The invention relates to a straw biology organic fertilizer and the manufacture method that could effectively solves the fully use of straw, fertilizing, and good harvest problem. The method is mixing straw powder, dejection, shale powder, fused calcium magnesium phosphate, mixed cake, bran powder, urea, and other assistant material and compounding enzyme nutrient solution. The method is that adding dejection, shale powder, fused calcium magnesium phosphate, mixed cake, bran powder, urea, and assistant material to the smashed straw, mixing with enzyme nutrient solution taking fermenting, deodorizing, detoxicating, graining, drying, filtering, and packaging. The invention has good effect, easy method, plenty resource, wide application, and has great prospect.