37results about How to "Long excitation wavelength" patented technology

The invention provides an organic luminous material and a preparation method thereof, and relates to an organic silicon polymer. Raw materials of the organic luminous material comprise metallic organic substance and polycarbosilane. The preparation method comprises the following steps of: putting polydimethylsiloxane into a reaction kettle, heating the polydimethylsiloxane under the protection ofargon, inflating the argon to the reaction kettle, adding n-hexane into the reaction kettle to dissolve the product after the temperature in the reaction kettle is naturally cooled to room temperature, filtering the product, removing the n-hexane in vacuum to obtain the polycarbosilane, soaking the ground polycarbosilane into ethanol, flushing the insoluble substances by using the ethanol and then drying the insoluble substances in vacuum; and pouring the polycarbosilane powder and the metallic organic substance powder into a three-necked bottle, heating the mixed powder to between 150 and 160 DEG C under the protective atmosphere of argon, preserving the heat for 1 to 1.5 hours, heating the mixed powder to between 260 and 270 DEG C, preserving the heat for 1 to 1.5 hours, dissolving the product by using the dry n-hexane after the reaction is finished and the product is cooled, filtering the product to remove the insoluble substances, and finally distilling the product with reduced pressure to obtain the powdery solid organic luminous material.

Provided are preparation and application of a mercury ion fluorescent probe compound based on rhodamine B. The invention relates to the mercury ion fluorescent probe compound and the preparation and the application thereof, wherein the mercury ion fluorescent probe compound has the structure represented by the formula I. The preparation method comprises the steps: carrying out a reaction of 2,2'-bipyridine with methyl lithium under the protection of nitrogen gas to obtain 6-methyl-2,2'-bipyridine, then oxidizing methyl by selenium dioxide to obtain 6-aldehyde-2,2'-bipyridine; and carrying out a reaction of 6-aldehyde-2,2'-bipyridine and rhodamine B hydrazide to obtain the final product probe molecule. The probe molecule has good selectivity and sensitivity to mercury ions, has no toxicity to cells, and not only can be used for detection of mercury ions in water bodies but also can be used for detection and imaging of mercury ions in cells.

The invention discloses near-infrared fluorescent powder. A chemical general formula of the near-infrared fluorescent powder is Mg(3-x)Ga2CrxGeO8, wherein x is greater than 0 and is smaller than or equal to 0.1. The invention also discloses a preparation method of the near-infrared fluorescent powder. The preparation method comprises the following steps: weighing oxide or carbonate containing elements of Mg, Ga, Cr and Ge according to molar proportions of all elements in the chemical general formula Mg(3-x)Ga2CrxGeO8 of the near-infrared fluorescent powder, mixing, and grinding, thus obtaininga mixture; heating the mixture to 1200 to 1300 DEG C, and roasting for 3 to 4 hours, thus obtaining a sintered body; cooling the sintered body to room temperature, and fully grinding, thus obtainingthe near-infrared fluorescent powder. Meanwhile, the invention discloses application of the near-infrared fluorescent powder. The near-infrared fluorescent powder provided by the invention has longerexcitation wavelength and cannot be easily absorbed by a living body, an emission spectrum is in wide spectrum emission, the wavelength covers 700 to 1200nm which can cover one part of a first windowand a second window of a body biological window, the luminous strength is high, the stability is high, the preparation technology of the near-infrared fluorescent powder is simple, operation and control are easy, the safety is high, the preparation time is short, and the near-infrared fluorescent powder is convenient for large-scale production as well as popularization and application.

The invention discloses a time resolution fluorescent immunochromatographic test strip for detecting butralin, and a preparation method and application thereof. The time resolution fluorescent immunochromatographic test strip comprises a bottom plate and further comprises a sample absorbent pad, a combination releasing pad, a nitrocellulose membrane and a water absorbent pad which are lapped and pasted on the bottom plate in sequence. A butralin monoclonal antibody labelled by fluorescent microspheres is embedded into the combination releasing pad, and a detecting area and a quality control area are fixed to the nitrocellulose membrane. A butralin antigen-carrier protein conjugate is sprayed in the detecting area, and an anti-sheep and anti-mouse antibody is sprayed in the quality controlarea. A butralin antigen is obtained in the mode of reacting of 4-chlorine-3,5-binitro phenylacetic acid with butyl amine. The invention further provides the preparation method of the test strip and amethod for detecting the butralin in samples through the test strip. The time resolution fluorescent immunochromatographic test strip and the detecting method provided by the invention have the advantages that operation is easy, sensitivity is high, the detecting speed is high, and the cost is low, and the butralin in the large-batch samples can be detected quaickly and monitored on site.

The invention discloses a time resolution fluorescent immunochromatographic test strip for detecting pendimethalin, and a preparation method and application thereof. The time resolution fluorescent immunochromatographic test strip comprises a bottom plate, a sample absorbent pad, a combination absorbent pad, a nitrocellulose membrane and a water absorbent pad. A pendimethalin monoclonal antibody labelled by fluorescent microspheres is embedded into the combination absorbent pad, and a detecting area and a quality control area are fixed to the nitrocellulose membrane. A pendimethalin hapten-carrier protein conjugate is sprayed in the detecting area, and an anti-sheep and anti-mouse antibody is sprayed in the quality control area. A pendimethalin hapten is obtained in the modes that N-(1-ethyl propyl ether)-3,4-methyl toluidine and 4-bromo-butyric acid ethyl ester react to generate hydrocarbylation N-(1-ethyl propyl ether)-3,4-methyl toluidine, then the hydrocarbylation N-(1-ethyl propylether)-3,4-methyl toluidine reacts with concentrated nitric acid to generate nitro hydrocarbonylation N-(1-ethyl propyl ether)-3,4-methyl toluidine, and then the nitro hydrocarbonylation N-(1-ethyl propyl ether)-3,4-methyl toluidine reacts with KOH. The time resolution fluorescent immunochromatographic test strip and a detecting method provided by the invention have the advantages that operationis easy, sensitivity is high, the detecting speed is high, and the cost is low.

The invention discloses a compound I, a preparation method thereof and application of the compound I as a fluorescent probe. The compound I has near-infrared excitation/emission, the excitation wavelength ranges from 500 nm to 750 nm; and the compound is excited at a maximum absorption wavelength of 670 nm, and the emission wavelength is 700 to 810 nm. In addition, the compound I has an ultra-highsensitivity response to the PGP-1 enzyme. The detection limit for the PGP-1 enzyme at lambda ex/em=670/700 nm is 0.18 ng/mL. The compound I is used as a fluorescent probe to realize PGP-1 in vivo detection and fluorescence imaging for the first time. In vitro, cell and in vivo PGP-1 detection and fluorescence imaging can be realized, and all cells and tissues with inflammatory response and canceration can be assayed and imaged.

The invention belongs to the technical field of medical materials, and discloses a method for activating an anti-tumor compound through biological orthogonal photocatalytic oxidative dehydrogenation, a composition and application. The method comprises the following step: carrying out dehydrogenation reaction on dihydrobenzophenanthridine alkaloid under the conditions of illumination and oxygen and under the action of a photocatalyst to obtain the benzophenanthridine alkaloid. The composition is prepared from the dihydrobenzophenanthridine alkaloid and a photocatalyst. The invention also discloses application of the composition in preparation of a cell nucleus targeted light-activated imaging agent and/or a light-activated anti-tumor product. The oxidative dehydrogenation method is simple and efficient; the dihydrobenzophenanthridine alkaloid and the photocatalyst are high in light activation efficiency under the aerobic condition; the fluorescent probe is used in cells, is illuminated under the oxygen condition, can realize nucleus-targeted specific light-activated fluorescence imaging in living cells, and has the advantages of high light activation efficiency, low cytotoxicity and the like. Through illumination control, the composition disclosed by the invention has a relatively good anti-tumor effect.

The invention discloses a time resolution fluorescent immunochromatographic test strip for detecting metalaxyl, and a preparation method and application thereof. The time resolution fluorescent immunochromatographic test strip comprises a bottom plate and further comprises a sample absorbent pad, a combination releasing pad, a nitrocellulose membrane and a water absorbent pad which are lapped andpasted on the bottom plate in sequence. A metalaxyl monoclonal antibody labelled by fluorescent microspheres is embedded into the combination releasing pad, and a detecting area and a quality controlarea are fixed to the nitrocellulose membrane. A metalaxyl hapten-carrier protein conjugate is sprayed in the detecting area, an anti-sheep and anti-mouse antibody is sprayed in the quality control area, and a metalaxyl hapten is obtained in the modes that N-(2,6-dimethyl phenyl) alanine methyl ester reacts with (4-nitrophenoxy) acetylchloride to generate nitrobenzene metalaxyl, and then the nitrobenzene metalaxyl is subjected to zinc powder reduction. The time resolution fluorescent immunochromatographic test strip and a detecting method provided by the invention have the advantages that operation is easy, sensitivity is high, the detecting speed is high, and the cost is low, and the metalaxyl in large-batch samples can be detected quickly and monitored on site.

The invention discloses glycosyl beta-elemene derivatives having general formulae I, II and III. Researches indicate that the glycosyl beta-elemene derivatives have good biological water solubility and good anti-cancer activities, can be applied to malignant tumor treatment as an anti-cancer medicine for realizing real-time tumor monitoring and treatment, and have important scientific meaning to researches and application of beta-elemene in the field of medicine. Furthermore, the invention provides a method for preparing the corresponding compounds. The method applies a click chemical reaction technology, and is simple and scientific in synthesis.

The invention provides a composite resin aerogel, which is obtained by compounding an organic resin prepared from glycidyl methacrylate, divinyl benzene and ethylene glycol dimethacrylate with activated cellulose, then modifying with 3-alpha-furyl acrylic acid, and carrying out circulating freeze drying; or compounding the activated cellulose with organic resin, modifying with 3-alpha-furyl acrylic acid, loading a photocatalyst, and carrying out circulating freeze drying to obtain the product. The invention further provides a specific preparation method of the composite resin aerogel and an application method of the composite resin aerogel in sewage treatment, the process is simple, the effect is excellent, the aerogel is wrapped in the stainless steel grids, so that the contact area between the aerogel and sewage is large enough, the integrity of the aerogel is protected, and the aerogel can be repeatedly used; the composite resin aerogel is high in porosity, large in specific surface area, excellent in shape recovery performance, excellent in heavy metal ion adsorption performance, capable of being resolved and regenerated, capable of being recycled for multiple times and good in application potential.

The invention discloses a time-resolved fluorescence immunochromatographic test strip for detecting quinclorac, and a preparation method and an application thereof. The test strip comprises a bottom plate, and a sample absorption pad, a conjugate release pad, a nitrocellulose membrane and a water absorption pad which are sequentially lapped and pasted on the bottom plate; the conjugate release padis buried with a fluorescent microsphere-labeled quinclorac monoclonal antibody; a detection area and a quality control area are fixed on the nitrocellulose membrane; the detection area is coated with a quinclorac hapten-carrier protein conjugate; the quality control area is sprayed with a goat anti-mouse anti-antibody, wherein the quinclorac hapten obtained by the steps of enabling quinclorac tobe reacted with (1, 3-dioxanylethyl) magnesium bromide to generate propylal quinclorac, and then reacting with trifluoroacetic acid. The test strip and the detection method provided by the inventionhave the advantages of simplicity in operation, high sensitivity, high detection speed, low cost and capability of realizing rapid detection and on-site monitoring of quinclorac in a large quantity ofsamples.