95 results about "Bacteriome" patented technology

A method for improving gut microbiota population in a subject by administering a composition comprising allulose, erythritol or a combination thereof. A method for increasing one or more colonic bacterial populations from the families Lachnospiraceae or Eubacteriaceae by administering a composition comprising allulose, erythritol or a combination thereof. A method for preventing, treating or ameliorating a disease in a subject by administering a composition comprising allulose, erythritol or a combination thereof. The disease may be one or more of metabolic syndrome, obesity, type 2 diabetes, insulin resistance, hyperlipoproteinemia, hyperuricemia, hepatic steatosis, hypercholesterolemia, hypertriglyceridemia, irritable bowel syndrome (IBS), colon cancer, allergy, non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular disease, or inflammation. The bacterial population may be the species Anaerostipes hadrus, Blautia obeum, Anaerobutyricum hallii, Eubacterium rectale (Agathobacter rectalis), Eubacterium callanderi, Eubacterium limosum and Eubacterium maltosivorans. A composition comprising allulose, erythritol or a combination thereof and one or more colonic bacterial populations from the families Lachnospiraceae or Eubacteriaceae is also provided. The composition may in the form of a food composition.

The invention discloses mortierella alpina GRB-1, a fungicide and application of the fungicide, and belongs to the technical field of agricultural microorganisms. The Mortierella alpina GRB-1 is separated from root systems of healthy fruit trees in a continuous cropping apple orchard for the first time, and the Mortierella alpina GRB-1 has the capabilities of producing protease, producing siderophores, dissolving phosphorus, producing ammonia gas and producing auxin, can inhibit fusarium and has the application potential of relieving continuous cropping obstacles. The product prepared by combining the straw with crop straws has an excellent effect on relieving apple continuous cropping obstacles, can promote the growth of overground parts and underground parts of continuous cropping apple trees, improves the relative abundance of bacterial communities in apple continuous cropping soil and the nutrient content in the apple continuous cropping soil, improves the root activity of apples, and improves the survival rate of the apples. The method can be used for preventing and treating apple successive cropping obstacles.

The invention relates to the field of intelligent regulation and control, and discloses a factory recirculating aquaculture intelligent control method and system fusing multi-source data. The method comprises the following steps: acquiring environmental chemical index data and microbial activity signal data to obtain a comprehensive real-time monitoring data set; if the dynamic change characteristic of the bacterial community structure indicates that the conversion rate is lower than a conversion threshold value, analyzing the coupling influence of an oxygen supply amount index and a nutrient solution proportion index to obtain an optimized adjustment parameter set; adjusting the balance between the nutrient solution dosage index and the buffer agent dosage index, and determining a final regulation and control scheme; according to the stable output value and the adjustment instruction, fusing the dynamic change characteristics of the bacterial community structure, processing real-time feedback circulation, and determining a system stable state index; and updating the bacterial activity model, judging whether the conversion efficiency reaches a target or not, and obtaining an optimized iteration signal. The problems that an existing system is difficult in interactive analysis, low in regulation and control accuracy, weak in data fusion and unstable in conversion efficiency due to state updating lag are solved.

This application relates to methods and materials for providing a benefit to a seed or seedling of an agricultural plant (e.g., an agricultural grass plant), or the agricultural plant derived from the seed or seedling. For example, this application provides purified bacterial populations that include novel seed-origin bacterial endophytes, and synthetic combinations of seeds and / or seedlings (e.g., cereal seeds and / or seedlings) with heterologous seed-derived bacterial endophytes.

The invention discloses a rare-earth-based bionic nano material as well as a preparation method and application thereof, and relates to the field of microbial pollution and anti-corrosion treatment. According to the invention, the active center of lactonase can be simulated by using a zinc-based material, and ester bonds in N-acyl homoserine lactone (AHL) molecules can be hydrolyzed by using the lactonase so as to block bacterial quorum sensing (QS) among bacterial florae, so that the antibacterial effect is achieved. Meanwhile, the outer layer of zinc is provided with a cerium element as a shell, so that on one hand, permeation of oxygen, moisture and corrosive ions can be prevented; on the other hand, the structure has hydrophobicity, and corrosion of moisture and salt ions to a metal matrix is further reduced through the hydrophobicity. Cerium and an oxide thereof have certain antibacterial ability and can have a synergistic effect with zinc, Ce can promote generation of Zn-N and generate strong electron interaction, better hydrophobicity is shown, and attachment and growth of microorganisms on the metal surface can be further inhibited.

The present application relates to the field of sanitary products, and provides a high-soft skin-friendly sanitary napkin and a preparation method thereof, which solves the problem that the existing sanitary napkin has poor adhesion effect of bacteriostatic components, cannot specifically inhibit harmful bacteria in the vagina, promote the dominant position of beneficial bacteria in the vagina in the bacterial community, does not have the function of releasing bacteriostatic components under specific conditions, cannot have high-efficiency bacteriostasis while reducing the long-time contact of bacteriostatic components with the skin of the vagina, and has a problem of high cytotoxicity; the sanitary napkin comprises, from top to bottom, a surface layer, a flow guide layer, a core body and a leakage-proof bottom film, the surface layer is modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by rolling and drying after immersing pure cotton non-woven fabric in bacteriostatic component microcapsule mixed solution.

A synthetic microbial community (SynCom) agricultural crop fertilizer composition comprises a microbial stabilizing buffer and bacterial strains configured to mimic the natural diversity of the bacterial community found in the crop phyllosphere microbiome, but at a reduced complexity, yet sufficient to effectively provide increased plant productivity and / or disease protection.

The invention discloses a growth-promoting methylobacterium R5018 strain and an application of the growth-promoting methylobacterium R5018 strain. The strain R5018 is obtained by separation from a rice phyllospheric microflora and methanol domestication and screening, and is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC NO: M20252544. The rice growth-promoting microbial inoculum prepared from the strain can be stably colonized at phyllosphere and promote the growth of overground and underground parts of rice through seed soaking, foliage spraying or combined application of the seed soaking and the foliage spraying, and the ear number, the grain number and the yield are remarkably increased. Compared with the prior art, the strain disclosed by the invention is derived from a rice phyllospheric bacterial community, is high in adaptability, environment-friendly and efficient, provides a new microbial technical scheme for high-yield cultivation of rice, and has a wide popularization and application prospect.

Methods for improving the gut microbiota of a subject, increasing one or more bacterial communities belonging to the Helicobacterium or Euglobulaceae families in their colonic flora, for the prevention, treatment, or relief of disease, and for increasing the level of short-chain fatty acids in the colon, comprising administering to the subject a composition containing allulose, erythritol, or a combination thereof. The composition used in the above methods comprises allulose, erythritol, or a combination thereof. The composition comprises allulose, erythritol, or a combination thereof, and one or more colonic bacterial communities from the Helicobacterium or Euglobulaceae families.

A method for detecting anxiety and / or depression metabolic and microbiome markers in a patient with irritable bowel syndrome (IBS) is provided. The method begins with obtaining a serum sample and a fecal sample from the patient. Both samples are processed to extract a gut metagenome, including a bacteriome, a mycobiome, and a virome of the patient, and metabolic features. A classifier is utilized to detect whether a marker set of microbial species and metabolites for depression and anxiety is present in the gut metagenome and the metabolic features.

This invention relates to the field of soil treatment technology, specifically a method and its application for reducing compound fungicides in soil-plant systems by combining nano-silica and nitrification inhibitors. Nitrification inhibitors are used as a nitrogen management measure, and the application of nanomaterials influences soil abiotic properties and bacterial communities to drive the degradation of paclobutrazol and carbendazim. The application of nitrification inhibitors (DCD) produces multiple effects: significantly reducing carbendazim residues in soil-plant systems, paclobutrazol residues in soil, and NO3 in plants. ‑ -N and promote the content of soluble sugars and proline in plants. DCD reduces the activity of the soil electron transport system and β-glucosidase activity, while the addition of nano-SiO2 can mitigate this negative effect. Nano-SiO2 selectively enhances the performance of DCD in reducing compound fungicide residues in pak choi and reducing paclobutrazol residues, but hinders the degradation of carbendazim in pak choi.

The invention relates to the technical field of microbial compositions, in particular to a microbial composition for preventing and treating citrus canker and application of the microbial composition. According to the microbial composition provided by the invention, the pseudomonas Qingdao microbial agent, sodium lignin sulfonate, trehalose, glutathione, ascorbic acid, lecithin and trace elements (Zn, B and Mn) are taken as main raw materials, and the effects of efficiently inhibiting bacteria, remarkably inducing and improving the activity of key defensive enzymes of leaves, promoting synthesis and accumulation of disease-resistant substances and improving the disease resistance of the leaves are achieved through the matching effect of all the components. The diversity and richness of citrus phyllospheric bacterial communities are improved, and the purpose of constructing a stable community dominated by beneficial bacteria is achieved. In other words, the basic stress resistance of the plants can be enhanced, and meanwhile, the growth and metabolism activity of beneficial bacteria is also promoted, so that effective, eco-friendly and sustainable prevention and control of the citrus canker are achieved.

This disclosure provides a method of treating gastrointestinal inflammation such as inflammatory bowel disease (IBS) with a bacteriophage containing composition. The bacteriophage containing composition can be used as prebiotic supplementation and support of the gastrointestinal microflora. This disclosure relates to compositions that comprise one or more types of bacteriophage and methods of using such bacteriophages as a prebiotic to promote the growth of beneficial bacteria by decreasing harmful bacterial populations and releasing nutrients into the environment for good bacteria in the digestive system of an individual.

Provided herein, inter alia, are compositions of organic acid-producing microorganisms and methods of making and using the same to inhibit pathogenic bacterial populations in the gastrointestinal tracts of an animal and additionally promote improvement of one or more metrics in an animal, such as increased bodyweight gain, decreased feed conversion ratio (FCR), improved gut barrier integrity, reduced mortality, reduced pathogen infection, and reduced pathogen shedding in feces.

The present application provides a kind of planting method of reducing allelochemicals and improving polysaccharide content of Rhizoma Polygonati, belongs to plant cultivation technical field.The planting method is planted in acidic sandy loam soil, and "biochar C" is applied to the soil 1-2 times in September-October of the second and third years, and the fruits mature, the stems are laid down after the third year, and then it can be harvested."Biochar C" is a modified, loaded with salicylic acid and UDP-D-galactose biochar.The present application not only helps to improve the physicochemical properties and bacterial community diversity of Rhizoma Polygonati planting soil, thereby reducing the allelochemicals content of Rhizoma Polygonati rhizome, but also can improve the polysaccharide content of rhizome, which helps to improve the quality of Rhizoma Polygonati and enhance its efficacy.

The present invention relates to the preparation and use of high-entropy nanozymes with multi-pathway synergistic antibacterial effects, belonging to the field of nanozyme catalytic materials. The present invention, for the first time, utilizes a hydrothermal method and high-temperature calcination method to synthesize oxygen-vacancy-rich high-entropy oxides with haloperoxidase-like, peroxidase-like, and glutathione oxidase-like activities. These oxides can catalyze bromide ions and hydrogen peroxide to generate hypobromous acid, which interferes with bacterial quorum sensing, and hydroxyl radicals, which disrupt structure and function. Furthermore, these oxides consume glutathione, which maintains the internal redox balance of bacteria. This allows for multi-pathway synergistic and efficient bacterial damage and inactivation, helping to address the problems of existing antifouling nanozyme materials, which suffer from a single catalytic pathway and poor component adjustability. This allows for the practical expansion of high-entropy nanozyme coatings, and has potential application prospects in the field of marine biofouling.

A lysogenic phage community, its extraction method and application. The tangential flow technology is used to proportionally isolate bacteria and phage communities from in-situ soil, and single-bacteria communities and single-phage communities are obtained through enrichment and concentration. At the same time, mitomycin C is added to the single-bacteria community for lysogenic induction, and then the tangential flow system is used again for filtration and enrichment to obtain a high-throughput lysogenic phage community. Finally, we obtain single-bacteria communities, bacteria-phage mixed communities, and bacteria-lysogenic phage mixed communities. The phage transplantation technology can promote the participation of indigenous microorganisms in the process of promoting plant growth and development. The transplanted lysogenic phages can participate in the synthesis and metabolism of host plant hormones by optimizing the microbial network structure and injecting auxiliary metabolic genes. This method provides a long-term and environmentally friendly microbial synergistic growth promotion technology for the development of green agriculture in China.

The invention features E. faecalis phage-derived antimicrobial agent (efagins). The invention also features compositions and methods of using the efagins to treat bacterial infections.

The present invention belongs to the technical field of the restoration of coal mine restoration areas. In order to understand the effects of heavy metals and PAHs on the diversity of restored plants and soil microbial communities under different utilization modes, a method for constructing a combined plant-microbial community restoration system in coal mine restoration areas is provided. The quadrat survey method is used to investigate the composition and structural characteristics of the vegetation community in the gangue restoration area; the Miseq high-throughput sequencing technology is used to detect the composition and diversity of the bacterial community in the soil of the gangue area, analyze the composition, distribution and diversity characteristics of the microbial community at different stages of mining area accumulation and restoration and in different seasons of the restoration area, and analyze their differences, and use the co-evolution strategy to screen the plant rhizosphere-microbial ecological community that can efficiently degrade pollutants; construct a soil-plant-microbial efficient degradation system. The plants that can enrich heavy metals and have a strong nitrogen fixation effect are screened out, and the dominant bacterial genera that are tolerant to heavy metals or can degrade PAHs are found, which helps the further restoration of the gangue mountain in this area.

An anaerobic chamber system to evaluate human enteric disease is described herein that can be used to test therapeutic components. In specific embodiments, the anaerobic chamber is used to determine the effect of one or more bacterial communities on ex vivo enteroid cultures. In one application, the anaerobic chamber system is used to determine the efficacy of therapeutic components in ameliorating human enteric disease using personalized medicine.

This invention discloses the application of α-bisabolol in the preparation of a quorum sensing quencher for Serratia liquefaction. It belongs to the field of pharmaceutical technology. The purpose of this invention is to provide an application in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction, thereby reducing the toxicity of pathogenic bacteria without inhibiting their growth. This invention provides an application of bisabolol in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction. It offers a novel solution for developing efficient and safe food preservatives.

The present invention discloses a strain of Mortierella alpina GRB-1, a microbial agent and its application, belonging to the field of agricultural microbiology. The present invention is the first to isolate a strain of Mortierella alpina ( Alpine Mortierella ) GRB‑1, a strain that simultaneously produces proteases, siderophores, phosphate solubilization, ammonia, and auxin, can inhibit Fusarium spores and has the potential to alleviate continuous cropping problems. Combining it with crop straw to create a product has shown excellent results in alleviating continuous cropping problems with apples. It can promote the growth of both above- and below-ground parts of continuously cropped apple trees, increase the relative abundance of bacterial communities and nutrient content in soils containing continuously cropped apples, and enhance apple root vitality, making it suitable for preventing and treating continuous cropping problems.

A method and system for predicting a community dynamic change of a long-period enriched bacterial community in a cold seep. The method includes: collecting Raman spectra of a bacterial culture sample at different enrichment stages, analyzing them using an MCR-ALS algorithm to acquire metabolite data, and storing the metabolite data, environmental parameters, bacterial community α-diversity, and relative abundances of key bacterial taxa jointly as an original dataset; performing importance calculation and data screening on the original dataset using a CART decision tree algorithm; training a random forest prediction model for prediction using the screened dataset; and finally performing community dynamic change prediction using a trained random forest model. According to the present disclosure, a dataset is formed through routine sampling and collection of a complete bacterial community succession process in an early stage of enrichment culture, and an accurate prediction model is constructed by using a machine learning algorithm.

The invention provides an application of sponge iron synergistic compound bacteria in cow dung aerobic composting, and belongs to the technical field of cow dung composting. According to the application of the sponge iron synergistic compound bacteria in aerobic composting of cow dung, the compound bacteria comprise bacillus subtillis and lysinibacillus fusiformis. The sponge iron and the compound bacteria are added into the cow dung aerobic compost, so that the compost temperature can be increased, and the compost process is accelerated; the degradation of organic matters can be promoted and the humification degree of compost can be improved. In addition, the microbial community structure can be optimized, and the diversity and richness of bacterial communities in the composting process are remarkably improved.

Provided herein are pharmaceutical compositions comprising a bacterial population. The bacterial population comprises one bacterial strains or at least two bacterial strains. Such pharmaceutical compositions can be administered to a subject for prevention and / or treatment of dysbiosis and dysbiosis associated conditions and diseases, such as infant gastrointestinal diseases.

The embodiment of the invention provides a soil bacterial community structure evaluation method and system based on an intermediate infrared spectrum transfer function and application, and relates to the technical field of soil microbial ecology. The method comprises the following steps: S1, collecting a soil sample; s2, acquiring a mid-infrared diffuse reflection spectrum of the soil sample to be detected; s3, acquiring an environment covariant corresponding to the soil sample, wherein the environment covariant comprises at least one of soil physicochemical properties, climate data and topographic parameters; s4, splicing the mid-infrared diffuse reflection spectrum obtained in the step S2 and the environment covariable obtained in the step S3 to form a fusion feature vector as an input feature set; and S5, inputting the input feature set into a pre-trained nonlinear machine learning regression model, and outputting the relative abundance and / or OTU richness of at least one bacteriophage in the soil sample. According to the method, a technical route of combining a mid-infrared (MIR) spectrum and a spectral transfer function (STF) is adopted and is used for predicting the soil bacterial community structure.

A catheter clip-on device applies surface acoustic waves to a catheter for preventing biofilms on the catheter surfaces. Multiple frequencies are generated by at least two PZT elements, coupled to a catheter or in-dwelling device. The relative motion of bacteria results in bacteria quorum sensing, and disrupts the bacteria attachment process.

The invention discloses a deep sea mining area bacteria monitoring data analysis method, which comprises: collecting a deep sea environment DNA sample, carrying out PCR amplification on a 16S rRNA V3-V4 region by using a specific primer, obtaining sequence data through high-throughput sequencing, carrying out quality control, sequence splicing and non-microorganism removal on the sequence data, and carrying out quantitative analysis on the sequence data. And merging according to 100% sequence similarity to generate environmental DNA abundance data and environmental DNA sequence data. And the de-noised abundance data and the sequence data subjected to exclusion, mapping, normalization and Fourier transform are used as input to be sent into a multi-mode variational inference model to implement dimension reduction. And finally, carrying out classification annotation and diversity analysis on the flora by utilizing dimension reduction data. According to the method, the composition and diversity change of the bacterial community in the deep sea mining area can be accurately revealed, and a flexible and reliable technical platform is provided for ecological monitoring of the deep sea mining area and evaluation of the influence possibly caused by exploration and development of mineral resources on the marine environment.

The application discloses Bacillus tequilensis QingTuHuS40 and application thereof, wherein the Bacillus tequilensis QingTuHuS40 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on January 8, 2025, and the preservation number is CGMCC No. 33325. The Bacillus tequilensis QingTuHuS40 can be planted in rhizosphere of red sand, recruit some other beneficial bacteria, and reshape the bacterial community structure in the rhizosphere of the red sand. Meanwhile, the soil fertility is improved, the degree of soil salinization is improved, the ability of plants to fully utilize environmental nutrients is enhanced, the growth of plants is promoted, and the salt tolerance is enhanced.

The current invention relates to a purified bacterial strain for improving plant growth and / or yield. The invention also relates to a bacterial population, a microbial active ingredient, an agriculturally active ingredient, a synthetic composition, and methods for improving plant growth and / or yield by improving a trait of agronomic importance in a plant and by conferring resistance to a plant pathogen infection.