31results about How to "Save research money" patented technology

The invention discloses a new drug against lung cancer and an extraction separation method of the new drug. The extraction separation method comprises the following steps of: performing homogenate, 70% alcohol extraction, deproteinization by trichloroacetic acid and vacuum freeze-drying on whole mollusk Vaginulus alteFerussac, performing chromatographic separation by gel columns repeatedly for multiple times, detecting molecular weight, molecular organization and primary molecular structures of the components, and conducting in-vivo and vitro anticancer pharmacology experiments to obtain an anti-lung-cancer active ingredient JK of the Vaginulus alteFerussac. Animal experiments prove that the heavy inhibition ratio of the JK on human-derived lung adenocarcinoma A549 cytoma reaches 54.37%; the heavy inhibition ratio of the JK on human-derived small cell lung cancer CNI-H446 cytoma reaches 59.73%; the heavy inhibition ratio of the JK on rat-derived Lewis lung cancer tumor reaches 49.49%; and the combination of the JK and cinobufotalin generates a synergistic effect. The experiments also prove that the JK has anticancer mechanisms shared by multiple Chinese traditional medicines, is compound with multiple target points, and relates to the synthesis of nucleic acid for inhibiting lung cancer cells, induction of lung cancer apoptosis, angiogenesis for restraining lung cancer tissue and the adhesion of the cancer cells on a vascular wall after the cancer cells invade blood circulation.

The invention discloses a method for simulating a verisimilar target echo, belonging to the field of electronic simulation. A plane wave database concept is derived from a multi-level subalgorithm of electromagnetic calculation, i.e. a scattered field of a target under incident wave excitation in any direction can be described by k plane waves, wherein k is related to the electrical size of the target. The invention expands the plane wave database concept, indicates K*K plane waves of the target under the excitation of an incident field in k directions according to a reciprocity principle and can accurately describe the scattered field generated by the excitation of the target in any incident direction and form a perfect broadband plane wave database N*K*K by N K*K databases under N different frequencies; and the scattered field of the target in any incident direction and frequency can be directly read by the broadband plane wave database or obtained through interpolation. The invention realizes the real-time simulation of the verisimilar target echo and can serve multiple radar application technologies, such as radar imaging, image features, target property, target identification, figuration design, and the like.

The invention discloses a bridgehead settlement compensation amount test device and method. The device comprises a pressurization unit, a model case and a control system. The pressurization unit comprises a frame, an oil cylinder, a pressure head and a guiding mechanism. The frame has a U-shaped structure and comprises a first support leg, a second support leg and a crossbeam. The oil cylinder is arranged in the middle of the crossbeam, the cylinder body of the oil cylinder is fixedly connected to the crossbeam, the end of a piston rod is provided with the pressure head and the guiding mechanism is arranged between the pressure head and the frame. The model case comprises a case body, a roadbed pavement model, a displacement sensor and several steel pipes. The roadbed pavement model is arranged in the case body. The upper part of the case body is provided with the displacement sensor. The several steel pipes go through the case body and are connected to the case body. The steel pipes are provided with water leakage apertures. Through simulation of different pavement structures, a relationship of a swelling amount increasing rule, compensation layer position, thickness, lateral confinement and compaction rate, and a lime slurry injection amount is researched and the relationship lays the foundation of design index formation.

The invention aims to establish an efficient, fast and reliable screening method of TTR (transthyretin) small-molecule inhibitors, overcomes the defects of the prior art and is applicable to design of medicines for amyloidosis caused by TTR fibrosis. A small-molecule database is screened and predicted by means of 3D-QSAR (3-dimensional quantitative structure activity relationship), molecular docking, pharmacophore models and the like; small molecules capable of serving as lead compounds are determined preliminarily; further cell screening is performed. The screening method is fast and efficient; a plurality of drug screening and design methods based on receptors and ligands are applied; accordingly, reliability of screening results is improved greatly. Cell levels are subjected to biological screening by lead compounds obtained by screening, so that screening speed is higher and development and search cycle of novel inhibitors is shortened.

The invention provides a method and device used for monitoring and predicting scales in a combustor. The method comprises steps of by acquiring one kind of or various kinds of combustion signals of the combustor and/or a gas system corresponding to the combustor; determining combustor performance models corresponding to the combustion state signals according to the combustion signals; acquiring acombustor performance reference model corresponding to the combustor; and finally, according to the combustor performance model, by combining the combustor performance reference model, determining early warning information corresponding to the combustor. Thus, the generated combustor performance model is quite practical; by use of the method and the device, large quantity of research funds and usecost can be reduced; the scales and the development trend of the combustor can be monitored and predicted in a quite simple and convenient mode; and the method and the device can be used for strategyplanning of maintenance of economical combustors or gas turbines.

The invention discloses a method for observing the water level of multilayer underground water. The method comprises the following steps: S1, punching; S2, preparing a pipe; S3, observing a water level; S4, transmitting signals; S5, receiving the signals; S6, arranging data. A visual observation method is adopted, the water pump is used for pumping underground water at different heights for observation, and the height of the underground water level is visually observed. Equipment used in the method is ingenious, the equipment is not easy to damage, manufacturing cost is low, the underground water level observation device is durable in use, a large amount of equipment funds can be saved, popularization and installation of the water level observation device are facilitated, and scientific research funds are saved. The method can observe the underground water level in a circulating mode, cannot damage the underground water level, protects ecology, can observe the underground water level for a long time, collects data, and lays a data foundation for other hydrological scientific researches.

The invention belongs to the technical field of drug activity prediction methods, and relates to a method for predicting the inhibitory activity of a fructose-1, 6-diphosphatase inhibitor based on a quantitative structure-activity relationship model. The method comprises the specific steps of collection of a sample set, processing and optimization of the sample set, establishment of an inhibitor molecule descriptor set, data set division, establishment of a QSAR linear model through a heuristic algorithm, establishment of a QSAR nonlinear model through a gradient boosting regression algorithm, and comparative analysis of two model results. In the initial development stage of the inhibitor, the molecular structure of the inhibitor is input through a computer, the inhibition concentration of the inhibitor is predicted based on HM and GBR methods, results of the two models are compared to solve the problem that prediction precision of a single linear model is not enough, the development risk of the inhibitor in the later stage is effectively reduced, and the research and development cost is reduced; the two established models are verified, so that the reliability of the models is proved; and meanwhile, a pioneer is created for application of the GBR algorithm in the field of computer-aided drug design.

The invention discloses a method for measuring multiple parameters of retina of a living mouse. The method comprises the following steps: fixing a mouse, which is successfully anesthetized, on a three-dimensional experiment table; assembling a plano-concave lens, a front lens and an optical coherence tomography (OCT) instrument; adjusting the three-dimensional experiment table to ensure that the eyeballs of the mouse are positioned right ahead the front lens, and that a clear retina scanning eye fundus image appears on a display screen of the OCT instrument; selecting a high-definition one-line scanning mode to obtain a cross-sectional image of the total retina of the mouse, and measuring the thickness of each layer on the retina of the mouse; selecting a retinal volume mode, aligning the center of a cross scanning line with the optic disk of the mouse to measure the average thickness and volume of nine subareas of the retina of the mouse, and reconstructing the form of the retina of the mouse in a three-dimensional mode; and finally, selecting an optic disk scanning mode to acquire continuous thickness data of a nerve fiber layer of the retina. The method has the characteristics of high simplicity and feasibility, high repeatability, accurate result and zero external environment interference and is suitable for popularization and application.

The invention discloses a fan blade fatigue limit attenuation intelligent monitoring method based on image recognition. The method comprises the steps that S1, building a fan blade rapid microscopic analysis system; S2, shooting the surfaces of a new fan blade and an old fan blade according to a sweeping mode to obtain complete micrographs of different blades; S3, analyzing a micrograph, and extracting damage characteristics of scratches, cracks and pits on surfaces of leaves; S4, quantifying state parameters of blade surface damage ; S5, carrying out vibration fatigue tests on the new fan blades and the old blades with different service duration; S6, obtaining fatigue limit data of the blades; S7, realizing a method for establishing a response surface through training data based on an artificial intelligence algorithm of a small sample; and S8, establishing a fatigue limit recession intelligent prediction algorithm based on the blade surface state characteristics to obtain a corresponding relationship between the blade surface damage state parameters and the blade fatigue limit degradation degree. The invention can quickly predict the attenuation of the fatigue limit of the blades.