The invention relates to a traditional Chinese medicine prescription for treating chronic renal failure. The traditional Chinese medicine prescription is characterized by being prepared from, by weight, Radix Sophorae Flavescentis, Herba Polygoni Avicularis, Herba Plantaginis, Herba Leonuri, Rhizoma Polygoni Cuspidati, Cortex Eucommiae, Radix Dipsaci, Cibotium Barometz, Radix Cyathulae, Fructus Mume, Fructus Corni, Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis , Radix Et Rhizoma Rhei, Tortoiseshell, Radix Aconiti Lateralis Preparata, Semen Plantaginis, Spica Prunellae, Radix Ginseng and Rhizoma Smilacis Glabrae for one dose. One course of treatment with the traditional Chinese medicine prescription is one month, users should take one dose every two days, and effective rate is over 90%. Patients in the incipient stage of uremia can recover after taking the medicine for 10-15 days, and for patients undergoing dialysis, dialysis can be reduced step by step till dialysis is no longer needed. For patients with late-stage uremia, dialysis can be reduced to prevent deterioration, the renal function is improved quickly, and the treatment period is longer.