The invention discloses a cyclone reburning method and device for reburning fuel in a cyclone drum for denitration. The device comprises a cyclone drum, a boiler main hearth and a granulating water tank, wherein the cyclone drum and the boiler main hearth are connected seamlessly through a concave outlet of the cyclone drum, overfire air nozzles are distributed at the upper part of the boiler main hearth, and the granulating water tank used for granulating liquid slag is arranged at the bottom of the boiler main hearth. In the invention, since reburning denitration is realized in the cyclone drum, reburnt fuel can stay in a boiler for a longer time; meanwhile, the upper part of the boiler main hearth at the rear part of the boiler has enough space for the distribution of the overfire air nozzles; therefore, the problem that the normal operation of a cyclone furnace boiler is threatened when a conventional reburning technology is adopted is solved very well, and the problems of the reburning technology per se, such as low burn-off rate of reburnt fuel and high smoke temperature of a hearth outlet and the like, can be overcome very well. The method disclosed in the invention not only has high denitration rate, but also uses simple equipment, is convenient and easy to implement, has low cost, is easy in the reformation of a traditional boiler, has remarkable social benefit and can be promoted and applied widely.