The invention discloses a precipitation-hardened stainless steel for a surgical instrument with excellent corrosion resistance and mechanical performance and a manufacturing method of the precipitation-hardened stainless steel. The indexes of the hardness, the toughness, the corrosion resistance, the mold resistance and the like of the precipitation-hardened stainless steel are all superior to martensitic stainless steel of the same kind. The precipitation-hardened stainless steel comprises the following components of, by weight, 0.005-0.08% of C, less than or equal to 0.05% of N, less than orequal to 1.0% of Si, 0.5-2.5% of Mn, less than or equal to 0.04% of P, less than or equal to 0.01% of S, 11.0-13.0% of Cr, 8.0-10.0% of Ni, greater than or equal to 0.03% and less than or equal to 0.10% of the sum of C and N, 2.0-5.0% of Mo, 1.0-4.0% of Cu, 0.5-2.0% of Ti, 0.15-1.5% of Al, less than or equal to (5*10<-4>)% of the product of Ti and N and the balance unavoidable impurities and Fe.The preparation method comprises the steps that (1) the set components are subjected to alloy smelting by adopting an electric furnace and an external refining mode, so that a steel ingot is formed; (2) the steel ingot is forged to be a steel slab after scalping is conducted, the heating temperature of the forging process is 1050-1250 DEG C, the heating time is 2-5 hours, and the finish forging temperature is 900-980 DEG C; (3) the steel slab is subjected to hot rolling by using a hot rolling machine, so that a hot rolled steel plate or steel belt is prepared, the hot rolling heating temperature is 1000-1200 DEG C, the heat preservation time is 2-5 hours, and the finish rolling temperature is 850-930 DEG C; (4) high-temperature solution treatment is conducted on the steel plate by adoptingsolid solution annealing furnace equipment, the solid solution temperature is 1000-1200 DEG C, the solid solution heat preservation time is 15-30 min, and a cooling mode is water cooling; and (5) aging treatment is conducted on the steel plate which is subjected to solid solution by adopting a heat treatment technology scheme at the temperature of 300-650 DEG C, the aging time is 2-8 hours, and the cooling mode is air cooling after ageing is conducted.