The invention discloses a method for preparing a maize biology base special-leather-feel leisure shell fabric. The method comprises the following steps of: (1) selecting raw materials; (2) performing variant compounding; (3) weaving; and (4) dyeing and performing post finishing. By adopting the method, the shell fabric has the advantages of smooth surface, flexible hand feel, high texture, water resistance, stain resistance, antistatic property, superior wrinkle resistance, luster and texture of a natural leather material, high air permeability, high moisture permeability, freeness from ironing, easiness for maintenance and the like, can be used for making autumn and winter clothes such as dust coats, jacks, cotton dresses and the like as well as spring and summer clothes such as unlined business suits, slack business suits, unlined jacks and the like, and can be washed with water or in a dry way.