39results about How to "Suitable for a wide range of substrates" patented technology

The invention discloses a synthetic method of 2-thiophenylbenzoic acid. The synthetic method is characterized by including the steps of: 1) dissolving raw materials, comprising phenylboric acid represented as the formula I and thiosalicylic acid represented as the formula II, in an alkaline solution and adding anhydrous ethylenediamine; 2) in the presence of a metal salt catalyst and a ligand, carrying out a heating reaction at higher than 100 DEG C for more than 16 h with TLC tracing detection, and when then reactant, thiosalicylic acid, disappears, the reaction is determined to be finished; 3) naturally cooling the mixture to room temperature to obtain a mother liquid, extracting the mother liquid with ethyl acetate, drying an organic layer with anhydrous magnesium sulfate, and performing reduced-pressure rotary evaporation to remove the solvent and obtain a solid; and 4) purifying the solid crude product through a silica gel column, collecting an eluent, and performing rotary evaporation to dry the eluent to obtain the 2-thiophenylbenzoic acid represented as the formula III. The method is simple in reaction conditions and high in yield, is easy to enlarge in large scale, and is environment-friendly and low-pollution.

The invention discloses a β -Aryl- α A synthetic method for naphthol compounds, which uses simple and easy-to-obtain deoxybenzoin compounds and alkyne compounds as raw materials for one-step synthesis β -Aryl- α ‑Naphthols. The method of the present invention realizes the construction of an aromatic ring through domino dehydrogenation, which is simple and efficient β -Aryl- α ‑Naphthol compounds, compared with traditional synthetic methods, the raw materials used are cheap, the operation is simple, the environment is friendly, the yield is high, the substrate adaptability is wider, the complete regioselectivity, and the atom utilization rate are high.

The present invention relates to a kind of preparation method of 4-substituted phenylthioisoquinolin-1(2H)-ketone compound, comprising the following steps: raw material isoquinolin-1(2H)-ketone and diaryl disulfide Dissolve in dichloroethane, then add silver hexafluoroantimonate, react at 60-140°C for 6-12 hours, separate and purify the crude product after the reaction is terminated, and obtain 4-substituted phenylthioisoquinoline-1 (2H )-ketone compounds. The method has the advantages of simple and easy-to-obtain raw materials, simple operation without harsh reaction conditions such as anhydrous and oxygen-free, high yield, high selectivity, wide substrate adaptability, and easy purification of prepared products.

The invention discloses a preparation method of a chiral epoxy compound. The preparation method is characterized by preparing the chiral epoxy compound by catalyzing alpha, beta-unsaturated ketone to be subjected to asymmetric epoxidation reaction by adopting a chiral bridging aryloxy alkoxy rare-earth compound as a catalyst; the general formula of the catalyst is [LnL2][{(THF)3Li}2(mu-Cl)], the chemical structural formula of the catalyst is as shown in the specification, wherein Ln is one of rare-earth metals, namely neodymium, samarium, ytterbium, yttrium and lutetium, and L=(S)-2,4-di-tert-butyl-6-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)-phenol. The method disclosed by the invention has the advantages of easiness for catalyst synthesis, convenience for separation and purification, low raw material cost and mildness in reaction condition; the chiral epoxy compound prepared through the method has the advantages of high catalytic activity, good enantioselectivity and wide substrate application range.