The invention discloses a manufacturing method of a flexible temperature sensor, relates to the technical field of flexible sensors, and aims to solve the technical problems of relatively large hysteresis and incapability of achieving high performance generally caused by incapability of high-temperature annealing in a preparation process of an existing flexible temperature sensor. According to thetechnical scheme, the method comprises the following steps of cleaning a hard substrate, performing photoetching forming, depositing a sacrificial layer and a metal layer, removing photoresist, performing high-temperature annealing, manufacturing a flexible substrate, and etching the sacrificial layer. The flexible temperature sensor can be obtained; the preparation method is suitable for the flexible wearable material sensitive to the temperature; the prepared flexible temperature sensor has both flexibility and strength, and the metal temperature-sensitive resistor is firstly manufactured on the rigid substrate, so that high-temperature annealing is carried out, the hardness of the metal temperature-sensitive resistor is improved, the residual stress is reduced, the problem of large hysteresis of the flexible sensor is solved, the metal structure is more stable, the structure defects are eliminated, and the overall performance of the flexible temperature sensor is improved.