8 results about "Copper pyrithione" patented technology

A use of a pyrithione derivative in the treatment of colorectal cancer demonstrates an affinity of zinc pyrithione (ZPT), copper pyrithione (CPT) and monomeric copper pyrithione (monomeric CPT) for epigenetic modifying enzyme HSPBAP1, wherein the pyrithione derivative can effectively target the HSPBAP1 protein; moreover, in vitro migration and invasion assays were performed on various colorectal cancer cell lines, revealing that ZPT, CPT, and monomeric CPT significantly inhibit in vitro migratory and invasive capabilities of various colorectal cancer cells, thereby indicating that the pyrithione derivative has broad anti-metastatic capabilities against colorectal cancer.

The invention relates to the technical field of functional antibacterial coatings, in particular to a modified nano silicon dioxide reinforced fluorocarbon resin antibacterial coating as well as a preparation method and application thereof. The coating has efficient antibacterial performance on standard strains and drug-resistant strains (such as aspergillus niger). According to the material, copper pyrithione and vinyl fluoride-vinyl ether resin form a fusion system, modified nano silicon dioxide inorganic particles are further introduced, the composite antibacterial coating is formed, the water resistance of a coating is remarkably improved, and meanwhile the excellent antibacterial performance is kept. The coating is particularly suitable for long-term protection of wood surfaces in (ancient) buildings and gardens, and an efficient and low-concentration novel solution is provided for solving the problems that a traditional coating is poor in antibacterial property, insufficient in drug-resistant bacterium resistance and the like. The composite antibacterial coating also provides more efficient and stable protection for wood exposed in the environment for a long time, has a wide application prospect, and can be used in multiple fields of building, garden, cultural heritage protection and the like.

The application provides a use of pyrithione derivatives in colorectal cancer treatment, and belongs to the technical field of biological medicines.The application provides pyrithione derivatives, and especially verifies the affinity of zinc pyrithione (ZPT), copper pyrithione (CPT) and copper pyrithione monomer (CPT monomer) with an epigenetic modification enzyme HSPBAP1, and the pyrithione derivatives can effectively target the HSPBAP1 protein; meanwhile, the in-vitro migration and invasion abilities of various colorectal cancer cell lines are determined, and it is found that ZPT, CPT and CPT monomer can significantly inhibit the in-vitro migration and invasion abilities of various colorectal cancer cells, which indicates that the pyrithione derivatives have a wide anti-tumor metastasis ability for colorectal cancer.

The present invention provides an antifouling paint composition capable of forming an antifouling coating film which is excellent in both general standing antifouling property and standing antifouling property after long-term dynamic immersion, and is also excellent in adhesion and peeling resistance to a base coating film and a middle coating film, and in adhesion to an old antifouling coating film. The antifouling paint composition of the present invention contains a hydrolyzable polymer (A) containing a metal ester group, which contains a structural unit derived from a metal ester group-containing monomer (a1) represented by the following formula (1) and / or a structural unit derived from a metal ester group-containing monomer (a2) represented by the following formula (2), metomidine (B), bromopyrollitryl cyanide (C), copper pyrithione (D), and a linear or branched alkyl carboxylic acid (E) having 4 to 30 carbon atoms. In formula (1), R 11 each independently represents a monovalent group containing a terminal olefinic unsaturated group, and M represents a copper atom or a zinc atom. In formula (2), R 21 represents a monovalent group containing a terminal olefinic unsaturated group, and R 22 represents a monovalent organic group having 1 to 30 carbon atoms which does not contain a terminal olefinic unsaturated group, and M represents a copper atom or a zinc atom.

The application relates to the technical field of marine paint, and particularly discloses a self-polishing antifouling paint and a preparation method thereof. The self-polishing antifouling paint comprises, by weight, 100 parts of capsaicin modified acrylic resin, 40-50 parts of rosin, 10-25 parts of chlorinated paraffin, 25-30 parts of dimethylbenzene, 110-150 parts of cuprous oxide, 35-50 parts of zinc oxide, 17-35 parts of copper pyrithione, 10-20 parts of talcum powder, 15-30 parts of red iron oxide and 10-15 parts of a dispersing agent. The self-polishing antifouling paint adopts the capsaicin modified acrylic resin as a base resin, the resin not only retains the excellent effect of capsaicin as an antifouling agent, reduces the use amount of cuprous oxide, but also greatly reduces the irritability of capsaicin in the production process.

The utility model discloses a kind of for pyrithione copper drying device, belong to pyrithione copper production technical field, including drying chamber, drying chamber outer wall is equipped with heating jacket, vertical rotating shaft is equipped in drying chamber, first annular plate, second annular plate are sequentially equipped from top to bottom in drying chamber, first annular plate outer edge is connected with drying chamber inner wall, central discharge port is left between first annular plate and rotating shaft, second annular plate inner edge is rotatably connected with rotating shaft, side discharge port is left between second annular plate and drying chamber inner wall;First annular plate top and second annular plate top are each equipped with a plurality of harrow arm, harrow arm one end is fixedly connected with rotating shaft, a plurality of harrow teeth are equipped at harrow arm bottom, a plurality of stirring rods are also equipped on rotating shaft, stirring rod is located below second annular plate.The utility model material is preheated on annular plate, harrow tooth makes it overturn, material is uniformly preheated;Stirring rod stirs the material at the bottom of drying chamber, sufficiently dries it, reduces drying time.

The present application relates to the technical field of lubricating grease, and provides an anti-marine organism lubricating grease, a preparation method and application thereof.The anti-marine organism lubricating grease comprises the following components in mass percentage: base oil 47-88%, composite aluminum base thickening agent 5-10%, adhesion agent 0.5-2%, antioxidant 0.5-3%, extreme pressure anti-wear agent 5.0-30%, antirust agent 0.5-3%, and marine organism inhibitor 0.5%-5%; wherein the marine organism inhibitor is one or more of cuprous oxide, copper pyrithione and copper pyrrolidine dithiocarbamate.The present application improves the anti-marine organism performance of the lubricating grease without changing the physical and chemical properties of the lubricating grease itself, and the obtained lubricating grease has the characteristics of anti-marine organism, seawater resistance, extreme pressure and anti-wear, and can meet the lubrication and protection requirements of the related parts of the water surface and underwater ship in the marine environment, and has a wide application prospect.

Pyrithione derivatives are used in the treatment of colorectal cancer, belonging to the field of biopharmaceutical technology. The affinity of zinc pyrithione (ZPT), copper pyrithione (CPT), and copper pyrithione monomers (CPT monomers) toward the epigenetic modification enzyme HSPBAP1 is verified, wherein the pyrithione derivatives can effectively target the HSPBAP1 protein. Moreover, in vitro migration and invasion assays are also performed on various colorectal cancer cell lines. It is found that ZPT, CPT, and CPT monomers can significantly inhibit the migration and invasion of various colorectal cancer cells in vitro, demonstrating that the pyrithione derivatives have broad-spectrum anti-metastatic capabilities against colorectal cancer.