The invention discloses heparin sodium production equipment based on a secondary enzymolysis method. The heparin sodium production equipment comprises a cylinder body, supporting legs, a stirring device, a cover plate, a first rotating piece and a detection structure, the stirring device comprises a stirring cavity formed in the cylinder body, a first cavity formed in the inner wall of the cylinder body, a heating pipe arranged in the first cavity, a motor arranged on the cover plate, a telescopic stirring structure arranged below the cover plate, and a first auxiliary structure arranged on the side wall of the stirring cavity; the device also comprises a discharging structure arranged at the bottom of the stirring cavity; through the arrangement of the telescopic stirring structure, a stirring shaft can be contracted after stirring is completed, and the stirring shaft is opened in the form of a flip cover, so that the design height of a tank body is higher, an occupied area is reduced, accommodating volume of equipment is increased, and the interior of the equipment is more convenient to clean; Heating efficiency is effectively guaranteed in a side wall heating mode, internal temperature balance is guaranteed, and preparation efficiency is improved.