The invention relates to a large-airspace high-dynamic navigation guidance and control integrated system and method. The system comprises an optical fiber inertia measurement unit, a multimode GNSS satellite receiver, a dual-core embedded flight control computer, a high-overload-resistant miniature black box, a combiner, a dual-path satellite antenna, a secondary power supply conversion module, abase and a shell. A navigation guidance and control program is run in the dual-core embedded flight control computer, the navigation program adopts a robust Kalman filtering algorithm to adjust Kalmanoptimal gain and posterior estimation error covariance on line, and the guidance and control program adopts a scheme attack angle on-line planning and self-adaptive control parameter design method. The system has the advantages of low cost, high integration level, small volume, high overload resistance, simplicity, economy, reliability and the like.