The invention discloses a transformer core for an inverter power supply, raw material components comprising C, Si, B, (Nb, Sb, V, Mo, Ta, Cr and W), Cu and the balance Fe are put into a vacuum furnace based on a ratio to be refined, the temperature of liquid steel is 1500DEG C, argon is introduced, sprayed and cast on a high rotating speed copper roller, and water is cooled by differential movement, thus obtaining a low magnetostriction amorphous alloy strip with the length of 20-26 micrometers, the strip is wound into a transformer core and heat treatment is carried out at 530DEG C, the temperature is kept for 2-4 hours, thus crystallizing the alloy and obtaining a nano-crystalline core of a low magnetostriction coefficient lambda s; a direct current magnetic field is applied at the same time of keeping and reducing the temperature during the heat treatment; the position of the nano-crystalline core is changed radically, a compressive stress is applied, the stress is eliminated, and the nano-crystalline core recovers until no adhesion exists between lamellas of the whole core; and two side ends of the nano-crystalline core are respectively coated with an unstressed glue layer, and then the surface of the whole nano-crystalline core is coated with an epoxy resin insulating layer for reducing noise. The transformer core which is ideal at present has good noise reduction effect.