The invention relates to gargle with the drinking safety, comprising the following components by weight percent: 0.1-0.5 percent of tea polyphenols, 0.05-0.3 percent of magnolol, 0.05-0.3 percent of paeonol, 0.01-0.1 percent of phytic acid dodecasodium salt, 0.5-3 percent of glycyrrhizic acid, 1-5 percent of ethanol, 0.05-0.5 percent of mentha haplocalyx, 0.001-0.01 percent of essence, 0.05-0.2 percent of propylgallate, 0.01-0.1 percent of sodium cyclamate, 0.05-0.5 percent of macromolecule suspending agent, 0.3-2 percent of surface active agent and the balance of water. A preparation method of the gargle comprises the following steps of: adding tea polyphenols, magnolol, paeonol, propylgallate, mentha haplocalyx and essence into the ethanol according to the content and components, stirring for dissolving to obtain solution A; adding the phytic acid dodecasodium salt, glycyrrhizic acid, sodium cyclamate, macromolecule suspending agent and surface active agent into water, stirring for dissolving to obtain solution B; slowly adding the solution A into the solution B while stirring, and evenly stirring the mixture solution to obtain the gargle. The gargle has clear appearance, is slightly sweet in the mouth feel and ensures fresh breath after use.