The invention relates to a graphene-organosilicon modified urethane resin synthetic leather, which is prepared from the following ingredients: graphene-organosilicon modified urethane resin, fluorine-modified alkide resin, propylene glycol n-butyl ether, a flatting agent, a thickening agent, a foaming agent, a filler, a water-based color paste, a plasticizer, an ammonium stearate emulsion and de-ionized water, wherein the graphene-organosilicon modified urethane resin is prepared through reaction of polyisocyanate, polyhydric alcohol, a polybasic amine chain extender, oligomer polyhydric alcohol, dimethylolpropionic acid, organosilicon, graphene, a neutralizer and de-ionized water; the synthetic leather prepared by the invention is capable of effectively preventing statical electricity, and has the characteristics of good abrasion resistance, high crosslinking density, good chemical resistance and no pollution.