2 results about "Chloroquinocin" patented technology

This invention belongs to the pharmaceutical field, specifically relating to the synthesis of pharmaceutical intermediate compounds. Specifically, it relates to a method for preparing montelukast sodium using (E)-1-[3-(2-(7-chloroquinoline-2-yl)vinyl)phenyl]prop-2-en-1-ol and 2-(2-iodophenyl)prop-2-yl acetate as raw materials. This method not only has good impurity removal effects but also high product yield and purity. Furthermore, it does not require stringent synthesis conditions, making it suitable for large-scale industrial production.

This invention discloses a continuous flow synthesis method for olutanib, belonging to the field of pharmaceutical synthesis technology. The method involves mixing a solution of 2-cyano-5-fluoropyridine with an acidic solution of hydrogen peroxide and reacting the mixture in a first continuous flow reactor at 70-90°C to obtain intermediate 3; mixing a solution of 3 with an acid anhydride and reacting the mixture in a second continuous flow reactor at 90-100°C to obtain intermediate 4; pumping a solution of 4 and a methylating agent into a third continuous flow packed bed reactor and reacting the solution at 20-25°C to obtain intermediate 5; and then reacting intermediate 5 with (… S A solution of 3-(1-aminoethyl)-6-chloroquinoline-2(1H)-one was pumped into a fourth continuous flow packed bed reactor and reacted at 90-95°C. The resulting product was then purified to obtain olutanib. The total residence time of this method is only 118 minutes, eliminating the need for column chromatography purification. The process is continuous, safe, and controllable, with high production efficiency and ease of scale-up.