimer and a chiral phosphine-phosphoramidite ligand. The reaction can be carried out under the following condition: the additives comprise iodine, potassium iodide and tetrabutyl ammonium iodide; the temperature is 0-200 DEG C; the solvent is dichloromethane, 1, 2-dichloroethane to the like; the pressure is 10-100 barometric pressures; the time is 12-48 hours; and the proportion of a primer and the catalyst can reach 100000/1. The method provided by the invention has the characteristics of mild reaction condition, high activity, high stereoselectivity, wide application range of the primer and the like.

The invention discloses a synthetic method for preparing allyl indole compounds. A conjugated diene compound represented by formula I, a compound represented by formula II and indole compounds represented by formula III are used as reaction raw materials, an indium catalyst, Ag2CO3 and an organic solvent are added, the reaction raw materials are heated, stirred and reacted under inert gas protection conditions, and post-treatment is carried out after a result of TLC or GC-MS monitoring shows that the reaction is completed in order to obtain the allyl indole compounds represented by formula IV.The method has the advantages of easily obtained sources of the raw materials, simple process route, mild reaction conditions, low process cost, wide substrate adaptation range and high target product yield.

The invention discloses a preparation method of an E-vinyl sulfones compound. The preparation method comprises the following steps: dissolving raw materials of olefin and thiophenol (thioalcohol) into a tetrahydrofuran solvent; then adding lodine pentaoxide and organic base DBU (1,8-diazabicyclo undec-7-ene); directly reacting for 12 to 16 hours under 60 to 80 DEG C; separating and purifying a coarse product after stopping reacting, thus obtaining the E-vinyl sulfones compound. The preparation method has the advantages that raw materials are simple and can be easily obtained, the price is cheap, the reaction requires no metal catalyst, metal pollution is avoided, the operation is simple and is free of harsh conditions of water free, oxygen free and the like, the adaptive range of a substrate is wide, the reaction stereoselectivity is high, the process conditions are stable, and a prepared product is easy to purify.

The invention discloses a synthetic method for a cannabinol compound. The synthetic method comprises the following steps: subjecting two aryl carbon-hydrogen bonds to direct coupling by one step so as to synthesize a 6H-benzo[c]chromene compound with 3,5-dihydroxypentylbenzene as a starting material, palladium acetate as a catalyst and oxygen as an oxidant under the protections of phenolic hydroxyl benzyl and 2-pyridylsulfonyl, and carrying out oxidation, deprotection and methylation so as to synthesize cannabinol with high yield. The method provided by the invention realizes that direct oxidation and aryl coupling through C-H bond activation are used as the key steps of synthesizing the cannabinol, so highly-efficient and simple synthesis of the cannabinol is realized. Compared with a traditional method, the method provided by the invention has the advantages of simple operation, higher reaction yield, environment friendliness and high atom utilization rate.

The invention discloses an effective regioselectivity and diastereoselectivity method. A trans-3, 4-diaryl dihydrocoumarin compound is prepared through [4 + 2] cyclization reaction of alkyne amine and o-hydroxybenzyl alcohol under the condition of non-metal catalysis. Alkyne amine is used as a 2-pi partner and reacts with o-hydroxybenzyl alcohol through the positioning effect of sulfonamide, and various trans-3, 4-diaryl dihydrocoumarin compounds are prepared with good yield and high regioselectivity and diastereoselectivity. The non-metal catalytic reaction method has a wide substrate application range and good functional group tolerance, and can be used for efficiently producing in a gram scale.

The invention a determination method of benzimidazoles drug residue in chicken, chicken liver and chicken kidney. The determination method comprises the step of simultaneously determining residues ofnine benzimidazoles drug residual markers in the chicken, chicken liver and chicken kidney by adopting high-performance liquid chromatography, and the technical blank at this field is filled. A regression equation related coefficient of the method reaches 0.999 and more, the lower determination limit is 50 micrograms/kg, the recovery rates on different adding concentration levels are 75%-110%, andthe relative standard deviation in the experiment is not more than 15%. The technical problem of simultaneously determining nine benzimidazoles drugs is solved, the determination has the originalityon the pre-treatment technology of the sample, especially on the purification technology. The method is scientific and accurate in quantification, strong in interference resistance, wide in matrix adaption range, and capable of satisfying the latest technical requirement of the related supervision department of our country.

The invention discloses a preparation method of a chiral epoxy compound. The preparation method is characterized by preparing the chiral epoxy compound by catalyzing alpha, beta-unsaturated ketone to be subjected to asymmetric epoxidation reaction by adopting a chiral bridging aryloxy alkoxy rare-earth compound as a catalyst; the general formula of the catalyst is [LnL2][{(THF)3Li}2(mu-Cl)], the chemical structural formula of the catalyst is as shown in the specification, wherein Ln is one of rare-earth metals, namely neodymium, samarium, ytterbium, yttrium and lutetium, and L=(S)-2,4-di-tert-butyl-6-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)-phenol. The method disclosed by the invention has the advantages of easiness for catalyst synthesis, convenience for separation and purification, low raw material cost and mildness in reaction condition; the chiral epoxy compound prepared through the method has the advantages of high catalytic activity, good enantioselectivity and wide substrate application range.

The invention discloses a novel method for synthesizing a 2H-azirines derivative. The method comprises the following steps: adding an alkyne compound shown as a formula I and sodium sulfonate shown asa formula II into a Schlenk sealing pipe reactor in sequence; then adding tert-butyl nitrite (t-BuONO) and an organic solvent; heating and stirring to react in an oil bath under a protection condition of an inert atmosphere; after finishing TLC or GC-MS monitoring reaction, carrying out post-treatment to obtain the 2H-azirines derivative shown as a formula III. The method has the advantages of easiness of obtaining raw material sources, simple technological route, moderate reaction conditions, low technological cost, wide substrate applicable range and high yield.

The invention discloses a chiral bridged aryloxyalkyloxy scandium chloride. The chiral bridged aryloxyalkyloxy scandium chloride is characterized in that the chiral bridged aryloxyalkyloxy scandium chloride has a general formula of LScCl(THF), and has a chemical structural formula shown in the specification, and L is (S)-2,4-di-tert-butyl-6-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)-phenolate. The above compound has the advantages of simple synthesis, clear structure and high yield. The invention also provides a preparation method of the compound, and an application method of the compound in the catalysis of the asymmetric hydrogen phosphorization reaction of alpha, beta-unsaturated ketone as a catalyst. The application method has the advantages of mild conditions, high selectivity, good antipodal selectivity and wide substrate adaptation range.

The invention discloses a synthesis method of an ester compound. The method comprises the following steps: carrying out an oxa-Michael addition reaction by using organic carboxylic acid and alpha,beta-unsaturated ketone as initial raw materials and a sodium carbonate aqueous solution as a reaction medium to synthesize the ester compound. Compared with the traditional ester compound synthesis method, the method provided by the invention has the advantages of mild reaction conditions, simple operation, low reagent price, wide substrate application range, environmental friendliness, high yield and complete atom utilization.

The invention discloses a synthetic method of 2-thiophenylbenzoic acid. The synthetic method is characterized by including the steps of: 1) dissolving raw materials, comprising phenylboric acid represented as the formula I and thiosalicylic acid represented as the formula II, in an alkaline solution and adding anhydrous ethylenediamine; 2) in the presence of a metal salt catalyst and a ligand, carrying out a heating reaction at higher than 100 DEG C for more than 16 h with TLC tracing detection, and when then reactant, thiosalicylic acid, disappears, the reaction is determined to be finished; 3) naturally cooling the mixture to room temperature to obtain a mother liquid, extracting the mother liquid with ethyl acetate, drying an organic layer with anhydrous magnesium sulfate, and performing reduced-pressure rotary evaporation to remove the solvent and obtain a solid; and 4) purifying the solid crude product through a silica gel column, collecting an eluent, and performing rotary evaporation to dry the eluent to obtain the 2-thiophenylbenzoic acid represented as the formula III. The method is simple in reaction conditions and high in yield, is easy to enlarge in large scale, and is environment-friendly and low-pollution.