39results about How to "Suitable for a wide range of substrates" patented technology

The invention discloses a reparation method of a sulfonamides compound. The preparation method includes: using thiophenol and amine which are simple and easy to get as raw materials; enabling the raw materials to be in direct oxidation coupling reaction under mediation of safe and stable iodine pentoxide to prepare sulfonamide. The preparation method has the advantages that reaction conditions are mild (60 DEG C), the raw materials are simple and easy to get and low in price, reaction environment is friendly, a substrate is wide in application range, and metal catalysts and harsh reaction conditions like low or high temperature and zero water and zero oxygen are not needed, so that metal pollution related to common synthesis methods is avoided; the preparation method further has the advantages of simple, convenient and safe operation, stable process condition and easiness in product purification and is suitable for large-scale production.

The invention discloses a method for determining the residual amount of benzimidazoles in chicken, chicken liver and chicken kidney. The present invention provides for the first time the simultaneous determination of the residues of nine benzimidazole drug residue markers in chicken, chicken liver and chicken kidney by using high performance liquid chromatography, which fills the technical gap in the art. The correlation coefficient of the regression equation of the present invention reaches more than 0.999, the lower limit of determination is 50 μg / kg, the recovery rate at different concentration levels is 75% to 110%, and the relative standard deviation in the laboratory is ≤15%. The present invention solves the technical problem of simultaneous determination of nine kinds of benzimidazole drugs, and has originality in the sample pretreatment technology, especially in the purification technology. Meet the latest technical requirements of relevant regulatory authorities in my country.

The invention discloses a synthesis method of cannabinoid compounds. The steps are as follows: 3,5-dihydroxypentylbenzene is used as a starting material, protected by a phenolic hydroxybenzyl group, protected by a 2-pyridylsulfonyl group, and palladium acetate is used as a catalyst. Oxygen is used as the oxidizing agent, and two aryl carbon-hydrogen bonds are directly coupled to synthesize 6H-benzo[c]chromene compounds in one step, and then through oxidation, deprotection, and methylation, cannabidiol can be synthesized with high yield. The method of the present invention realizes direct oxidative aryl coupling through C-H bond activation as a key step in the synthesis of cannabinol, and can synthesize cannabinol efficiently and concisely. Compared with traditional methods, it is simple to operate, has higher reaction yield, is environmentally friendly, and has high atom utilization rate.

The invention relates to the field of organic synthesis, and concretely relates to a preparation method of a 5-sulfonyl oxy-8-carboxamidoquinoline derivative, in particular to the method for preparing the 5-sulfonyl oxy-8-carboxamidoquinoline derivative by adopting 8-acetamido quinoline as a raw material. The method is characterized by comprising the steps of adopting trifluoroacetic acid iodobenzene as an oxidizing agent, carrying out C-H functionalization reaction on 8-carboxamidoquinoline and various different N,N'-disulphohydrazide compounds under metal-free catalysis, and obtaining a C5-site sulfonyl oxy substituted product. Compared with the document, the preparation method provided by the invention has the characteristics that the raw materials are easily obtained, the substrate adaption range is wide, the yield is high and the like.

The invention discloses a synthetic method of 2-thiophenylbenzoic acid. The synthetic method is characterized by including the steps of: 1) dissolving raw materials, comprising phenylboric acid represented as the formula I and thiosalicylic acid represented as the formula II, in an alkaline solution and adding anhydrous ethylenediamine; 2) in the presence of a metal salt catalyst and a ligand, carrying out a heating reaction at higher than 100 DEG C for more than 16 h with TLC tracing detection, and when then reactant, thiosalicylic acid, disappears, the reaction is determined to be finished; 3) naturally cooling the mixture to room temperature to obtain a mother liquid, extracting the mother liquid with ethyl acetate, drying an organic layer with anhydrous magnesium sulfate, and performing reduced-pressure rotary evaporation to remove the solvent and obtain a solid; and 4) purifying the solid crude product through a silica gel column, collecting an eluent, and performing rotary evaporation to dry the eluent to obtain the 2-thiophenylbenzoic acid represented as the formula III. The method is simple in reaction conditions and high in yield, is easy to enlarge in large scale, and is environment-friendly and low-pollution.

The invention discloses a β -Aryl- α A synthetic method for naphthol compounds, which uses simple and easy-to-obtain deoxybenzoin compounds and alkyne compounds as raw materials for one-step synthesis β -Aryl- α ‑Naphthols. The method of the present invention realizes the construction of an aromatic ring through domino dehydrogenation, which is simple and efficient β -Aryl- α ‑Naphthol compounds, compared with traditional synthetic methods, the raw materials used are cheap, the operation is simple, the environment is friendly, the yield is high, the substrate adaptability is wider, the complete regioselectivity, and the atom utilization rate are high.

The present invention relates to a kind of preparation method of 4-substituted phenylthioisoquinolin-1(2H)-ketone compound, comprising the following steps: raw material isoquinolin-1(2H)-ketone and diaryl disulfide Dissolve in dichloroethane, then add silver hexafluoroantimonate, react at 60-140°C for 6-12 hours, separate and purify the crude product after the reaction is terminated, and obtain 4-substituted phenylthioisoquinoline-1 (2H )-ketone compounds. The method has the advantages of simple and easy-to-obtain raw materials, simple operation without harsh reaction conditions such as anhydrous and oxygen-free, high yield, high selectivity, wide substrate adaptability, and easy purification of prepared products.

The invention discloses a new method for synthesizing 2H-aziridine derivatives. In the Schlenk sealed tube reactor, add the alkyne compound shown in formula I successively, the sulfonic acid sodium salt shown in formula II, add tert-butyl nitrite (t-BuONO) and organic solvent again, under inert atmosphere protection condition Next, the oil bath was heated and stirred to react, and after the completion of the reaction was monitored by TLC or GC-MS, the 2H-aziridine derivative shown in formula III was obtained through post-processing. The method has the advantages of easy source of raw materials, simple process route, mild reaction conditions, low process cost, wide substrate adaptability and high yield.

The invention discloses a preparation method of a chiral epoxy compound. The preparation method is characterized by preparing the chiral epoxy compound by catalyzing alpha, beta-unsaturated ketone to be subjected to asymmetric epoxidation reaction by adopting a chiral bridging aryloxy alkoxy rare-earth compound as a catalyst; the general formula of the catalyst is [LnL2][{(THF)3Li}2(mu-Cl)], the chemical structural formula of the catalyst is as shown in the specification, wherein Ln is one of rare-earth metals, namely neodymium, samarium, ytterbium, yttrium and lutetium, and L=(S)-2,4-di-tert-butyl-6-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)-phenol. The method disclosed by the invention has the advantages of easiness for catalyst synthesis, convenience for separation and purification, low raw material cost and mildness in reaction condition; the chiral epoxy compound prepared through the method has the advantages of high catalytic activity, good enantioselectivity and wide substrate application range.