The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with liver nourishing and protecting effects and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises a first component and a second component, wherein the first component comprises 10-12 parts of Hangzhou write peony roots, 8-10 parts of curcuma zedoaria, 8-10 parts of common burred rhizomes, 10-14 parts of human placenta, 8-10 parts of chicken's gizzard-membrane, 10-12 parts of danshen roots, 10-14 parts of licorice roots, 8-12 parts of glossy privet fruits, 8-12 parts of eclipta alba, 7-9 parts of hawthorn, 7-9 parts of semen cannabis, 9-13 parts of sweet wormwood herb, 10-12 parts of virgate wormwood herb, 6-10 parts of cape jasmine, 3-5 parts of gentian and 10-14 parts of glabrous greenbrier rhizomes. Pharmacology and properties of multiple raw materials are combined, the medicine has effects of clearing heat, removing toxins, relieving pain and removing stasis, inducing diuresis, removing dampness, protecting liver and reducing enzyme and has good treatment effects on hepatopathy such as fatty liver, liver cirrhosis and liver cancer.