The present invention relates to the technical field of drink processing and more particularly relates to alcoholism preventing drink and a preparation method thereof. The alcoholism preventing drink is mainly prepared from 20-25 parts of sugarcanes, 15-20 parts of calendula arvensis herbs, 15-20 parts of celeries, 20-25 parts of radix notoginseng, 15-20 parts of roselle, 5-7 parts of origanum majorana, 10-15 parts of radix puerariae, 5-7 parts of bergamots, 10-15 parts of wax apples, 25-30 parts of mulberries, 25-30 parts of gooseberries, 25-30 parts of hovenia acerba fruits, 7-10 parts of tomatoes, 7-10 parts of watermelons, 7-10 parts of grapes, 5-7 parts of pomegranates, 10-15 parts of cucumis melo var. agrestis fruits, 3-5 parts of honey, etc. The alcoholism preventing drink is prepared by the steps of raw material treating, boiling, centrifuging and filtering, homogenizing, decolorizing, degassing, sterilizing, etc. The alcoholism preventing drink has very good effects of preventing alcoholism, can rapidly prevent alcoholism, alleviates body physical discomfort symptoms caused by drunkenness, protects liver and stomach, helps to quit wine drinking, and is also simple in preparation method and easy to produce.