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4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions. It is isomeric with 2-hydroxybenzoic acid, known as salicylic acid, a precursor to aspirin, and with 3-hydroxybenzoic acid.
A method for synthesizing 3,5-dibromo-4-hydroxycinnamic acid
PendingCN122102949AOrganic compound preparationCarboxylic acid amides preparationChemical synthesisBenzoic acid
The application relates to the technical field of chemical synthesis, and discloses a synthesis method of 3,5-dibromo-4-hydroxybenzonitrile; the synthesis method of 3,5-dibromo-4-hydroxybenzonitrile comprises the following steps: mixing p-hydroxybenzoic acid and a brominating agent in solvent I to obtain a mixture, adding an acidic reagent, carrying out reaction I, and obtaining 3,5-dibromo-4-hydroxybenzoic acid; mixing 3,5-dibromo-4-hydroxybenzoic acid and a chloride in solvent II, carrying out reaction II, and obtaining a reaction liquid containing 3,5-dibromo-4-hydroxybenzoyl chloride; adding an alkaline reagent to the reaction liquid containing 3,5-dibromo-4-hydroxybenzoyl chloride, carrying out reaction III, and obtaining 3,5-dibromo-4-hydroxybenzamide; contacting 3,5-dibromo-4-hydroxybenzamide with a dehydrating agent in solvent III, carrying out reaction IV, and obtaining 3,5-dibromo-4-hydroxybenzonitrile; the raw material p-hydroxybenzoic acid used in the application is cheap and easy to obtain, the raw material cost is low, the safety is high, the environmental protection pressure is small, and the technology is self-controllable.
Owner:浙江禾本科技股份有限公司