The invention discloses a ginseng, cornua cervi pantotrichum and MACA drug composition and a preparation method thereof and belongs to the technical field of yang-invigorating, body-fortifying and fatigue-resistant traditional Chinese medicines. The ginseng antler and MACA drug composition includes following components, by mass: 10-12 parts of ginseng, 5-6 parts of cornua cervi pantotrichum, 5-6 parts of oil-removed penis et testis cervi, 49-52 parts of MACA, 3-5 parts of atractylodes macrocephala, 3-4 parts of epimedium brevicornu, 3-4 parts of polygala tenuifolia, 2-3 parts of platycladus orientalis seeds, 3-4 parts of cistanche salsa, 2-3 parts of rubus idaeus, 2-3 parts of lycium barbarum, 2-3 parts of ampelopsis japondca, 1-2 parts of cinnamon and 2-3 parts of cnidium monnieri. The ginseng, cornua cervi pantotrichum and MACA drug composition has a yang-invigorating effect and meanwhile has an effect of fortifying and reinforcing body. Because of a compensating and regulating effect and a mutually auxiliary effect among the components, the ginseng, cornua cervi pantotrichum and MACA drug composition is suitable for people whom are suffered from hypertension, hyperlipidemia and hyperglycemia, which is not achieved in conventional yang-invigorating drugs.