The invention discloses a cold-rolled low-temperature acid dew point corrosion resistant steel and a manufacturing method thereof. The cold-rolled low-temperature acid dew point corrosion resistant steel comprises the following chemical components of, in percentage by mass, 0.04% to 0.12% of C, 0.25% to 0.35% of Si, 0.35% to 0.65% of Mn, less than or equal to 0.035% of P, 0.005% to 0.020% of S, 0.25% to 0.40% of Cu, 0.7% to 1.2% of Cr, 0.03% to 0.10% of Mo, 0.06% to 0.12% of Sb and the balance Fe and inevitable impurity elements. Meanwhile, the element content is controlled to meet the conditions that CR is larger than or equal to 0.25 and smaller than or equal to 0.5, CR = 0.5 w (Cu) + w (Sb) + 2w (Mo), and 10w (C)-CR is smaller than or equal to 0.8. A cold-rolled steel strip with excellent low-temperature sulfuric acid and hydrochloric acid mixed acid dew point corrosion resistance is prepared through continuous casting, hot rolling, cold rolling, continuous annealing and leveling, the yield strength is larger than or equal to 260 MPa, the tensile strength is larger than or equal to 400 MPa, the elongation is larger than or equal to 30%, and the cold-rolled steel strip is suitable for low-temperature flue gas treatment, waste heat recovery and other systems for thermal power, petrifaction, metallurgy, waste incineration and the like.