The invention discloses a processing method for vacuum frozen puffed beef cubes, and belongs to the dry-cure of beef cubes. The method comprises the following steps of: (1) pretreating raw materials, namely, washing fresh beef, cutting the washed fresh beef into meat blocks of 500-1000g, putting the meat blocks into a pot and boiling for 30-40min, fishing out, cutting the boiled meat blocks into beef cubes of 1cm by using a cuber, adding different soup bases with different recipes according to different tastes, boiling, soaking, boiling the soap till being dried, taking out the beef cubes and draining; (2) spreading the drained beef cubes in a single layer, uniformly distributing on material trays, putting the material trays with the beef cubes into an instant freezer, and instantly freezing for 4-6h at minus 40 DEG C so as to ensure that the moisture in the beef cubes is completely frozen; and (3) carrying out vacuum freezing puffing drying by using a vacuum freezing puffing drying machine. By utilizing the method, the original biological activity and the nutrition components of the beef cubes are maintained to the maximum extent, and moreover, the beef cubes have the characteristics of good crispness, completeness in appearance, additive or preservative free, low drying energy consumption, capacities of improving the taste and improving the production efficiency, and the like.