65 results about "Bacteriome" patented technology

The invention relates to the field of intelligent regulation and control, and discloses a factory recirculating aquaculture intelligent control method and system fusing multi-source data. The method comprises the following steps: acquiring environmental chemical index data and microbial activity signal data to obtain a comprehensive real-time monitoring data set; if the dynamic change characteristic of the bacterial community structure indicates that the conversion rate is lower than a conversion threshold value, analyzing the coupling influence of an oxygen supply amount index and a nutrient solution proportion index to obtain an optimized adjustment parameter set; adjusting the balance between the nutrient solution dosage index and the buffer agent dosage index, and determining a final regulation and control scheme; according to the stable output value and the adjustment instruction, fusing the dynamic change characteristics of the bacterial community structure, processing real-time feedback circulation, and determining a system stable state index; and updating the bacterial activity model, judging whether the conversion efficiency reaches a target or not, and obtaining an optimized iteration signal. The problems that an existing system is difficult in interactive analysis, low in regulation and control accuracy, weak in data fusion and unstable in conversion efficiency due to state updating lag are solved.

The present application relates to the field of sanitary products, and provides a high-soft skin-friendly sanitary napkin and a preparation method thereof, which solves the problem that the existing sanitary napkin has poor adhesion effect of bacteriostatic components, cannot specifically inhibit harmful bacteria in the vagina, promote the dominant position of beneficial bacteria in the vagina in the bacterial community, does not have the function of releasing bacteriostatic components under specific conditions, cannot have high-efficiency bacteriostasis while reducing the long-time contact of bacteriostatic components with the skin of the vagina, and has a problem of high cytotoxicity; the sanitary napkin comprises, from top to bottom, a surface layer, a flow guide layer, a core body and a leakage-proof bottom film, the surface layer is modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by rolling and drying after immersing pure cotton non-woven fabric in bacteriostatic component microcapsule mixed solution.

The invention discloses a growth-promoting methylobacterium R5018 strain and an application of the growth-promoting methylobacterium R5018 strain. The strain R5018 is obtained by separation from a rice phyllospheric microflora and methanol domestication and screening, and is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC NO: M20252544. The rice growth-promoting microbial inoculum prepared from the strain can be stably colonized at phyllosphere and promote the growth of overground and underground parts of rice through seed soaking, foliage spraying or combined application of the seed soaking and the foliage spraying, and the ear number, the grain number and the yield are remarkably increased. Compared with the prior art, the strain disclosed by the invention is derived from a rice phyllospheric bacterial community, is high in adaptability, environment-friendly and efficient, provides a new microbial technical scheme for high-yield cultivation of rice, and has a wide popularization and application prospect.

Methods for improving the gut microbiota of a subject, increasing one or more bacterial communities belonging to the Helicobacterium or Euglobulaceae families in their colonic flora, for the prevention, treatment, or relief of disease, and for increasing the level of short-chain fatty acids in the colon, comprising administering to the subject a composition containing allulose, erythritol, or a combination thereof. The composition used in the above methods comprises allulose, erythritol, or a combination thereof. The composition comprises allulose, erythritol, or a combination thereof, and one or more colonic bacterial communities from the Helicobacterium or Euglobulaceae families.

A method for detecting anxiety and / or depression metabolic and microbiome markers in a patient with irritable bowel syndrome (IBS) is provided. The method begins with obtaining a serum sample and a fecal sample from the patient. Both samples are processed to extract a gut metagenome, including a bacteriome, a mycobiome, and a virome of the patient, and metabolic features. A classifier is utilized to detect whether a marker set of microbial species and metabolites for depression and anxiety is present in the gut metagenome and the metabolic features.

This invention relates to the field of soil treatment technology, specifically a method and its application for reducing compound fungicides in soil-plant systems by combining nano-silica and nitrification inhibitors. Nitrification inhibitors are used as a nitrogen management measure, and the application of nanomaterials influences soil abiotic properties and bacterial communities to drive the degradation of paclobutrazol and carbendazim. The application of nitrification inhibitors (DCD) produces multiple effects: significantly reducing carbendazim residues in soil-plant systems, paclobutrazol residues in soil, and NO3 in plants. ‑ -N and promote the content of soluble sugars and proline in plants. DCD reduces the activity of the soil electron transport system and β-glucosidase activity, while the addition of nano-SiO2 can mitigate this negative effect. Nano-SiO2 selectively enhances the performance of DCD in reducing compound fungicide residues in pak choi and reducing paclobutrazol residues, but hinders the degradation of carbendazim in pak choi.

The invention relates to the technical field of microbial compositions, in particular to a microbial composition for preventing and treating citrus canker and application of the microbial composition. According to the microbial composition provided by the invention, the pseudomonas Qingdao microbial agent, sodium lignin sulfonate, trehalose, glutathione, ascorbic acid, lecithin and trace elements (Zn, B and Mn) are taken as main raw materials, and the effects of efficiently inhibiting bacteria, remarkably inducing and improving the activity of key defensive enzymes of leaves, promoting synthesis and accumulation of disease-resistant substances and improving the disease resistance of the leaves are achieved through the matching effect of all the components. The diversity and richness of citrus phyllospheric bacterial communities are improved, and the purpose of constructing a stable community dominated by beneficial bacteria is achieved. In other words, the basic stress resistance of the plants can be enhanced, and meanwhile, the growth and metabolism activity of beneficial bacteria is also promoted, so that effective, eco-friendly and sustainable prevention and control of the citrus canker are achieved.

This disclosure provides a method of treating gastrointestinal inflammation such as inflammatory bowel disease (IBS) with a bacteriophage containing composition. The bacteriophage containing composition can be used as prebiotic supplementation and support of the gastrointestinal microflora. This disclosure relates to compositions that comprise one or more types of bacteriophage and methods of using such bacteriophages as a prebiotic to promote the growth of beneficial bacteria by decreasing harmful bacterial populations and releasing nutrients into the environment for good bacteria in the digestive system of an individual.

Provided herein, inter alia, are compositions of organic acid-producing microorganisms and methods of making and using the same to inhibit pathogenic bacterial populations in the gastrointestinal tracts of an animal and additionally promote improvement of one or more metrics in an animal, such as increased bodyweight gain, decreased feed conversion ratio (FCR), improved gut barrier integrity, reduced mortality, reduced pathogen infection, and reduced pathogen shedding in feces.

The present application provides a kind of planting method of reducing allelochemicals and improving polysaccharide content of Rhizoma Polygonati, belongs to plant cultivation technical field.The planting method is planted in acidic sandy loam soil, and "biochar C" is applied to the soil 1-2 times in September-October of the second and third years, and the fruits mature, the stems are laid down after the third year, and then it can be harvested."Biochar C" is a modified, loaded with salicylic acid and UDP-D-galactose biochar.The present application not only helps to improve the physicochemical properties and bacterial community diversity of Rhizoma Polygonati planting soil, thereby reducing the allelochemicals content of Rhizoma Polygonati rhizome, but also can improve the polysaccharide content of rhizome, which helps to improve the quality of Rhizoma Polygonati and enhance its efficacy.

This invention discloses the application of α-bisabolol in the preparation of a quorum sensing quencher for Serratia liquefaction. It belongs to the field of pharmaceutical technology. The purpose of this invention is to provide an application in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction, thereby reducing the toxicity of pathogenic bacteria without inhibiting their growth. This invention provides an application of bisabolol in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction. It offers a novel solution for developing efficient and safe food preservatives.

A method and system for predicting a community dynamic change of a long-period enriched bacterial community in a cold seep. The method includes: collecting Raman spectra of a bacterial culture sample at different enrichment stages, analyzing them using an MCR-ALS algorithm to acquire metabolite data, and storing the metabolite data, environmental parameters, bacterial community α-diversity, and relative abundances of key bacterial taxa jointly as an original dataset; performing importance calculation and data screening on the original dataset using a CART decision tree algorithm; training a random forest prediction model for prediction using the screened dataset; and finally performing community dynamic change prediction using a trained random forest model. According to the present disclosure, a dataset is formed through routine sampling and collection of a complete bacterial community succession process in an early stage of enrichment culture, and an accurate prediction model is constructed by using a machine learning algorithm.

Provided herein are pharmaceutical compositions comprising a bacterial population. The bacterial population comprises one bacterial strains or at least two bacterial strains. Such pharmaceutical compositions can be administered to a subject for prevention and / or treatment of dysbiosis and dysbiosis associated conditions and diseases, such as infant gastrointestinal diseases.

The embodiment of the invention provides a soil bacterial community structure evaluation method and system based on an intermediate infrared spectrum transfer function and application, and relates to the technical field of soil microbial ecology. The method comprises the following steps: S1, collecting a soil sample; s2, acquiring a mid-infrared diffuse reflection spectrum of the soil sample to be detected; s3, acquiring an environment covariant corresponding to the soil sample, wherein the environment covariant comprises at least one of soil physicochemical properties, climate data and topographic parameters; s4, splicing the mid-infrared diffuse reflection spectrum obtained in the step S2 and the environment covariable obtained in the step S3 to form a fusion feature vector as an input feature set; and S5, inputting the input feature set into a pre-trained nonlinear machine learning regression model, and outputting the relative abundance and / or OTU richness of at least one bacteriophage in the soil sample. According to the method, a technical route of combining a mid-infrared (MIR) spectrum and a spectral transfer function (STF) is adopted and is used for predicting the soil bacterial community structure.

A catheter clip-on device applies surface acoustic waves to a catheter for preventing biofilms on the catheter surfaces. Multiple frequencies are generated by at least two PZT elements, coupled to a catheter or in-dwelling device. The relative motion of bacteria results in bacteria quorum sensing, and disrupts the bacteria attachment process.

The application discloses Bacillus tequilensis QingTuHuS40 and application thereof, wherein the Bacillus tequilensis QingTuHuS40 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on January 8, 2025, and the preservation number is CGMCC No. 33325. The Bacillus tequilensis QingTuHuS40 can be planted in rhizosphere of red sand, recruit some other beneficial bacteria, and reshape the bacterial community structure in the rhizosphere of the red sand. Meanwhile, the soil fertility is improved, the degree of soil salinization is improved, the ability of plants to fully utilize environmental nutrients is enhanced, the growth of plants is promoted, and the salt tolerance is enhanced.

The current invention relates to a purified bacterial strain for improving plant growth and / or yield. The invention also relates to a bacterial population, a microbial active ingredient, an agriculturally active ingredient, a synthetic composition, and methods for improving plant growth and / or yield by improving a trait of agronomic importance in a plant and by conferring resistance to a plant pathogen infection.

A system and method for risk assessment of an individual for autism spectrum disorder (ASD) has been provided. The system is using a non-invasive method for risk assessment of the individual, especially children, for ASD through prediction of metabolic potential of the bacteria residing in gastrointestinal tract of the individual. The system is configured to calculate a score, evaluated from the gut bacterial community's taxonomic abundance profile, which is indicative of its metabolic potential for production of a particular neuroactive compound. A set of metabolic pathways harboured by the bacterial community residing in gut has been utilized to develop an ASD diagnosis scheme that, when applied with the conventional screening tests, help in early diagnosis of the ASD. Further, the present disclosure also provides bacterial community based therapeutic approaches that can potentially minimize the side effects through maintaining the healthy cohort of bacteria in gut.

This invention relates to a method for screening environmental microorganisms and antibiotic resistance gene indicators using coupled machine learning, belonging to the field of environmental microbiology and antibiotic resistance monitoring. This method aims to address the technical problem of accurately identifying stable core microbial communities and sensitive resistance gene indicators under seasonal hydrological changes. The technical solution involves: collecting metagenomic data from samples taken during different hydrological periods; analyzing the data to obtain antibiotic resistance genes and bacterial community composition; screening for high-risk resistance genes and core microbial characteristics based on authoritative lists and multi-dimensional criteria; constructing a feature set and performing data preprocessing; establishing a classification prediction model using a random forest algorithm; identifying key biomarkers through feature importance assessment; and validating the model performance using an independent test set. This method effectively improves the ecological relevance and clinical significance of biomarker screening, and enhances the model's ability to discriminate and generalize hydrological changes.

The present application relates to a mildewproof and deodorizing fresh scent type laundry detergent, and belongs to the technical field of detergents.The present application discloses a mildewproof and deodorizing fresh scent type laundry detergent, which comprises the following raw materials in parts by weight: 5-50 parts of a surfactant, 1-3 parts of a thickening agent, 0.5-2 parts of aromatic microcapsules, 0.1-1 parts of a mildewproof and antibacterial agent, 0.5-2 parts of hydrogen peroxide, and 0.5-1 parts of a plant essence.Hydrogen peroxide generates active oxygen to destroy bacteria and has a deodorizing effect;the mildewproof and antibacterial agent denatures protein to achieve a sterilizing effect;and the two agents jointly form a double sterilization effect.The aromatic microcapsules are added with an ethyl acetate extract of hamamelis virginiana, which has antibacterial and bacteriostatic effects.The laundry detergent prepared by the present application has sterilizing and mildewproof effects during a laundry process and after drying, and has a fresh scent.

The invention discloses application of morin, and relates to the technical field of bacterial quorum sensing inhibition. The invention discloses application of morin in preparation of a medicine for reducing enterotoxigenic escherichia coli quorum sensing. Quorum sensing of enterotoxigenic escherichia coli can be reduced by using 5.0 mg / mL of Morrin, so that secretion of virulence factors of the enterotoxigenic escherichia coli is reduced. In the Escherichia coli treated by the Morin, the Morin has no obvious inhibition effect on the growth of the Escherichia coli, and the abundance of an autoinducer 2 (AI-2) and a quorum sensing related gene is obviously reduced, so that the toxicity and the adhesion capability of the Escherichia coli are reduced. The method for reducing enterotoxigenic Escherichia coli quorum sensing provided by the invention is beneficial to replacing traditional antibiotic in-vivo treatment and assists in resisting bacterial infection.

Methods of detecting a target analyte in subsurface soil can providing a bacterial consortium embodying a genetic circuit. Such a consortium can include a sensor bacterium, a signal propagation bacterium, and a display bacterium, which are provided at a soil surface. The sensor bacterium and signal propagation can be allowed to migrate into subsurface soil below the soil surface. The sensor bacterium can be exposed to the target analyte in the subsurface soil. The sensor bacterium can produce a signal molecule in response to the presence of the target analyte. The signal propagation bacterium can amplify the signal molecule by producing additional signal molecules in response to the presence of the signal molecule. The display bacterium can produce an observable signal in response to presence of the signal molecule.

Described herein are compositions, methods, kits and devices for the treatment and / or prevention of a wide spectrum of disease conditions. In particular, bacterial populations described herein are live, purified bacteria for the modulation, restoration, alteration and / or promotion of the microbiome in the respiratory tract of a subject, including the nasal cavity, to promote health. Such bacterial populations may include single or multiple strains for bacteria. The multiple strains of bacteria may be strains from the same or different species, including species of Dolosigranulum pigrum.

The invention discloses a method for detecting spatial bacterial species on a tissue slice. According to the method, a microfluidic device with an orthogonal microchannel array is installed on the surface of a tissue slice on a glass slide, space tag X and Y polynucleotides are loaded respectively, a two-dimensional space coordinate system is formed on a tissue plane, and space coding of bacterial nucleic acid signals is achieved. Sequence information and spatial positioning data of bacterial species can be obtained through reverse transcription, template conversion, PCR amplification and high-throughput sequencing. According to the method, a bacterial 16S rRNA sequence is taken as a detection target, and a streptavidin magnetic bead enrichment and biotin labeling system is combined, so that parallel detection of various bacterial species can be realized. Compared with the traditional FISH and array capture method, the method has the advantages of high detection flux, resolution of about 50 microns, low cost, simplified operation process and the like, and is suitable for research of bacterial community space structures in host tissues and analysis of microbial ecological distribution.

The present application relates to a kind of river planktonic bacteria community composition prediction method based on artificial neural network auto-encoder, belong to environmental science field.The method is by collecting river planktonic bacteria OTU relative abundance and related water environment, meteorological data etc., form original data set, and carry out pre-processing.Using auto-encoder model, the potential space based on OTU composition and the potential space based on environmental elements are constructed by training set, the difference between the two potential spaces is minimized during training, and OTU composition is obtained from potential space by the same decoder.Using SHAP value to explain the model, understand how each environmental factor affects the model prediction of a single sample, and understand the overall impact of environmental factors on model prediction by averaging the SHAP values of multiple samples.The present application explores the change relationship between various environmental factors and river planktonic bacteria relative abundance from the perspective of data-driven deep learning model.

A process for determining the sensitivity or resistance of at least one identified bacterium to at least one antibiotic, wherein the process includes the following steps: a) bringing a sample including bacterium into contact with the at least one antibiotic, the antibiotic inducing the rupture of the bacterial wall and / or of the cytoplasmic membrane and causing the release of the intracellular compounds of the bacterium when the bacterium is termed “sensitive” to the at least one antibiotic, b) incubating the sample with the at least one antibiotic, c) purifying the sample by removing the intact bacteria and the cell debris, d) analyzing the purified sample by mass spectrometry, e) detecting the presence or absence of at least one peak of at least one protein characteristic of the bacterium, and f) determining the sensitivity or the resistance of the bacterial population to the antibiotic.

The invention discloses a prediction model for identifying alcohol use disorder and alcoholic hepatitis and application, a multi-dimensional identification model is constructed by integrating basic clinical information of a patient, intestinal bacterial community characteristics and an intestinal fungal flora structure, and the model is used for identifying alcohol use disorder and alcoholic hepatitis by means of conjoint analysis of intestinal micro-ecological flora (bacteria and fungi) and patient baseline data. A molecular marker combination scheme with innovativeness and practicability is provided for accurate differential diagnosis of AUD and AH.

The application discloses an electrospun composite membrane for slow release of bacterial population response signal molecules and a preparation method and application thereof, and belongs to the field of sewage biological treatment. The application provides an electrospun composite membrane for slow release of bacterial population response signal molecules and a preparation method and application thereof. The composite membrane comprises a base membrane obtained by electrospinning and a functional layer, the functional layer is a fiber with a core-shell structure, the shell layer is a polymer, the core layer is a polymer containing bacterial population response signal molecule material, the base membrane is obtained by uniaxial electrospinning technology, and the functional layer is obtained by uniaxial emulsion electrospinning or coaxial electrospinning technology. The obtained composite membrane has good air permeability, high oxygen transfer rate, large specific surface area and high roughness, which provides favorable conditions for microbial adhesion, and when the composite membrane is used for assembling a flat membrane module and applied to an MABR process, an excellent ammonia nitrogen removal rate can be obtained.

The invention relates to airway medicaments. Described herein are compositions, methods, kits, and devices for treating and / or preventing a wide range of disease conditions. In particular, the bacterial populations described herein are live, purified bacteria for use in modulating, restoring, and / or promoting microbiome in the upper respiratory tract, including the nasal cavity, of a subject to promote health. Such bacterial populations may comprise a single or multiple bacterial strains. The plurality of bacterial strains may be strains from the same or different species, including Corynebacterium and / or Cunglada lazy.